摘要:

The distribution of the histocompatibility antigens responsible for positive antiglobulin consumption reactions have been studied along with some of the antigens' characteristics. These antigens are present in highest concentration in liver, with kidney being second, muscle and brain third. Little if any were found in spleen and lymph nodes, and none in endocrine tissue. The antigens were found to be rendered nonreactive by lyophilization, repeated freezing and thawing, and heat of 56C for 45 minutes.

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

摘要:

A series of five experiments on histocompatibility gene mutation as detected by tail-skin graft tests in isogenic mice has been completed. To explain the results it is hypothesized that the observed histocompatibility changes were the result of the incorporation of viral genomes into germinal cells of parents in a manner paralleling the phenomenon of lysogeny in bacteria. This hypothesis would explain why most changes were gains in antigen, why paternal X-irradiation had no detectable augmenting affect on incidence, but why the environment in which the parents were born and raised did seem to affect the incidence. The hypothesis is extended to explain the origin and function of the histocompatibility and blood-group genes.

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

摘要:

Most C57BL/1 female mice normally reject male skin grafts. Tolerance to male skin grafts is induced in C57BL/1 female mice in most instances by the injection of cell-free tissue preparations obtained from spleen, liver, kidney, lung and heart. The potency of disrupted tissue preparations is generally well preserved by storage of tissue at deepfreeze temperatures for periods of 2–6 months. A notable exception to this observation in our experiments were the preparations of strored spleen. Tolerance to male skin grafts may be induced in the majority of C57BL/1 female mice by a single injection of 200–400 mg of cell-free antigenic material prepared from liver, spleen, kidney, heart and lung tissue as well as by the series of injections originally used which involved in aggregate 900 mg wet weight tissue equivalent. In the case of liver tissue, the administration of as little as 100 mg of cell-free antigenic material in a single injection has produced a high incidence of tolerance and a perceptible effect has been noticed at doses as small as 10 mg.

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1966

数据来源: OVID