ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10095.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10096.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYOxymetholone 100 mg. per day was given to 60 patients in chronic renal failure, 55 of whom were receiving regular hæmodialysis. Thirty‐nine of the dialysed patients completed a cross‐over double blind trial of oxymetholone, 30 of them taking the active drug for 3 months; there was no significant change in hæmoglobin or hæmatocrit. No significant change occurred in liver function tests and the only side effect that appeared more than occasionally was a characteristic fattening of facial tissues which reverted to normal after withdrawal of the drug.One patient with polycystic disease treated by Giovannetti diet sustained a rise in hæmoglobin from 8·4 to 10·8 g./100 ml. while taking oxymetholone for 10 months.On present evidence oxymetholone in safe dosage has little or no role in treating the anæmia or renal failure, but trials of other anabolic steroids with less masculinising effect than testosterone shoul

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10097.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYAngiography of a human transplanted kidney showed arterio‐venous shunting (the “Oxford or Trueta phenomenon”). The presence of this phenomenon in a renal graft may be a further sign suggesting reje

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10098.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYTwo cases of apparently segmental pyelonephritis encountered at surgical exploration of the kidney are presented. It is postulated that this is a stage in the spectrum of acute inflammatory lesions of the kidney which falls between acute pyelonephritis on the one hand and renal abscess or carbuncle on the other. In clinical practice the diagnosis is infrequently made at this stage because the radiographic appearances indicative of a localised space‐occupying lesion are not necessarily present. Antibiotic treatment during this stage of the disease may be adequate. However, because of the difficulty in deciding whether an abscess is present or not, failure of the clinical and radiological response to treatment would indicate the necessity for surgical exploratio

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10099.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYA series of isometric studies were performed on rat ureters to investigate the effect of pre‐treatment with œstrogen and progesterone on the α‐and β‐adrenergic responses.The results indicate a facilitation or enrichment of the α‐adrenergic response by œstrogen, and a similar effect on the β‐response by progesterone.It is suggested that the hormonal component of the ureteric dilatation of pregnancy is the result of the effect of progesterone on the β‐ad

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10100.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYDiagnosis and treatment of ureteral metastasis from prostatic carcinoma is discussed via an illustrative case report.

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10101.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYEctopic ureterocele is a common condition in pædiatrics, which can, in general, be recognised from a standard intravenous urographic series. The full potential of radiological diagnosis is seldom exploited, however, and this paper gives examples of ways in which careful studies of micturating cystograms can give precise information about the nature and complications of the ureterocele, which are essential for rational planning of surgical treatment

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10102.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe results from our first 43 treatments suggest the following:High malignant tumours are more sensitive to pressure treatment than low malignant types (Table VII).The situation of the tumour is of importance in so far as tumours situated close to the passage of larger vessels through the bladder wall responded poorly (Table VIII).The duration of increased intravesical pressure at values corresponding to or exceeding the diastolic (and below the systolic) blood pressure to a large extent determine the treatment result (Tables IX and X).Thus we found partial necrosis in 1 patient only who, considering the above‐mentioned factors, was treated under optimal conditions, stressing the importance of taking these factors into account when deciding upon the duration of the procedure.Hydrostatic pressure treatment is a new method and the exact definition of its indications has not yet been finalised. Patients treated up till now fall into the following groups:Extensive papillomatosisresponding poorly to other treatment regimens. Recurrences, mostly isolated tumours, may occur 8–13 months after pressure treatment. These tumours are easily controlled by electrocoagulation treatment.Large isolated tumoursof malignancy grade II in patients not suited for more extensive surgical interventions.Highly malignant tumoursare most sensitive and this type of tumour represents in our opinion the most important indication. This is in particular true for tumours not infrequently seen close to the trigone or bladder neck. Total extirpation of the bladder and urinary diversion are in such cases the only alternative surgical treatment.Highly malignant, far advanced tumoursnot accessible for irradiation or surgery. The palliative improvement obtained in such cases is not without importance, considering that some of the patients lived for a further year after treatment not forgetting the influence of the procedure on pain, voiding need, hæmorrhage and urinary incontinence. In addition improved general well‐being of the patients is not infrequently seen.Hydrostatic pressure treatment may be combined with other therapeutic procedures such as irradiation. Irradiation after pressure treatment should however be delayed for 1–2 months in order not to disturb possible immunological processes.After technical failures of hydrostatic pressure treatment, the procedure may be repeated. Even following mucosal hernia, treatment may be repeated after approximately 1 week. The second treatment, however, should always be carried out by the balloon method.After muscle ruptures at least 2 months should elapse before re‐treatment.If the primary result is unsatisfactory the interval before re‐treatment may depend on the grade of malignancy of the tumour. If total necrosis of the tumour has not been achieved, low grade malignant tumours may be re‐treated already after 1 month as necrosis normally then is completed. In highly malignant tumours at least 2–3 months should elapse.We have no experience regarding pressure treatment of recurrent bladder cancer in previously irradiated patients. If such patients are to be treated, however, it should be remembered that the immunological response of irradiated patients may be decreased. This may have an unfavourable influence upon the result of pressure treatment.Pressure treatment after previous electrocoagulation presented no difficulties. The same is true for patients having undergone bladder surgery, due to other diseases.Finally, the balloon‐method is technically less difficult than the Foley catheter technique. It is therefore recommended that the balloon method should be used initially until experience in the application of the hydrostatic pressure treatme

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10103.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SUMMARYThe histopathological features of cystectomy specimens of carcinoma of bladder have been reviewed and related to the subsequent clinical course. The cases studied had also had some form of radiotherapy before cystectomy.Deep invasion, poor differentiation and high mitotic activity in the tumour, lymphatic vessel permeation and lymph node metastases were all associated with a high proportion of deaths from tumour in the first 3 and 5 years following operation, as were absence or patchy distribution of round‐cell infiltration around the invading tumour edge, particularly a poor plasma cell response. No relation was found between the clinical course and degree of pleomorphism of the tumour or fibrosis, vascular changes, lymphocyte, eosinophil or tissue mast‐cell‐infiltration in the tissues surrounding the tumour, or to lymph node histology apart from the presence or absence of actual tumour dep

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1972.tb10104.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY