摘要:

Lymph node cells from female bm-1 donors induced greater mortality among male than female (bm-1 b)F1hosts which had previously been sublethally irradiated. The same effect was not seen when wild type (b) parental donor cells were injected, nor in other combinations involving H-2K mutant C57BL/6 mice. The selective mortality encountered among male hosts in receipt of bm-1 female cells was shown to depend upon recognition of H-Y in the recipient, because this sex effect disappeared if the donors were first rendered tolerant of H-Y. However, absence of graft-versus-host (GVH) mortality with other combinations indicated that recognition of H-Y alone was not sufficient. When cells from donors tolerant of H-Y were mixed with cells from donors tolerant of H-2Kb, enhanced mortality among male F1hosts was again observed. We interpret the results to indicate that there is a synergistic interaction of donor lymphocytes which recognize H-Y and H-2Kbduring the GVH response.

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Negro recipients appear to have essentially the same graft and patient survival rates as Caucasian recipients after accounting for the center effect. Cadaver kidneys from Negro donors yielded very slightly lower survival rates than kidneys from Caucasian donors after correction for the center effect. It appears that centers with poor results may have influenced the conclusions from earlier data regarding Negro donors.Transplants into Oriental recipients either from related donors or from Caucasian cadaver donors result in transplant outcomes that are comparable to the outcomes in Caucasian recipients. Most interesting is the comparable survival rate from Caucasian donors into either Caucasian recipients or Oriental recipients, despite a considerable difference in histocompatibility antigen frequencies between these races.Both Caucasian and Negro patients with nephrosclerosis have graft and patient survival rates that are comparable to patients of the same race without nephrosclerosis.The transfusion effect is noted in both Caucasian and Negro recipients. Comparable proportions receive similar numbers of transfusions in each race.

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Seventy-six adult renal allograft recipients were allocated 5 months post-transplantation to daily or alternate day maintenance methylprednisolone therapy. All 15 recipients of living related kidneys and 23 recipients of cadaver kidneys were placed on the alternate day regimen, while 38 patients with cadaveric grafts remained on daily methylprednisolone. In patients on alternate day methylprednisolone, serum creatinine concentrations, frequency of acute rejection episodes, and prevalence of chronic rejection were similar to those of patients on daily steroids. Furthermore, no differences were noted in the rate of loss of graft function between recipients of cadaver kidneys on daily versus alternate day steroids. There were no differences in body weight, blood pressure, degree of hyperglycemia, or hyperlipidemia between patients on the daily or alternate day schedules. However, the prevalence of clinical osteonecrosis and the rate of infectious complications requiring hospitalization were significantly decreased in patients on alternate day methylprednisolone.We conclude that alternate day methylprednisolone therapy is as effective as daily steroids for the maintenance of graft function in renal transplant recipients. The decreased incidence of osteonecrosis and the lower frequency of infectious complications represent a strong argument in favor of alternate day steroid therapy.

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Treatment of rhesus monkey skin allograft recipients with a brief course of rabbit antithymocyte globulin (ATG) produces an enduring immunosuppressive effect on the cellular immune system. Despite early recovery of circulating T cells, in vitro mitogen-induced lympho-proliferative responses of peripheral blood mononuclear cells (PBMCs) remain abnormally depressed for months. In this study we show that depressed mitogen-induced lymphoproliferative responses in these animals are attributable to regulatory effects of adherent PBMCs. Removal of the adherent fraction of PBMCs on Sephadex G-10 produced a significant restoration of the mitogen-induced lymphoproliferative responses in ATG-treated monkeys. Addition of the prostaglandin synthetase inhibitor indomethacin to cultures of unfractionated PBMCs from these animals also caused a significant recovery of the lymphoproliferative response. Indomethacin did not enhance the response of control animals or the response of the nonadherent PBMC fraction of ATG-treated animals. These data suggest that a prostaglandin-dependent mechanism is involved in the suppressive action of the adherent cells. PBMCs from ATG-treated monkeys cocultured with normal cryopreserved autologous cells induced a dose-dependent suppression in the response to both concanavalin A (Con A) and phytohe-magglutinin (PHA). The suppressive activity depended upon the adherent cell fraction and was found to be resistant to low-dose irradiation. These data indicate that administration of rabbit ATG induces nonspecific suppressor cells in the rhesus monkey. Preliminary characterization studies suggest the involvement of suppressor monocytes. The possible role of this suppressor cell system in the immunosuppressive action of rabbit ATG is discussed.

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0041-1337    

出版商:OVID    

年代:1982

数据来源: OVID