11. |
PROLONGATION OF LIVER ALLOGRAFT SURVIVAL BY DONOR‐SPECIFIC SOLUBLE TRANSPLANTATION ANTIGENS AND ANTIGEN‐ANTIBODY COMPLEXES |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 64-70
J.,
MYBURGH J.,
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摘要:
Soluble transplantation antigens were prepared from chacma baboon spleen cell membranes by a modified 3 M KC1 technique. The extracts were soluble according to usually accepted criteria. Molecular weight was 37,700 daltons. Antigenicity was confirmed by inhibition of cytotoxicity of alloantibody. The antigens stimulated sensitized lymphocytes in culture but failed to stimulate unsensitized lymphocytes. Antigen-antibody complexes were assembled in vitro in the regions of equivalence and marked antigen excess. Administration of a single dose of soluble donor antigen at the time of orthotopic liver allotransplantation prolonged graft survival significantly. Concomitant administration of a polyspecific alloantibody, previously shown to prolong baboon liver allograft survival, abrogated the graft prolongation produced by the antigen or antibody given alone. When the administration of the soluble antigen was preceded by a dose of cyclophosphamide (20 mg/kg), graft prolongation was slightly curtailed. Antecedent administration of azathioprine and prednisolone for 3 days seemed to render the antigen immunogenic in that liver allograft rejection was accelerated. Antigen-antibody complexes at equivalence prolonged liver allograft survival beyond that seen with antigen alone, but complexes in marked antigen excess were immunogenic, inasmuch as graft survival was not prolonged and the histological features were those of accelerated rejection.
ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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12. |
ERRATUM |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 71-71
&NA;,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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13. |
INTRAUTERINE THYMECTOMY IN GUINEA PIGA TECHNICAL REPORT |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 72-73
JUHANI MERIKANTO,
OLLI RUUSKANEN,
BJÖRN THOMASSON,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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14. |
HETEROTRANSPLANTATION OF INVERTEBRATE ORGANS TO CONGENITALLY ATHYMIC (NUDE) MICE |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 74-76
Michel Leclero,
Jacqes Panijel,
Kyoto Toyama,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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15. |
ACTIVATED MACROPHAGES AS CYTOTOXIC EFFECTOR CELLSI. INHIBITION OF SPECIFIC AND NONSPECIFIC TUMOR RESISTANCE BY TRYPAN BLUE |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 77-80
JOHN HIBBS,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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16. |
ACTIVATED MACROPHAGES AS CYTOTOXIC EFFECTOR CELLSII. REQUIREMENT FOR LOCAL PERSISTENCE OF INDUCING ANTIGEN |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 81-86
JOHN HIBBS,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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17. |
CELLULAR CYTOTOXICITY ASSAYS DETECT DIFFERENT EFFECTOR CELL TYPES IN VITRO |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 87-90
David Scollard,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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18. |
THE EFFECTS OF PREGNANCY ON THE IMMUNOLOGICAL COMPETENCE OF CONGENITALLY ATHYMIC (NUDE) MICE |
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Transplantation,
Volume 19,
Issue 1,
1975,
Page 91-91
D. Humber,
M. Pinder,
C. Hetherington,
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ISSN:0041-1337
出版商:OVID
年代:1975
数据来源: OVID
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