ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10034.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10035.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARYOne hundred patients with advanced prostatic carcinoma have been treated by Yttrium90pituitary ablation. The results show that:1 Thirty‐nine patients experienced complete and sustained symptomatic relief; 32 showed a partial or temporary response; and 29 cases showed no response.2 The previous response to œestrogens or previous orchidectomy appear to have little influence on the subsequent result of implantation.3 A favourable result may be slightly more likely in patients aged less than 60, or in patients who have had the disease for more than

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10036.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARYTwenty‐three patients treated by Yttrium90ablation of the pituitary gland are presented. In 52 per cent of the patients there has been good symptomatic response to treatment and a further 22 per cent have had a partial response to treatment. It is a comparatively simple and safe method of treatment and is well worth while considering in the management of the late stages of carcinoma of the prostat

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10037.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARY1 B6‐deficient rats and calcium oxalate stone‐forming patients share several metabolic abnormalities.2 In our experiments, evidence for folic acid deficiency in the stone patients is strong, and some evidence exists in B6–deficient rats as well.3 Susceptibility to overload of the acetyl coenzyme A system is high in both.4 Sources of oxalic acid probably include aromatic amino acid derivatives with a 3 carbon side chain, whose metabolism is blocked by tyrosine, and whose dependence on the acetyl coenzyme A system is shown by the simultaneous drop in oxalate, hippurate, α‐ketoglutarate and citric acids. That hydroxy‐proline is a major source seems a probable explanation for changes in oxalate excretion with stress.5 Both B6–deficient rats and hyperoxaluric patients respond to tyrosine administration by a d

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10038.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARYExperiments have been carried out to test the hypothesis that renal damage caused by ischsemia is due to the intrarenal build‐up of ammonia.It has been shown that the ammonia concentration in dog kidneys after prolonged ischcemia is approximately 4 micromoles/gram of kidney.Renal function studies (creatinine clearance, TmPAH, osmolar clearance, renal plasma flow) have been carried out on 6 unilaterally nephrectomised dogs before, during and after the concentration of ammonia in renal tissue had been artificially raised by an infusion of ammonia into the renal artery.In one dog ammonia injections sufficient to raise the blood ammonia to 1,000 micrograms/100 ml. caused circulatory collapse and death. A second dog, with elevation of tissue ammonia to 12 micromoles per gram of kidney, showed a temporary reduction in renal function which returned to normal when the injection was discontinued. In the other animals, an ammonia infusion which raised tissue ammonia to 3.4–7.1 micromoles per gram had little effect on renal function.It seems unlikely that the ammonia produced by the ischemic kidney contributes significantly to ischsemic renal dam

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10039.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARY1 One hundred patients in a state of chronic renal failure have been studied, to determine the degree of renal impairment when infusion pyelography fails to be of diagnostic value, using the serum creatinine and blood urea concentration as an index of renal function.2 The critical level of the serum creatinine is 5.0 mg./100 ml., and the blood urea 130 mg./100 ml. Up to these levels the whole urinary tract from the calyces of the kidney to the bladder can usually be displayed, and a distinction made between the obstructed and the non‐obstructed kidney, a crucial problem. Above the critical levels no useful result can be expected, though in 2 patients with blood urea values greater than 250 mg./100 ml. there was sufficient contrast filling in the collective system to make a confident diagnosis.3 The critical levels of blood urea and creatinine are much higher (and hence greater renal damage) using drip infusion pyelography as compared with the standard i.v.p.4 In patients with severe renal disease the nephrogram may still afford information of diagnostic value when the pyelogram is absent, or when contrast filling of the collecting system is poor. Despite the low contrast concentration, it is often possible, with the use of tomography, to make important observations on renal size and exclude a treatable obstructive lesion of the urin

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10040.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARYThree cases of rare primary renal sarcoma have been reported and described (one case each of leiomyosarcoma, fibrosarcoma and nephroblastoma in an adult). The relevant literature has been reviewed and discussed. A total of 32 cases of leiomyosarcoma, 107 cases of fibrosarcoma and 126 cases of nephroblastoma in adults have been collected from the world literature, and analysed.

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10041.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10042.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SUMMARYThree cases of carcinoma complicating uretero‐colic anastomosis are described, and the findings in these and in a further 25 recorded in the literature are reviewed.The tumours may be of glandular type or originate in the urothelium. In most of the recorded cases the antecedent lesion was benign. Patients with uretero‐colic anastomoses need to be followed up regularly, and for many years, particular attention being paid to bowel symptoms or evidence of urinary obstruction. The prognosis is likely to be poor if the tumour that develops is of transitional or anaplastic t

ISSN:0007-1331    

DOI:10.1111/j.1464-410X.1971.tb10043.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY