摘要:

Abstract:Erythema nodosum (EN) seems to occur in children more rarely than in adults. It still remains the most frequent acute panniculitis, for which the diagnosis is almost always clinical. In a retrospective study of 27 pediatric patients, we have attempted to clarify the clinical spectrum and prognosis of this disease and discuss the differential diagnosis of nodular eruptions on the lower limbs of children. In almost half the patients of our series, the cause of EN remained undetermined. Streptococ‐cal infections (usually of the pharynx) were the most common cause of EN in children (22% of patients in our series), followed by Yersinia infection in about 15% of patients. Tuberculosis, an important cause in the past, was never found, but must always be excluded. A benign course was noted in all patients. Erythema nodosum is easily recognized clinically, but other subcutaneous lesions, especially nodular vasculitis and Schönlein‐Henoch purpura, have to be excluded by pathologic study, in cases of atypical presentation or long dura

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00722.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:We present nine infants (3 to 10 months of age) with numerous small, papular, papular‐lichenoid, and papulo‐pustular lesions predominantly on the upper and lower limbs associated with local (axillary) lymphadenopathy which appeared after BCG vaccination. Histopathology of the lesions showed small tuberculoid granulomas mainly in the papillary dermis. The presence of BCG bacillus was demonstrated in five out of seven samples from the lymph nodes after culture and in one skin biopsy specimen. All cases, whether treated or not, evolved to complete resolution of the skin lesions. We believe that this peculiar association results from hematogenous spread of the bacillus, which regresses after an adequate immune system react

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00723.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Very little has been published about tegumentary leishmani‐asis in children and there are many controversies about this disorder in the literature. Therefore, we discuss the pathogenesis, clinical aspects, means to diagnosis, and treatment of this endemic diseas

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00724.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Mechanical properties of skin were evaluated in vivo in 17 children suffering from Ehlers‐Danlos syndrome (EDS) types I, II, and III. These were compared with normal values from 63 healthy children. Non‐invasive measurements were performed under suction of 500 mbar using a Cutometer equipped with a 4‐mm probe. Prominent increases in skin extensibility and elasticity were the most distinctive and diagnostic features of all three EDS types. Differences in the average values of biome‐chanical variables were present among the three types. Patients with EDS‐I were the most affected, whereas those with EDS‐III had virtually normal skin. However, interindividual differences in the severity of rheo‐logical alterations were found within each type, illustrating a continuum in the variation of mechanical properties of EDS skin rather than yielding step differences am

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00725.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Malignant rhabdoid tumor is a rare and highly aggressive malignancy of unknown etiology. We report a primary cutaneous rhabdoid tumor on the upper back of a newborn. It was initially diagnosed as a hemangioma clinically, and that diagnosis was supported by radiologic studies, including magnetic resonance imaging. However, detailed investigation with light microscopy, immunohistochemistry, and electron microscopy enabled us to make a diagnosis of rhabdoid tumor. This is the seventh reported case of rhabdoid tumor with primary cutaneous involvement.

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00726.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:We report an infant born with a cutaneous nodular eruption and neutropenia. Skin biopsy specimens revealed an immature dermal infiltrate suggestive of leukemia cutis, but repeated peripheral blood and bone marrow examinations failed to demonstrate malignant cells. The eruption resolved spontaneously. At the age of 3 months, a second occurrence of maculopapular skin lesions led to discovery of an acute monoblastic leukemia with (9;11)(p21–22;q23) translocation. Congenital acute leukemia is a rare disease associated with skin infiltration in 25% to 30% of patients. Usually the diagnosis is easily made by peripheral blood examination and/or bone marrow aspirate. However, skin involvement may precede acute leukemia by several weeks. Although very rare, this event must be kept in min

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00727.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:A 27‐year‐old woman and a 13‐year‐old girl diagnosed with juvenile dermatomyositis in childhood developed clinical findings of partial lipodystrophy 10 years after diagnosis. Exhaustive clinical and laboratory examinations showed an association with other abnormalities: hy‐pertrichosis, steatohepatitis, and an abnormal insulin response to the glucose loading test in the first patient. Hypertrichosis, steatohepatitis, insulin‐resistant diabetes mellitus, and acanthosis nigricans were observed in the second patient. Renal function was normal in both patients. Although a localized form of lipodystrophy has been reported associated with connective tissue disease (connective tissue lipoatrophy), the partial form has been infrequently described in association with juvenile derm

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00728.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Chronic meningococcemia is a rare form of meningococcal infection. Most reported cases occur in adults. Only about 10% of reported patients are under 18 years of age. We herein report chronic meningococcemia in a 17‐month‐old immunocompetent child and review the literature. Our patient had a 4‐month history of several episodes of intermittent fever accompanied by widespread erythematous and purpuric, crusted papules and pustules with necrotic centers. Blood cultures were positive for group CNeisseria meningitidis. Histopathology of a skin biopsy specimen revealed leukocytoclastic vasculitis. Because the disease is uncommon and can be confused with other conditions including other infectious processes, vasculitis, and collagen vascular diseases, it is important to have a high degree of suspicion for chronic meningococcemia. This will help avoid a delayed diagnosis and/or inappropriate treatment. The positive blood culture remains the diagnostic sine qua non. Treatment with ceftriaxone was rapidly successful in our pa

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00729.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Trichophyton rubrum infection on the face of a 3‐day‐old neonate is reported because of its rar

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00730.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Trichostasis spinulosa is a disorder of the pilosebaceous follicles that may simulate acne open comedones. It is a commonly reported cosmetic annoyance in adults but not children. A review of the literature and a case of trichostasis spinulosa in a 13‐year‐old black girl with a history of onset at 18 months of age are presen

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb00731.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY