摘要:

The invasiveness of laparoscopic varicocelectomy and‐ open retroperitoneal high ligation of the internal spermatic veins were compared and the surgical effects on fertility of these two procedures determined. 48 of 97 men diagnosed with varicocele testis underwent laparoscopic varicocelectomy, while the remaining 49 underwent open retroperitoneal high ligation of the internal spermatic vessels. Operating time, number of post‐operative days to walking, length of hospital stay and analgesic use were measured as peri‐operative indicators of invasiveness. In addition, seminal parameters were determined in order to evaluate the effects of these procedures on fertility. The operating time required for laparoscopic surgery was significantly longer than that for open surgery (96.6 vs 78.1 min., p = 0.0078). The patients in the laparoscopic surgery group began walking earlier post‐operatively than did those who underwent open high ligation (0.97 vs 1.42 days, p = 0.00037). Length of hospital stay for the laparoscopic patients was shorter than for the open surgery group (7.05 vs 9.55 days, p=0.00001). There were no statistical differences between the groups in terms of semen quality or improvement in the post‐operative rate of pregnancy of partners. These findings indicate that laparoscopic varicocelectomy is associated with a shorter period of convalescence than open high ligation of the internal spermati

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00011.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

It is known that diffusible trophic factors play an important role in both the normal and cancerous growth regulatory processes of hormone‐responsive cells such as are found in the prostate and mammary glands. Consequently, it is important to identify whether the production of such growth factors is affected by administration of therapeutic agents. We examined the effect of bestrabucil, a benzoate of an estradiol‐chlorambucil conjugate, on the production of growth factor(s) by Shionogi carcinoma 115 (SC‐115) cells, an androgen‐responsive cultured cancer cell line. We then investigated whether the inhibitory effect found was specific to bestrabucil, or if it was also produced by a mixture of the 2 compounds, estradiol and chlorambucil. Bioassay employing BALB/3T3 cells demonstrated the presence of two kinds of growth factor in the conditioned medium obtained by culturing SC‐115 cells in medium containing 10‐8M testosterone; these factors could be separated by heparin‐sepharose column chromatography using 0.5 M NaCI and 1.1 M NaCI. When the SC‐115 cells were cultured in medium containing bestrabucil, at a concentration of 10−5M, no growth factor activity was detected in the fraction eluted from the heparin‐sepharose column by 1.1 M NaCI. At bestrabucil concentrations of 105‐107M, concentration‐dependent inhibition of growth factor production by SC‐115 cells could be demonstrated by3H‐thymidine uptake assay. However, this inhibitory effect could not be demonstrated using only a mixture of estradiol and chlorambucil. The finding that bestrabucil specifically inhibits the production of growth factor(s) may help in the development of a new class of drugs which will be clinically useful in treatin

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00012.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Prostate‐specific antigen (PSA) is a kallikrein‐like serine protease that is secreted exclusively by the epithelial cells of all types of prostatic tissue, benign and malignant. Its serum concentration is raised in men with prostatic disease including cancer. We have evaluated its usefulness in the diagnosis of prostate cancer by measuring serum PSA concentrations in 260 men aged 50 years or over. All had abnormalities at digital rectal examination (DRE) involving suspected cancer, signs and symptoms of benign prostatic hyperplasia and equivocal findings on DRE, and miscellaneous other conditions, including hematospermia, chronic prostatitis and microscopic hematuria. Transrectal prostatic needle biopsies were performed in the men with abnormal findings on DRE or elevated serum PSA (above 4ng/ml). Serum PSA ranged from 4.0 to 9.9ng/ml in 14 (5%) of the 260 men. Four of the men in this group (31%) who underwent prostatic biopsy had prostate cancer. Serum PSA levels greater than or equal to 10.0 ng/ml were found in 8 (3%) of the 260 men. 5 of these 8 (63%) who underwent prostatic biopsy had cancer. If DRE alone had been used to screen the men having biopsies, 4 of the 10 cancers (40%) would have been missed. If PSA alone had been used to screen these men, only 1 of the 10 cancers would have been missed. Serum PSA measurement was more reliable than DRE for detecting prostate cancer. Since these two methods do not always detect the same malignant tumor, the combined use of DRE and PSA testing affords a more complete evaluation of the prostate gland for malignant involvem

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00013.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

We report our investigation of urinary incontinence in 51 male paraplegics with radical transurethral resection of the prostate. Pre‐operatively, 28 cases (55.9%) had moderate or severe incontinence, which persisted post‐operatively only in 21 cases (41.2%) and was less severe. Post‐operatively, bladder compliance was improved from 22.1 22.6 ml/cmH2O to 36.4 38.5 ml/cmH2O, and the maximum pressure of uninhibited detrusor contraction was reduced from 40.2 21.5 cmHzO to 18.3 19.0 cmH2O. These significant improvements are thought to contribute to the relief of urinary incontinence, regardless of the reduction in maximum urethral closure pre

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00014.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

This paper presents a case of right renal cell carcinoma with a false‐positive finding of tumor thrombus in the inferior vena cava. The intraluminal filling defect revealed by computed tomography appeared to be an artifact due to the inflow of non‐opacified blood into the inferior vena cava. The possibility of such an artifact should be borne in mind to avoid as far as possible any unnecessary diagnostic intervention and delay in instituting proper ther

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00015.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

A case of metastatic choriocarcinoma of the testis involving the retroperitoneum, lung, bone, and brain was successfully treated by surgery, chemotherapy and radiotherapy.

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00016.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

We report a case of a mullerian duct cyst associated with a 46, XYq‐ chromosome anomaly. Mullerian duct cyst is a consequence of the abnormal regression of paramesonephric derivative. In the past many different manifestations have been associated with the 46, XYq‐, anomaly. We discuss the possibility that a mullerian duct cyst may be one clinical manifestation of 46, X

ISSN:0919-8172    

DOI:10.1111/j.1442-2042.1994.tb00017.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY