摘要:

Background.The terminal Galα1,3Galactose (αGal) determinant is present on all porcine glycoproteins and glycolipids, but is not expressed by human cells. Consequently human sera contain anti-αGal natural antibodies. The human blood group B antigen [Gal α1,3(Fuc1,2)Galactose] is differentiated from the αGal epitope by the presence of a fucosyl group.Methods.To determine whether the expression of the B antigen has any effect on the level of αGal-reactive natural antibodies, equal numbers (n=12) of A, B, AB, and O serum samples were evaluated by ELISA and flow cytometry.Results.A significant reduction in IgG αGal reactivity was observed with serum samples from B antigen-expressing donors (B, AB) relative to non-B antigen-expressing donors (A, O).Conclusions.These results are consistent with the possibility that anti-αGal antibodies in non-B antigen-expressing individuals include a subset that is reactive with the structurally related B antigen and that this subset is absent in B and AB individuals.

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

We assessed the long-term rehabilitation and quality of life after kidney transplantation in 17 recipients of transplants during their childhood who had reached 10 years or more after grafting. We found that all recipients considered themselves to be in good to excellent health, and 59% were completely satisfied with their life. Ninety-four percent of the recipients did not report any interference of their health with their family life. Only one recipient was unemployed, and five recipients have to miss work (n=2) and school (n=3) a few days a year due to their health status. Health seldom or never interfered with social life in 11 recipients, and in 6 of 9 sexually active recipients, their health status was not an obstacle in their sexual relationships. Two recipients expressed concerns about their short stature, and three were concerned with their body appearance.In conclusion, we describe a group of young adult recipients who presented a highly satisfactory rehabilitation and quality of life after their successful transplantation.

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1997

数据来源: OVID