摘要:

SUMMARYThere is considerable evidence that at least some cases of juvenile onset diabetes mellitus in humans are a result of viral infection. Viral-induced diabetes in mice may provide an experimental counterpart more similar to the clinical situation than chemical-induced diabetes. Our experiments in such mice indicate that islet transplantation is effective in ameliorating viral-induced diabetes and is encouraging for ultimate clinical application of islet transplantation to juvenile onset insulin-dependent diabetics. In addition, our results show that islets in ectopic sites outside of the pancreas are resistant to damage induced by primary viral infection. The mechanism of this resistance is obscure and will be the subject of future investigations.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SUMMARYThe extremely sensitive peritoneal exudate cell (PEC) transfer technique has been applied to an investigation of the immune response of female mice which are “tolerant” of the male antigen. Females rendered tolerant of male skin grafts by multiparity, neonatal inoculation of male spleen cells, or multiple inoculations of adult females with male lymphoid cells displayed second-set reactivity to male PEC while continuing to tolerate H-Y-incompatible skin grafts. Furthermore, this discordant response to male PEC and skin was adoptively transferrable to normal females by spleen cells from multiparous donors. Females rendered tolerant by irradiation and reconstitution with male cells were unresponsive to both H-Y-incompatible skin and PEC grafts. A model is proposed using two male-specific antigens, the response to which is controlled by independent genes.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SUMMARYThere have been several reports of observations which suggest that transplantation tolerance may be a result of positive immunoregulation rather than simply unresponsiveness attributable to a lack of competent effector cells. In particular, several investigators have reported that tolerance of the H-Y and H-1 histocompatibility antigens is mediated by a population of thymus-derived lymphocytes. In a companion report, we have presented evidence that supports the existence of a suppressor cell to the H-Y antigen. Futhermore, we have observed that female mice rendered tolerant of the H-Y antigens by neonatal exposure to male lymphoid cells or by multiparity accept male skin grafts indefinitely, but inactivate male peritoneal exudate cells (PEC) in a second-set fashion. This observation has led us to investigate whether tolerance of other non-H-2 antigens is controlled by a similar mechanism. Using mice congenic with C57BL/10 at the H-4 and H-7 loci, we have shown that mice rendered tolerant of the H-7aand H-4bantigens by neonatal exposure to histoincompatible lymphoid cells are incapable of rejecting either skin or peritoneal cell allografts, suggesting that identical histocompatibility antigens are present on skin and peritoneal cells. Tolerance induced in neonatal mice to the H-4band H-7aantigens could not be adoptively transferred to syngeneic recipients. These results suggest that tolerance involving the H-4 and H-7 antigens is most likely because of a clonal inactivation of alloantigen-reactive cells as a consequence of neonatal exposure to antigen.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID