摘要:

Abstract:We report a Japanese patient with congenital hypomelanosis with a segmental pattern on the lett abdomen, whorl‐like pattern on the back; mosaic pattern on the chest, right abdomen, and proximal extremitiea; and with yellow hair on a portion of the scalp. Chemical analysis of the yallow hair revealed decreased eumetanin content, whereas the pheometanin content was norma

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00363.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:To determine whether aeroaltergens could induce eczematous lesions, 30 patients with atopic dermatitis were studied in comparison with 30 patients with respiratory atopy without atopic dermatitis. All patients were between 2 end 14 years of age. Patch testing with five aeroallergens—housedust, mite, cockroach, mold mix, and grass mixwas done on skin that was stripped by 10 applications of adhesive tape. Intradermal tests with the same antigens were done on the forearm. In 27 (90%) children with staple dermatitis, patch testing with aeroallergens Induced eczematous lesions at one or more sites. Mite, cockroach, house dust, mold mix, and grass mix caused reactions In 21 (70%), 21 (70%), 19 (63%), 15 (50%), and 13 (43%) patients, respectively. Three patients had a dermatitis flare at the antecubital and popliteal fossae during testing. Only three (10%) atopic children without atopic dermatitis had eczematous lesions, which was significantly different from children with atopic dermatitis (P<10−5). Intradermai skin tests in both groups were not significantly different This study supports previous reports that aeroallergens play an Important role in causing eczamatous skin lesi

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00364.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:Four cases of harlequin fetus of various estimated gastational ages (16, 20, 21, 24 weeks) were examined by light and electron microscopy. When the epidermis was keratinized the following features were commonly found: hyperkeratosis with or without granular cells; dilated hair follicles with plugged keratin; a large number of dense or particle‐cored granules In the upper malpighlan layer; absence of cementsomes (lamellar bodies); large vacuotes with peripherally located laminations; large mitochondria with vesicular or membranous cristae; and early formation of the marginal band in keratinocytea and abnormal formotion of the same in luminal cells of the acrosyringlum. A 16‐week specimen had no sign of karatinization, which made It difficult to detect these abnormalities; however, it did have large mitochondria in the keratlnocytes. The mucous membrane of the lip was thickened but not keratini

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00365.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:Piebaldism was associated with neurofibromatosis 1 (NF‐1) in two patients, an association not previously reported. Dopa staining (tyroslnase) and electron microscopy were performed: no melanocytes or melanosomes were found in hypomelanotic skin of patient 2 and in the white forelock skin of patient 1; in patient 2, normal melanocytes and melanosomes were present in the white forelock epidermis but absent from the cortex, cuticles, and inner root sheath of the while forelock hair. Because these structures receive melanosornes from melanocytes in the hair bulb, it was assumed that there were no melanocytes in the hair matrix. Melanocytes and melanosornes were normsl by ultrastructural criteria and in terms of their distribution in a normally pig men ted macule within a hypomelanotic patch of patient 2. These and earlier report findings led to three conclusions: subtypes of piebaldism exist, Including our patients showing a combination of piebaldism and NF‐1; the most commonly reported subtype has no melanocytes in the white forelock and hypomelanotic skin, although microscopic islands of melanocytes may exist within hypomelanotic skin; and the infrastructure of white forelock skin and hair of patient 2 is consistent with a mouse model of piebaldism, in which the hair follicle has no active melanocytes, but the interfollicular epidermis is normally melani

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00366.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:A 4‐year‐old mentally retarded girl had congenltel depignentationft of ventrolateral parts of the chest, abdomen, and legs. She also showed dysmorphic features of the head, thorax, and extremities, a pig‐mented ring in both irises, and a hemla of the left obliquus muscle. Cytogenetic Investigations reveated deletion of chromosome 4 for the long arm segment q12‐q21. The typical depigmentations, reported in tour other patients with a similar chromosomal deletion, correspond with those in the autosomal dominant piebald trait Mutations in the Kit protooneogene (mapped to the chromosome (4q11–4q12 region) have been found in patients affected with this dominant disorder. Piebaldism in children with developmental delay and dysmorphic features should alert the physician to the possibility of a deletion of the long arm of chr

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00367.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:Two sporadic cases of Heck disease in Polish girts were associated with human papillomavirus 13. No other children and nobody from their surroundings had similar lesions. The course of the disease was chronic in both patients. The lesions regressed spontaneously in one girl within several years after some of the papules were excised. The second girl's warts persist after eight years.

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00368.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:Two sisters of Mexican ancestry had focal epithelial hyperplasb (FEH). The lesions on the oral mucosa of the older child were initially misinterpreted as representing sexual abuse. Microscopic evaluation of a hematoxylin and eosln‐stained section from a lower lip papule demonstrated the histologic features of FEH. Although human papllloma‐virus (HPV) type 13 and HPV32 have been most consistently present In FEH lesions, types 6,11,13, and 32 were not detected In the paraffin‐embedded tissue specimen of our patient using an in situ hybridization technique. The lesions persisted or recurred during management using destructive modalities; subsequently, they comptetety resolved spontane

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00369.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:A 13‐year‐old girl had a six‐year history of infiltrated erythematous plaques on the face, alopecia of the eyebrows, diffuse alopecia at the scalp, and absence of body hair. Histologicaily, the lesions on the face and body corresponded to trichoepitheliomas. The lesions on the face clinically simulated lepromatous leprosy. This case probably represents an entity not previously desc

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00370.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:A 12‐year‐old girl with ulcerative colitis (UC) treated by colectomy with rectal stump preservation, salazopyrin, and systemic steroids developed persistent mouth ulcers, cutaneous target like lesions, papulopustules, and builae. The clinical, histologic, and immunopatriologic features were typical of chronic bullous disease of childhood (CBDC). Although resistant to combined Immunosuppressive therapy with low‐dose prednisolone, cyclosporin, and thalldomide, striking remission of the mucocutaneous symptoms resulted with surgital resection of the diseased rectal stump. An etiologic association between CBDC and UC Is postu

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00371.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Abstract:Perianal dermatitis has been reported to be caused by group A ß‐hemolytic Streptococcus. We present a case caused by Staphylococcus aureus. A clinical clue pointing to this organism was the presence of satellite pustules, identifying the pathogen in perianal dermatitis is therapeutically Important, as oral penicillin VK will not be effective If 5. aureus is the true cause. Other streptococcal and staphylococcal cutaneous infections may exhibit overlapping clinical features, including scarlet fever, Impetigo, toxic shock syndrome, and cellulit

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1993.tb00372.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY