摘要:

SUMMARYIn a case of chimaeric male twins which showed red and white cell chimaerism, the latter being demonstrated using polymorphism of autosomes, it could be shown that the determinant RB, being defined by lymphocytotoxicity and associated with ABO blood groups and ABH secretor status, is probably absorbed from the serum on to the lymphocyte surface and not produced by the cells themselves.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00597.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYHaemagglutinins which specifically combine with membrane determinants of human blood group A erythrocytes and which are distinguishable from any other haemagglutinin specificities display marked sex dependency in C57BL/10 mice. All the sera of 80‐day‐old C57BL/10 females exert moderate to strong anti‐A haemagglutinin activities which could be detected only in approximately half of the sera of the males of the same age. Investigations of the murine tissues revealed that the production of anti‐A haemagglutinins in females is reflected by simultaneous synthesis of strong endogenous receptors detected in the ovaries and associated with water‐soluble glycolipid fractions. The receptor activity was demonstrated by means of haemagglutination inhibition in comparison with appropriate controls and glycolipid preparations from seventeen other different male and female tissues, and the inhibitory effects exerted by the ovarian glycolipids were statistically significant on the basis of multiple comparisons at the 1% level in each possible pair o

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00598.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEn(a‐) andEnaEnred cells from different sources were studied using biochemical and serological methods. The results suggest that Finnish En(a–) erythrocytes contain only ‘N’ but no M antigenic properties. Data on the members of the English En(a‐) family suggest that English En(a‐) red cells exhibit a combination of three rare alterations. The English En(a–) individuals are apparently heterozygous for the defects En and Mk. In addition, the ‘N’ receptor on the Ss glycoprotein is, to all appearances, converted to a M (‘M’) antigen. These extraordinary data are brought to light by investigations on the children of the propositus (G.P. and J.P.), whose red cells are M‐N+S‐s+‘N’+‘M’‐ and M‐N+S+s+‘N’+‘M’+ respectively. Sodium dodecylsulphate polyacrylamide gel electrophoretic results indicate that the MN glycoprotein content is decreased by about 50 % in all English S+s+EnaEnred cells, the Ss glycoprotein being normal. G.P. erythrocytes, however, have only about half

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00599.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00600.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEggs of threeBufospecies (B. bufo, B. viridisandB. calamita) were examined for blood group activity.B. bufoshowed distinct A activity, whereas inB. viridisandB. calamitaa marked H‐activity was observed. These results correspond with the zoological systematic classification of the three toad species teste

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00601.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYImmunogenetic (IR‐gene) systems consist of animals showing different quantitative antibody responses when immunized with similar doses of a given antigen.Strains of animals giving high and low antibody titres are described as high and low responders, respectively.The degree of dominance in F1 hybrid strains, obtained from a cross between high and low responder parents, can readily be calculated using the dominance index formula, which takes the value of +1 for complete dominance, ‐1 for complete recessivity and the value of zero for no dominance.In reviewing 1527 F1 animals, obtained from ninety‐one immunogenetic systems, the degree of dominance (d) was found to be: + 0±0076 ± 0±1053 (mean ± s.e.), which is close to a value of zero and this is consistent with codominant inheritance.It is suggested that in immunogenetic systems, both alleles are expressed as co‐dom

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00602.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEarly embryo aggregation derived mouse chimaeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically predestined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible ‘correction’ of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially ‘deficient’ anaemias and tumours have been studied–the subject of the re

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00603.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYEarly embryo aggregation derived chimaeras have proven a valuable tool to biologists concerned with various aspects of mammalian development. The use of this model is discussed here in respect of its application to the field of immunogenetics and also to possible future exploitation. Chimaeras have already provided information concerning various areas of immunogenetics ranging from tolerance, control of antibody response, allotype expression, gene transfer and its possible influence upon the immune response. These are reviewed here.

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00604.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SUMMARYModifications of HLA antigens (transient loss or polyreactivity) were found in thirty‐two of fifty‐five examined patients with blood diseases (leukaemia, reticulosis, reticulo‐ and lymphosarcoma, lymphogranuloma, erythroblastoma) and malignant tumours. In two cases of acute myelosis transient alteration of HLA‐A 2 antigen in HLA‐A 28 was demonstrated. The relationship of HLA antigenic modification to chemotherapy was established, both by analysis of individual cases and by statistical evaluation of serological results in patients with or without chemotherapy (0.01

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00605.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A nomenclature committee composed of geneticists and immunologists, including specialists in tissue typing, has met after each of the histocompatibility workshops beginning with the third workshop in 1967. The Committee in part under the auspices of World Health Organization and International Union of Immunological Societies (WHO‐IUIS), met after the sixth workshop in Århus in July 1975. The expanding knowledge of the genetics of the major histocompatibility system of man has necessitated a revision of the terminology for the HLA region following the principles established in previous reports. This has been done with as few changes as possib

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1976.tb00606.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY