摘要:

SUMMARY—The clinical course in 4 patients with renal carcinoma stages II, Ill or IV subjected to periods of extracorporeal immunoadsorption is reported. By this technique we have previously demonstrated that it is possible to isolate and remove circulating tumour associated antigens from the blood stream. The removal of these antigens should, according to present‐day concepts, make it possible to control “antigenic inhibition” and/or “blocking”, thus facilitating the immune mediated destruction of residual tumour cells in advanced disease. The clinical course in these patients, however, did not differ from the expected clinical course in other such patients. The failure of extracorporeal immunoadsorption to alter the natural course of the disease may be due either to too large a tumour burden or to the possibility that spontaneous tumours during evolution and progression become independent of immune r

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03142.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—Twenty‐three human cadaver kidneys were studied during hypothermic pulsatile perfusion prior to transplantation. The accumulation of laevo‐lactate and lactate dehydrogenase, alterations in pH and perfusion flow rate were measured and compared with organ function following transplantation. No parameter measured was found to be an accurate index of potential fun

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03143.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—A technique for dissolving a. renal stone complicating an ileal conduit is described. Free ureteric reflux was present, which allowed retrograde irrigation of the stone by infusion of hemiacidrin solution into the ileal conduit. With careful attention to urine infection and the pressure within the system, this technique might be applicable to other patients in whom free ureteric reflux is present and pyelolithotomy, percutaneous nephrostomy or the passage of ureteric catheters is difficul

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03144.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—In 2 separate series of dogs a segment of ureter was isolated from both bladder and kidney and leftin situwith an intact blood supply. Tense cysts formed in these sequestered segments regardless of whether the ends were occluded or the segments were split longitudinally and left open. The formation of these cysts can be prevented by the removal of the urothelium. The cyst contents were found consistently to have a sodium concentration below that of the simultaneously obtained serum concentration and urea concentration higher than the simultaneously obtained serum urea. Osmolalities and protein levels within the cysts were virtually identical to the serum level

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03145.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—We have used a simple method of ureteroneocystostomy in renal transplant patients. This entails a no‐tunnel “drop‐in” with a long free segment protruding into the bladder lumen. The incidence of vesicoureteric reflux was investigated in 81 transplant patients who had a follow‐up period ranging from 4 months to 1 5 years (mean 3.7 years); 29 of these patients had recurrent urinary tract infections. Micturating cystography demonstrated reflux in 6 patients (7.4%). In these 6 patients the presence of reflux had no deleterious effect on renal function and the infections were easily controlled with long‐term antibiotics. In the 52 patients without urinary infection no reflux was demonstrated.The conclusions based on this study indicate that1in the absence of recurrent infection there are no indications for micturating cystography and2this method of ureteroneocystostomy is expedient and has a low incide

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03146.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—Seven cases of colonic tumours occurring at the ureterocolic anastomosis (UCA) in patients diverted for benign disease are presented and comparisons made with existing literature.There appears to be a definite increase in the incidence of colonic malignancy in patients with this diversion. A theory of carcinogenesis involving bacterial activation of endogenously formed N‐nitrosamine is suggested. Preliminary results of rectal urine analysis support this theory in that high concentrations of N‐nitrosamine have been found and mutagens demonst

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03147.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—A new surgical technique for primary reconstruction of bladder exstrophy is described. Human cranial dura mater is used as an alloplastic free graft to replace the missing anterior bladder wall. The technique has been successfully applied to 8 patients and the early achievement of good bladder capacity seems to improve urinary continenc

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03148.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—The treatment of a 29‐year‐old woman with intermittent urinary retention using biofeedback is described and discussed in the context of the pathophysiology of reflux urethral instability and related disorders of micturition. During attempts to train the patient to raise the pitch of an auditory biofeedback signal, which varied directly with intrinsic bladder pressure, evidence appeared for the involvement of sensory neuronal pathways in the disorder. This and other evidence are incorporated within an explanatory hypot

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03149.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—The effect of 4 weeks' treatment with emepronium bromide in 20 incontinent female patients with detrusor hyperreflexia was compared to the effect in 20 patients who did not have uninhibited detrusor contractions during filling cystometry but who were unable to suppress a voluntarily induced detrusor contraction.In both groups, 65% benefited from the drug and no statistically significant differences were seen in the decrease in frequency of voiding and incontinence episodes during treatment. There were no differences between the groups for age, type and degree of urinary incontinence, and radiological findings of bladder suspension defects.In these patients it is important to perform cystometry, including detrusor reflex activation procedures and the testing of their ability to suppress a voluntarily induced detrusor contractio

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03150.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY—Histological and chemical studies were carried out on the elastin and collagen content of the normal and the obstructed urinary bladder wall. The observations were made on 3 different age groups: (1) 3‐month‐old children with vesical outlet obstruction, (2) children aged between 4 and 8 years with partial vesical obstruction, and (3) adults with a chronically obstructed bladder.An increase in elastic tissue was shown only in the newborn and in the adults. The collagen did not vary in any of the cases studied. The elastin showed an increase in polar amino acids in the pathological organs compared with the normal. A similar increase in elastin was observed in normal individuals as a result of the ageing pr

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1981.tb03151.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY