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1. |
RODNEY PORTER 1917–1985 |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 1-2
César Milstein,
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ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01076.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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2. |
MOLECULAR ANALYSIS OF A CASE OF IgA2 DEFICIENCY |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 3-9
S. Oliviero,
M. DeMarchi,
B. J. E. G. Bast,
B. J. M. Zegers,
E. Van Loghem,
G. De Lange,
O. Carbonara,
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摘要:
SUMMARYA family with two members with selective IgA2 deficiency was analysed by direct gene analysis with different probes for theIgCHregion. No gross gene deletions or rearrangements were detected. Genetic analysis based on serological and molecular markers did not rule out linkage with theIgCHregion. However, a defect of other genes not linked to the Ig heavy chain region and controlling the expression of IgA may be possible as well.
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01077.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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3. |
INTERPLAY OF IMMUNOGLOBULIN G HEAVY CHAIN MARKERS (Gm) AND HLA IN PREDISPOSING TO SYSTEMIC LUPUS NEPHRITIS |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 11-17
V. Stenszky,
L. Kozma,
G. Szegedi,
N. R. Farid,
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摘要:
SUMMARYWe have studied the distribution of IgG heavy chain markers (Gm) among 90 Hungarian patients with systemic lupus erythematosus (SLE) (55 of whom were also typed for HLA). This study confirms previously described increases in HLA‐B8 and DR3 in this condition. No difference in the distribution of Gm phenotypes was found between patients and 168 controls from the same geographical area.HLA‐B8/Gmhomozygous individuals were, however, at greater risk for SLE (relative risk = 5.13) compared toB8+Gmheterozygotes orB8− individuals, irrespective of Gm phenotype. When patients with renal manifestation (n= 40) were compared to those without, the Gm phenotype 3; 5, 13 was found to be significantly increased (x2=10.36,P<0.0001, relative risk (RR) =4.69).HLAandGmincreased additively the risk for renal manifestations in that for those patients who were both Gm3;5,13+ and HLA‐B8+, PR was 110, while it was 21.2 for Gm3;5, 13−/B8+, 7.9 for Gm3;5, 13+/B8− and 1.0 for Gm3;5, 13−/B8− patients. The study suggests that combined HLA and Gm typing can be used to identify SLE patients at high risk for manifesting rena
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01078.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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4. |
PREFERENTIAL EXPRESSION OF CATFISH LIGHT CHAIN IMMUNOGLOBULIN ISOTYPES IN ANTI‐DINITROPHENYL ANTIBODIES |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 19-28
C. J. Lobb,
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摘要:
SUMMARYPrevious studies indicated that immunoglobulins of the channel catfish,Ictalurus punctatus, contained two distinct isotypes of light chains. These different light chains, designated F and G, are reminiscent of κ and λ light chains of higher animals. This study was undertaken to establish whether or not there was preferential expression of one of the light chains in antibodies induced to the dinitrophenyl moiety during the course of the catfish humoral antibody response. The results indicated that, although antibody produced very early (1‐2 weeks) after primary immunization contained significant amounts (∼20%) of G light chains, the vast majority (∼90%) of antibody produced later (3 weeks through 1 year) was of the F isotype. Thus fish, as well as higher vertebrates, can express different isotypes of antibody during the immune r
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01079.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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5. |
ELECTROPHORETIC ANALYSIS OF LIVER NEURAMINIDASE‐1 VARIATION IN MICE AND ADDITIONAL EVIDENCE CONCERNING THE LOCATION OFNEU‐1 |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 29-39
P. B. Samollow,
J. L. Vandeberg,
A. L. Ford,
T. C. Douglas,
C. S. David,
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摘要:
SUMMARYNeuraminidase‐1 (NEU‐1) is one of two neuraminidase isozymes which can be detected electrophoretically in mouse liver extracts. The inheritance of variation in NEU‐1 and the linkage relationships of the gene controlling this variation were studied through a backcross analysis involving the SM/J and MA/MyJ inbred strains, and by examination of NEU‐1 phenotypes in three congenic strains: Bl0.SM, Bl0.SM(22R) and B10.RVB. The data indicate that NEU‐1 is controlled byNeu‐1, a gene previously identified by its effect on total liver neuraminidase activity in whole tissue homogenates. Analysis of the congenic strains revealed identical low activity (SM/J‐type:Neu‐1α/Neu‐1α) NEU‐1 phenotypes in all three strains. This indicates thatNeu‐Ilies in the segment of the SM/J‐derivedH‐2region that is common to all three strains:H‐2EαtoH‐2D. In addition, we examined the relationship between NEU‐1 and phenotypic variation in liver acid phosphatase (AP; for which a new typing method is described) and linkage order among several other enzyme‐coding genes linked toH‐2. In all animals that could be scored confidently for AP, the NEU‐1 and AP phenotypes were concordant, adding support to the hypothesis that both phenotypes are controlled byNeu‐1. Recombination rates among six H‐2‐Linked marker loci were unexpectedly low, but were sufficient to verify the position ofUpg‐1as the telomeric flanking marker relat
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01080.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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6. |
A MONOCLONAL ALLOANTIBODY DETECTING A POLYMORPHISM OF THE RAT LEUCOCYTE COMMON (LC) ANTIGEN |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 41-50
M. R. Newton,
K. J. Wood,
J. W. Fabre,
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摘要:
SUMMARYA monoclonal antibody, NDS 58, was produced by fusing the rat myeloma line Y3 Ag 1.2.3 with spleen cells from AS rats immunized with LEW thymocytes. The determinant recognized by this antibody is leucocyte‐specific and present on all thymocytes, lymph node lymphocytes and some bone marrow cells. The strain distribution of NDS 58 was consistent with it being directed at the RT7aallele. Biochemical studies established that this antigen was carried on a cell surface glycoprotein with an apparent molecular weight on thymocytes of 190,000. This study confirms that the alloantigen originally designated Ly‐1, and now termed RT7, is an allodeterminant of the LC molecule, and the controversy in this area, particularly with regard to the ART‐1 alloantigen, is disc
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01081.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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7. |
ASSOCIATION OFBORDETELLA PERTUSSIS‐ INDUCED HYPERSENSITIVITY TO SEROTONIN WITH THEH‐2GENE COMPLEX |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 51-55
C. Teuscher,
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摘要:
SUMMARYSusceptibility toBordetella pertussis‐inducedsensitivity to serotonin was found to be associated with theH‐2gene complex in mice.H‐2congenic and independent strains which possess theH‐2bandH‐2shaplotypes were susceptible to serotonin sensitization by pertussigen (P‐HSF) while mice with theH‐2kandH‐2dhaplotypes were resistant. The gene or genes which control susceptibility were found to map to theH‐2SbDbend of theH‐2complex; susceptibility appears to be inherited as a co‐dominant trait. These findings indicate that HLA typing may be of value in predicting or interpreting possible adverse reactions to pertussis vaccine o
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01082.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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8. |
BOOK REVIEW |
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International Journal of Immunogenetics,
Volume 13,
Issue 1,
1986,
Page 57-58
J. H. EDWARDS,
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摘要:
Book Review in this articleM. W. Strickberger:Genetics. Collier Macmillan, New York, London. 1985. ISBN 0‐02‐418120‐X. Price
ISSN:1744-3121
DOI:10.1111/j.1744-313X.1986.tb01083.x
出版商:Blackwell Publishing Ltd
年代:1986
数据来源: WILEY
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