摘要:

SummaryThe study of the distribution of IgG subclasses in a group of Iraqi Arabs has revealed marked elevation in the levels of IgG3 associated with low levels of IgG1. Furthermore, individuals homozygous for the G3m(b) marker were found to have significantly higher levels of IgG3 than individuals heterozygous for this marker. Results are discussed in relation to other similar reports.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00785.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryThe following attributes of the immune response were studied from nine patients with different numbers of X chromosomes: serum immunoglobulin levels, C3and C4concentrations, the presence of autoantibodies, phagocytosis, killing of bacteria, the chemotactic response of neutrophils. thein vitroresponse of lymphocytes to PHA, ConA, PwM, PPD and oidiomycin; and the proportion of T lymphocytes was determined. The number of X chromosomes varied from one (45,X) to four (48,XXXX). No evidence of severe dysfunction in the immune system was found in any of the patients. The correlation coefficients between the serum concentration of IgM and IgG and the number of X chromosomes present were statistically significant (r = 0.691, P<0.05, and r = 0.714, P<0.05, respectively). The serum IgA concentration showed a tendency towards a negative correlation. The concentrations of neither IgD nor IgE correlated to the number of X chromosomes. It seems obvious that the number of X chromosomes is positively associated with the concentration of serum IgG and IgM. The results support the hypothesis that antibody production is at least partially controlled by genes located in the X chromosome.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00786.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySeveral Gm, A2m, and Km allotypes were examined in Caucasian patients with giant cell arteritis and polymyalgia rheumatica. No significant associations were found for any of the allotypes tested.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00787.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryA group AB mother (Mrs P.D.) gave birth to a group O female baby (C.D.). Extensive study of the blood group genetic markers in both the parents and the child, carried out on several occasions, showed nothing unusual outside the ABO system. Mrs P.D. then, gave birth to a second female baby who was also group O. Mrs P.D. had normal amounts of A, B, H and Lewis antigens in her saliva. The H, A and B agglutinability of her red cells was in the range of normal A2B group. This A2B blood group was characterized by very low A gene‐specified glycosyltransferase activity in serum. Moreover this activity was undettable in red blood cell membranes. These results are discussed in the light of various hypotheses in order to explain this unusual transmission of ABO blood grou

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00788.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryBecause of the inconsistency in published results concerning the serological detection of cell surface antigens coded for by thet‐complex, a cell‐mediated lymphocytotoxicity (CML) assay, secondary CML, was used in a search fort‐antigens. By sensitizing C3H.Ttf(C3H. Brachyury, tufted) with the congenic strain C3H.Ttf/tw18splenic cells, a response against lipopolysaccharide (LPS) stimulated splenic cells from C3H.Ttf/tw18mice is obtained. The locus coding for the antigen detected by this reaction lies to the left oftfon the murine seventeenth chromosome. The secondary CML response to this antigen isH‐2restricted and detects an antigen on allt‐haplotypes tested:tw18, tw18tf, t12, t6, th2tf

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00789.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryFour OLA factors of the ovine histocompatibility complex and the OLX‐5 factor were recognized in hamster cell x sheep fibroblast hybrids, by means of absorption of OLA reagents with hybrid cells. Segregation of these factors could be studied in eighteen independent hybrids. In the case described, the four OLA factors were distributed into two haplotypes isolated in some hybrids. The heterozygous OLX‐5 factor was linked to only one haplotype; nevertheless a dissociation, occurred in one hybrid (relative to five simultaneous transmissions), is in agreement with a previous genetic study showing a loose linkage between the OLA complex and theOLXlo

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00790.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySelective breedings of mice were carried out for quantitative antibody responsiveness to flagellar Ag., f (Selection III) or somatic Ag., s (Selection IV) of two non cross‐reaction Salmonellae (Salm. tm., Salm. or.) alternated for immunization of consecutive generations. At the selection limit, these selections produced homozygous high (H) and low (L) responder lines for the character investigated: peak agglutinin response to optimal secondary immunization. The responsiveness to both f and s Ags. is submitted to polygenic regulation. The heritability (h2) realized during the selective breeding was 0.37 ± 0.07 for the response to f Ag. and 0.40 ± 0.1 for the response to s Ag. The respective part of genetic and environmental variance in F2hybrids was 64% and 36% in selection III and 61% and 39% in selection IV. In the two selections, the dominance variance is negligible (<1%), therefore the genetic variance is essentially additive. The additive variance calculated as the heritable fraction of the F2hybrid variance is somewhat lower, the reason for this difference is discussed. The quantitative antibody response to f Ag. in selection III is controlled by about seven independent loci. The antibody response to s Ag. in selection IV is controlled by about four independent loci. A possible association of relevant genes with theH‐2locus was investigated. In selection III, no significant participation ofH‐2linked genes, in the regulation of responses to f and s Ags. ofSalm, tmandSalm. or.could be demonstrated. In selection IV a partial contribution ofH‐2linked genes was observed concerning responsiveness to both f and s Ags. ofSalm. tm.. but not toSalm. or.Ags. The H‐2 effect accounts for 25% of the total interline

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00791.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryD. G. HARNDEN, J. E. LINDSTEIN, K. BUCKTON AND H. P. KLINGER; An Interriational System for Human Cytogenetic Nomenclature. High‐Resolution‐Band

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00792.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY