摘要:

CD complex response to cessation of induction with OKT3 may be predictive of rejection. Twenty-seven patients receiving renal allografts and OKT3 induction immunosuppression were retrospectively analyzed for CD complex repopulation and allograft rejection. Flow cytometric monitoring was utilized in all patients. Responder status groups were identified based on CD complex repopulation, with fast responders demonstrating CD complex repopulation above the determined cohort mean. Slow responders had repopulation below this mean. Student'sttest yieldedP<0.01 (CD2),P<0.02 (CD3), andP<0.01 (CD8). Nonresponder patients were identified with repopulation below the mean, but flat compared with depletion. All nine fast responders lost their graft or were treated for rejection. No slow responder experienced graft loss or rejection episodes. One nonresponder was treated for rejection. CD complex activity following OKT3 cessation correlates with future rejection. Identification of responder status provides insight into propensity to reject, allowing individual tailoring of immunosuppression to patient response.

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The first well-documented case of recurrent type III membranoproliferative glomerulonephritis after kidney transplantation is reported in this article. A 48-year-old man was admitted to the hospital because of nephrotic syndrome and moderate renal failure. The renal biopsy showed double-contour images at light microscopy. Electron microscopy revealed electrondense deposits in the mesangium and in both the subepithelial and subendothelial sides of the basement membrane. Subepithelial deposits were sometimes hump-like and produced an irregular disruption of the lamina densa. A diagnosis of type III membranoproliferative glomerulonephritis was suggested. The patient had a rapid decrease in renal function and received dialysis in 3 months. Three years later, he received a cadaveric kidney transplant, and subsequently recovered normal renal function. Proteinuria appeared after 13 months, and a biopsy of the graft demonstrated recurrence of the original disease. Seven years after transplantation, he returned to hemodialysis.

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Background.Infection withNocardiaspecies is an increasingly recognized complication of solid organ transplantation.Nocardia asteroidesaccounts for most transplant-related nocardiosis, whileNocardia brasiliensisrarely causes infection in organ transplant recipients.Methods.We describe a case of disseminated infection withN brasiliensisin a single-lung transplant recipient who also had concomitant infections with viral and fungal organisms.Results.Although the mortality rate is high in immunocompromised patients with disseminatedNocardiainfection, our patient responded favorably to prolonged antimicrobial therapy.Conclusions.This case illustrates thatN brasiliensis,likeN asteroides,produces pulmonary disease and dissemination in solid organ transplant recipients, and demonstrates the utility of prolonged treatment with trimethoprim-sulfamethoxazole inNocardiainfections.

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID