摘要:

SUMMARYThe Gm, Am and Km immunoglobulin allotypes and ABO blood groups were studied in three groups of Tunisian Berbers.The results showed that the actual Berbers of Tunisia present certain heterogeneity and their ancestors were probably the first inhabitants of North Africa. Indeed, although theirGm‐Amhaplotypes are mainly Caucasoid, some of them are typically African.The group of Kesra village, the most Caucasoid, shows frequencies ofGm‐Amhaplotypes very close to those of South European populations, particularly the Spanish, who are probably of the same origin. The gene frequencies of the ABO groups in the three Berber groups were similar to those recorded in European populations with a relatively high frequency of the O genes typical of the Berb

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01044.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYNo Gm allotype, haplotype or phenotype was increased or decreased in frequency in two autoimmune diseases, rheumatoid arthritis (RA) or chronic active hepatitis (CAH) in comparison with control frequencies. The frequencies of the Gm haplotypes among 206 controls were 0.70, 0.19 and 0.11 forfb, agandaxg, respectively. NeitherGmheterozygosity nor homozygosity was associated with either disease. There was no interaction between α1‐antitrypsin (PI) and Gm type in the two diseas

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01045.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYSpleen cells from Balb/c mice given multiple injections of intact human erythrocytes (group O, NN) were fused with NS1 myeloma cells. Culture fluids from the resulting hybrid cells were screened for agglutinating antibody against a panel of erythrocytes. One cell line, 2/23, secreted an IgM antibody which reacted more strongly with NN than with MM cells. Neuraminidase or papain treatment of erythrocytes abolished agglutination whereas trypsin treatment did not. Reactions with U‐erythrocytes of different MN phenotypes confirmed the anti‐N specificity of monoclonal antibody 2/23. This is the first report of monoclonal anti‐N stimulated by the immunization of mice with intact erythro

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01046.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYMonoclonal antibody 212.i.4.2 mediated complement‐dependent lysis of spleen and lymph node cells carrying thetw1, tw12, tw71, t6, tw73, andtLub1haplotypes, while cells from mice carrying 11 otherthaplotypes were not lysed. The antibody also detected an epitope controlled by genes in theH‐2Ddregion of non‐t mice. A molecule of 46,000 molecular weight was immunoprecipitated by 212.i.4.2 from detergent extracts of125I‐labelled spleen cells of +/tw12and B10.D2 mice. The H‐2dm2mutation did not alter the expression of the epitope recognized by 212.i.4.2. However, the H‐2dm1mutation decreased the reactivity of lymphoid cells with the antibody in cytotoxicity tests, and 212.i.4.2 immunoprecipitated little or no protein from extracts of B10.D2(R106) spleen cells which carry the H

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01047.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYSpleen cells from 30 individual murine irradiation chimeras of the type (P1 x P2)F1→ P1 were compared in a rosetting assay for H‐2K and H‐2D cell surface antigen expression with normal (P1 x P2)F1hybrid controls. Eleven out of the 30 chimeras were in the normal range, but the other 19 differed from F1controls by 4‐ to 100‐fold in endpoint titre for at least one H‐2K or H‐2D antigen. Every possible class of variation was found, i.e. up or down variation of H‐2K or H‐2D antigens of P1 or P2 type. This evidence, together with data fromT6chromosome marker experiments which also showed full reconstitution of lethally irradiated P1 recipients by (P1 x P2)F1donor lymphomyloid stem cells, suggested that incomplete reconstitution was not the cause of H‐2 antigenic variation.Low expression of P2 H‐2 antigens on spleen cells derived from (P1 x P2)F1→ P1 chimeras was investigated further. Fifteen lethally irradiated (P1 x P2)F1recipients of bone marrow cells from two such chimeras were all of normal F1H‐2 phenotype when tested 10‐12 weeks after reconstitution, thus excluding stable, low P2 H‐2‐expressing variant F1stem cells as a cause of the phenomenon. If P1 recipients were hyperimmunized against P2 cells before lethal irradiation and reconstitution with (P1 x P2)F1stem cells, there were significantly fewer Till‐McCulloch colonies in their spleens 10 days after reconstitution than in spleens of unimmunized controls. Also>90% of immunized recients died by 6 weeks after stem cell injection but two survivors both showed very low levels of P2 H‐2K and H‐2D antigens. These results together with previously published evidence of anti‐P2 Tc cell activity and P2 skin graft rejection in (P1 x P2)F1→ P1 chimeras suggested that residual anti‐P2 immunological capability in lethally irradiated P1 recipients may be associated with low P2 H‐2 expression on their F1‐derived spleen cells, although the mechanism does not involve selection of stable, variant F1stem cells. The mechanism(s) of other classes of variation in H‐2 expression

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01048.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYRNA was extracted from the splenocytes ofBrucella abortusantigen stimulated mice and of control mice. The proportion of chromatographically separated polyadenylated 11.2S mRNA, was determined. With the technique used, only stimulated mice exhibited significant amounts of this RNA species. The highest level was reached 1 day after the stimulation, and the decay from this level presented an oscillatory form during the 4 weeks following the injection.In two different genetic backgrounds,H‐2bmice did not respond to the stimulus, in contrast toH‐2aandH‐2fmice.H‐2b/H‐2fheterozygotes behaved roughly as intermediate betweenH‐2bandH‐2fmice. This genetic control seems to parallel the genetic control of someBrucella‐induced, thymus‐dependent events pre

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01049.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYThree recessive lethalthaplotypes have been independently isolated from widely separated Chilean wild mouse populations. They do not complement one another, have similar transmission ratios and suppress recombination. We do not know at present if they belong to a previously described complementation group or if they define a new one.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01050.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYSerum samples were collected from 30 healthy adult Caucasian volunteers before and after immunization with native type III polysaccharide of group B streptococcus. Serum antibody to this polysaccharide was measured and sera were typed for severalGmandKm(1) allotypes. A significant interactive effect ofGm(23) andKm(1) was found on immune responsiveness to native type III group B streptococcus polysaccharide antigen.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01051.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYInvestigation of an informative family including two probands with male multiplex retinitis pigmentosa revealed that the putative disease susceptibility loci were not linked to those of HLA. In addition, analysis of immunological data obtained yielded evidence suggestive of X‐linked inheritance of susceptibility to cell‐mediated immune aberration in this fam

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01052.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Book Reviews in this ArticleR. WITKOWSKI and O. PROKOP: Genetik erblicher Syndrome und Mgbildungen. Worterbuch fur die Familienberatung.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1984.tb01053.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY