摘要:

SUMMARYThe behavior of BALB/c myeloma transplants in (C57BL/ 10 BALB/c) F1hybrids was investigated. The F1hybrids were less susceptible to the grafts than were the parental BALB/c hosts. Host susceptibility was X-ray and cyclophosphamide sensitive, but an immune hypothesis was not favored since no memory was demonstrable. Males were less susceptible than females, and rabbit antithymus serum had no effect on susceptibility.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SUMMARYThe genetics of hybrid susceptibility to parental myeloma transplants in histocompatible F1hybrids was investigated. Various inbred mouse strains and their descendant congenic lines were crossed with BALB/C mice to produce appropriate F1hybrids. Genetic inferences were drawn from the comparison of the frequencies of tumor graft takes among congenic combinations. Hybrids containing the C57BL/10 genetic background were less susceptible to myeloma transplants than were hybrids of other genotypes. Both H-2-associated and non-H-2-associated genetic factors played significant roles in determining host susceptibility to the transplants. The D end of the major histocompatibility complex did not play a predominant role in determining hybrid susceptibility in C57BL-derived F1hybrids.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SUMMARYTo define the relationship of donor-specific B lymphocyte alloantibodies to renal allograft survival, longitudinal serum samples obtained pre- and post-transplantation were examined for antibodies cytotoxic to donor B lymphocytes. Ten of 17 renal allograft recipients had antibodies to donor B lymphocytes but not T lymphocytes either pre- and/or post-transplantation. Three patients underwent successful transplants despite preformed B cell antibodies; however, seven who developed B cell antibodies only after transplantation are either undergoing chronic rejection (4) or have had severe rejection crisis (3). Seven patients with no B cell antibodies have functioning grafts. In all cases, B cell antibodies were detected before biochemical and clinical evidence of rejection. Similar findings were noted when sera of 38 renal transplant recipients were examined for B cell antibodies cytotoxic to an unrelated panel of B lymphocytes. These results demonstrate that the development of B cell alloantibodies after transplantation is often associated with rejection and that successful renal transplantation can be performed across a positive B cell crossmatch.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

SUMMARYSeventy-four recipients of related donor renal allografts were tested for the presence of cellular immunity to specific donor lymphocyte antigens using the direct migration inhibition factor (MIF) assay. Responses on the assay fell into one of the following three statistically distinct groups: (1) greater than 20% inhibition of macrophage migration, (2) nonresponsiveness, 10% of control migration, and (3) greater than 12% stimulation of macrophage migration. Migration stimulation was shown to be reproducible and to correlate well with a very benign post-transplant clinical course. The production of migration stimulatory factor appears to be an immunological response analagous to the production of migration inhibition factor.

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1979

数据来源: OVID