摘要:

SUMMARYSalivas from group B secretor or non‐secretor, acting on O red cells in the presence of UDP‐galactose, each converted them into B active cells, which were agglutinated against anti‐B human serum (1:512) at the titre of thirty‐two‐fold, while secretor or non‐secretor group AB salivas converted O red cells into B active cells, which were agglutinated by anti‐B human serum (1:512) at the titre of eight‐ to sixteen‐fold. The results indicate that the α‐galactosyltransferases which participate in the biosynthesis of group B substance are secreted in group B or AB salivas of both secretor and non‐secretor types as well as in their sera.Agglutinabilities of enzymatically converted B‐active red cells against anti‐B human serum indicate that α‐galactosyltransferase activities of both serum and saliva from a weak B (Bw) individual, who has weak B antigens in red cells and saliva, were lower than those of normal group B.The α‐galactosyltransferase activities in group Bmsera were lower than those of normal group B, while the enzyme activities in salivas of group Bmwere demonstrated to the same

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00567.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYFrom the variations of α‐N‐acetylgalactosaminyltransferases activities with the pH, evidence was obtained for the recognition of A1A2heterozygotes in normal A blood group sera.Besides, unusual transferase properties associated with two A2sera from individuals out of AAm1 siblings, lead to the identification of the very infrequent A2AAm1 genotypes. These results strongly support the simultaneous coexistence of both A1and A2transferases in heterozygotes' sera, and bring some new information on the genetical background of the Amphenotype.The meaning of transferase properties directly determined on whole sera is briefly discu

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00568.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEuonymus Sieboldianaseeds possess a lectin for human erythrocytes with anti‐B specificity. Lectin fractions with strong agglutinating activity were separated by ammonium sulphate precipitation from blood group H‐like substance, which is coexistent in the same seeds. The lectin has properties resembling a complete agglutinin, being non‐dialysable, inactivated by heat treatment at 70°C and specific for D‐gal

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00569.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYA number of families with an established recombination in the major histo‐compatibility complex has been investigated for markers known to be coded by genes of this linkage group. The results provide further data on the relative position of the loci for HLA‐A, HLA‐B, HLA‐C, HLA‐D, Bf, Chido, Rodgers and PGM3on chromosome 6. A positive lodscore for linkage betweenHLAand blood groupPwas found; lodscores betweenHLAand nineteen other markers were

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00570.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe possession of the histocompatibility antigen HL‐A8 has been correlated with serum levels of antibodies to gluten and a variety of other dietary, viral, and bacterial antigens and autoantigens. The only significant correlation with HL‐A8 was of raised levels of gluten antibody. Thus it seems that HL‐A8 may be associated with an enhanced immune response specifically to gluten, and not with a generally enhanced immunological responsiveness as has been sugg

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00571.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe relationship between the mixed leucocyte reaction (MLR) and the serologically‐defined antigens controlled by genes in the guinea‐pig B locus (equivalent to the murine D or K region) and I region was investigated in various inbred and partially inbred strains and in guinea‐pig families homozygous for their GPLA alleles. No MLR reactions could be detected among guinea‐pig families of a closed colony which had been bred to homozygosity for their GPLA antigens. By contrast, animals which differed in their I region showed strong MLR reactivity. Animals with identical I regions as judged by four serologically‐defined specificities only, but differ with respect to B locus determinants, yield appreciably lower MLR responses. It appears that in the guinea‐pig, as in other mammalian species, the antigenic systems responsible for MLR reactivity are controlled primarily by genes identical with or closely linked to the I region of the major histocompatibil

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00572.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYThe immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H‐2 loci and the 2 non‐H‐2 loci ‘Tla’ and ‘Theta’ and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR‐genes or with a cross tolerance hypothesis requiring no

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00573.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARY‘Natural’ antibodies are generally believed to possess solely 2H‐2L immunoglobulin structure. They have many disulphide bonds, the structural importance of which is not yet understood.However, some natural heterohaemagglutinins in the sera of some lower vertebrates (eel, shark, perhaps also trout and toad) are subunit proteins; the subunits are held together not by disulphide bonds but solely by non‐covalent interactions like animal lectins.The relevance of these findings for immunophylogeny is di

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00574.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYIn two members of a Czech family a weak W 27 antigen was found. The lymphocytes of the two individuals showed an identical positive cytotoxic reaction only with some sera having anti‐W 27 specificity; anti‐W 27 of both the said sera and those showing negative cytotoxic test was absorbed by the lymphocytes. The thrombocyte absorption capacity was substantially poo

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00575.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Book Review in This ArticleThe Role of Natural Selection in Human Evolution, Edited by FranciscoM. SalzanoHuman Variation and Natural Selection, Edited by D. F. RobertsLactic Dehydrogenase Virus, K. E. K. Rowson, B. W. J. Mahy

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00576.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY