摘要:

Abstract:Although xanthogranulomas are frequently encountered by pediatricians and dermatologists, data on the course of this tumor are restricted to several series with limited follow‐up. We report on our experience with 64 patients whom we were able to identify from the surgical files. Our data support the currently held view that xanthogranulomas are generally benign, self‐limited lesions. They may persist or continue to erupt for years, however, particularly in individuals who develop the first lesion after age 20 ye

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00909.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Pemphigoid is an autolmmune blistering disease that is rare in childhood. A review of the English, German, and French literature published prior to 1989 revealed 31 cases of juvenile bullous pemphigoid and 12 of other forms (10 cases of juvenile cicatricial and 2 of juvenile localized bullous pemphigoid). Childhood pemphigoid, although less frequent, seems no different than its adult counterpart. While oral lesions are more common in the juvenile bullous form, there is no association with malignancy, which is a controversial and presumably incorrectly assumed association in the adult disease. The prognosis for children is good in most cases, and the disease is self‐limiting.The mainstay of therapy has been oral corticosteroids, but dapsone also often produces a good response. A relatively new approach is to give a combination of erythromycin and niacinamide with dapsone for a steroid‐sparing effect. In some patients the response to erythromycin plus niacinamide alone has been satisfactory; however, controlled therapeutic trials are lacking.It has been stated that high doses of steroids and immunosuppressive drugs are indicated for the cicatricial, as opposed to juvenile, bullous pemphigoid. From this review of the few cases of childhood cicatricial disease, it seems that the therapeutic approach might be the same for both fo

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00910.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Sexually transmitted diseases (STDs) represent a significant health problem for adolescents in the United States. As a result, clinicians from a number of discplines, among them pediatrics and dermatology, may be called on to evaluate teenage patients with these infections. Traditionally, the diagnosis of many STDs has relied on isolation of the causative organisms in culture. While such procedures typically offer optimal diagnostic accuracy, they are often time consuming and expensive, and may not be widely available. In an attempt to remedy this, cultureindependent techniques have been developed to permit more rapid and economical diagnosis of these important pathogens. The strengths and limitations of these methods must be understood, however, for the tests to be used effectively.

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00911.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Pigmented tumors resembling cutaneous melanoma were first reported in Sinclair miniature swine in 1967. Since that time, carefully planned breeding has established that this is an inherited malignancy the natural history of which mimics human cutaneous melanoma in a number of ways. Because of these characteristics, miniature swine melanoma appears to be an effective model with which to investigate the mechanisms influencing initiation, growth, and progression of human melanoma. This investigation characterized histologically the cutaneous melanoma in miniature swine and compared the findings with human neoplasm. Primary cutarteous melanoma in swine has been reclassified and standardized according to the classifications currently in vogue in human melanoma. Our results suggest that the condition in minlature swine is histologically similar to that in humans. These observations will provide a basis for interpretation of the results derived in the biologic studies performed in this model.

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00912.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:A 6‐month‐old girl had blisters on her volar index finger and palm. Bacterial culture grew group B streptococcl. Group B streptococci (in addition to group A streptococci) can be a cause of blistering dactyli

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00913.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:A 34‐month‐old Haltian girl had a six‐month history of asymptomatic vulvar papules. Histologic features and DNA probe studies were diagnostic of bowenold papulosis. Resolution of the lesions was enhanced by cryotherapy. This is the third reported patient with prepubertal bowenold papulosis. Sexual abuse should be suspected, but not assumed, in pediatric patients with this condition. Our patient had no evidence of sexual abuse. Bowenold papulosis has been associated with cervical intraepithellal neoplasia and rarely with squamous cell carcinoma. Close gynecologic fellow‐up is reco

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00914.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Congenital leukemia is a rare disease that can become manifest soon after birth. Cutaneous involvement consists of red, brown, or purple papules and nodules, and confluent areas of purpura. The diagnosis is established by the presence of leukemic cells in biopsy specimens of bone marrow and involved skin, and by immunocytochemical characterization of these cells. We report a case of congenital monocytic leukemia with a normal karyotype, whose disease underwent temporary spontaneous regression.

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00915.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:The Sjdgren‐Larsson syndrome is defined as the association of ichthyosis, spastic diplegia or tetrapiegia, and mental retardation. Although most cases described have come from the Swedish county of Vasterbotten, isolated reports from the United States and elsewhere do exist Numerous neurologic abnormalities have been reported with this syndrome, including speech defects, seizures, and pyramidal tract disorders. Abnormal ophthaimologic findings are not rare. Prevlous studies with computerized tomographic (CT) scans have revealed no abnormalities of cranial anatomy. We report a 6‐year‐old boy with Sidgren‐Larsson syndrome who had a Dandy‐Walker malformation as demonstrated by diagnostic imaging by CT and magnetic resonance imaging scans. This case illustrates that developmental defects of the central nervous system can also occur in association with Sjdgren‐Larss

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00916.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:The epidermal nevus syndrome is a disorder characterized by epidermal nevi and associated neurologic, skeletal, and other abnormalities. We cared for a 3‐month‐old male with multiple epidermal nevi and severe central nervous system involvem

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00917.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:We present a 4‐year‐old girl with polklloderma, radiai aplasia, short stature, facial dysmorphism, and sparse hair. We believe these findings to be consistent with a diagnosis of Rothmund‐Thomson syn

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1989.tb00918.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY