11. |
PROLONGATION OF CANINE RENAL ALLOGRAFT SURVIVAL BYL-ASPARAGINASE |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 217-222
F T Rapaport,
T Shimada,
K Watanabe,
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摘要:
SUMMARYRecent reports indicate that L-asparaginase may affect the normal function of immunologically competent cells and/or their precursors and may prolong the survival of skin allografts and heterografts in mice and rabbits. In the present study, 31 mongrel dogs received renal allografts from randomly selected donors. They were treated with 150-200 international units of crystalline L-asparaginase/kg/day for 9-21 days after transplantation, and the results were compared with 79 control renal allografts performed without treatment in the same population. The mean survival time (MST) of renal allografts in L-asparaginase-treated animals was 15.64 ± 7.39 days; 3% of the transplants were rejected by the 9th day, and 32% survived for more than 16 days. The longest survival was 43 days. In contrast, the MST of the control allografts was 10.81 ± 3.38 days; 40% of the transplants were rejected by the 9th day, and only 5% survived for more than 16 days. The longest survival was 25 days. The prolonged renal allograft survivals observed in L-asparaginase-treated animals were associated with morphological evidence of a slowing of the allograft rejection response, with decreases in the intensity of the cellular infiltrates (which consisted mainly of macrophages) and with a paucity of lymphocytes. A number of histological changes compatible with a chronic type of renal allograft rejection were observed in these recipients. The results suggest that L-asparaginase may merit further consideration with regard to its possible usefulness as an immunosuppressive agent in renal transplantation.
ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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12. |
STUDIES ON DNA TRANSFER FROM DONOR TO HOST TISSUES IN MICE |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 223-223
R G Devlin,
G M Ramm,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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13. |
A CASE OF CROSSING OVER IN THE HL-A SYSTEM |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 224-225
J Seignalet,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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14. |
THE Mo55 ANTIGEN, AN ALLELE AT THE FIRST HL-A LOCUS |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 225-227
J Seignalet,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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15. |
RENDERING MACROPHAGES SPECIFICALLY CYTOTOXIC BY A FACTOR RELEASED FROM IMMUNE LYMPHOID CELLS |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 227-229
R Evans,
P Alexander,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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16. |
THE ROLE OF CYCLIC AMP IN THE IMMUNOCOMPETENT CELL |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 229-231
Hugh Watts,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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17. |
Θ ANTIGEN ON MOUSE LYMPHOCYTES STIMULATED WITH PHYTOHAEMAGGLUTININ |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 231-234
John Owen,
Penny Hunter,
Martin Raff,
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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18. |
A51CR MICROCYTOTOXICITY TEST |
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Transplantation,
Volume 12,
Issue 3,
1971,
Page 234-235
K I Welsh,
P Cresswelli,
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PDF (105KB)
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ISSN:0041-1337
出版商:OVID
年代:1971
数据来源: OVID
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