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1. |
THE ROLE OF TRANSFORMING GROWTH FACTOR BETA IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1759-1766
Sunjay Jain,
Peter Furness,
Michael Nicholson,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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2. |
STATINS FOR ALL |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1767-1768
Guy Neild,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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3. |
HHV-8: A NEWLY RECOGNIZED PATHOGEN IN TRANSPLANTATION |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1768-1769
N. Regamey,
G. Cathomas,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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4. |
PREFLUSH WITH PLASMINOGEN ACTIVATOR IN NON-HEART-BEATING DONORS: IS IT WORTH IT? |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1769-1771
Robert Porte,
Pierre-Alain Clavien,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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5. |
RENAL TRANSPLANT PROTOCOL BIOPSIES: A SURROGATE BIOMARKER FOR LATE GRAFT LOSS |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1771-1772
Leendert Paul,
Yvo Sijpkens,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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6. |
CHANGING PERSPECTIVES IN PORTAL VEIN THROMBOSIS AND LIVER TRANSPLANTATION |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1772-1774
Neville Jamieson,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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7. |
THE CHALLENGE OF GRAFT-SPECIFIC IMMUNOSUPPRESSION IN XENOTRANSPLANTATION |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1774-1775
A. Dorling,
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ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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8. |
OUTCOME OF KIDNEY TRANSPLANT RECIPIENTS WITH PREVIOUS HUMAN HERPESVIRUS-8 INFECTION1 |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1776-1779
Camille Franc`es,
Catherine Mouquet,
Anne Genevi`eve Marcelin,
St´ephane Barete,
Rachid Agher,
Dominique Charron,
Hadjira Benalia,
Nicolas Dupin,
Jean Charles Piette,
Marc Olivier Bitker,
Vincent Calvez,
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摘要:
Background.The consequences of a prior human herpesvirus-8 (HHV-8) infection in kidney-transplant recipients are still partially unknown. The aim of this monocentric study was to determine the prevalence of HHV-8-seropositive patients at the time of transplantation and to identify the main clinical events of these HHV-8+recipients.Methods.From January 1, 1990 to December 31, 1996, antibodies to HHV-8 latent nuclear antigen were detected by indirect immunofluorescent method in serum samples collected just before kidney transplantation from 400 consecutive patients. Conventional double or triple immunosuppressive treatment was prescribed. For the group of HHV-8+recipients, data including death rate, graft survival, and occurrence of Kaposi’s sarcoma (KS) were retrospectively collected until December 31, 1998. Cofactors associated with KS were studied in univariate and multivariate analyses using a Cox model.Results.Thirty-two patients (8%) had antibodies to HHV-8 in their sera at the time of transplantation. Among these 32, 3 years after transplantation, graft survival was 72%, and KS prevalence was 28% (KS incidence: 8.2/yr/100 HHV-8+recipients). Multivariate analysis identified bacterial and/orPneumocystis cariniiinfection (odds ratio: 8.6;P=0.019) and female gender (odds ratio: 5.34;P=0.047) as factors associated with KS. No KS was observed in patients without anti-HHV-8 antibodies at the time of transplantation.Conclusions.The low graft survival and the high prevalence of KS within the studied population of HHV-8+transplant recipients are strong arguments for systematic screening of HHV-8 serologic features before transplantation, especially in patients of African origin. HHV-8+transplant recipients should be closely monitored to severe infections.
ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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9. |
WARM PREFLUSH WITH STREPTOKINASE IMPROVES MICROVASCULAR PROCUREMENT AND TISSUE INTEGRITY IN LIVER GRAFT RETRIEVAL FROM NON-HEART-BEATING DONORS1 |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1780-1784
Jun-Ichiro Yamauchi,
Sven Richter,
Brigitte Vollmar,
Michael Menger,
Thomas Minor,
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摘要:
Background.Apart fromthe warm ischemic insult, integrity of liver grafts from non-heart-beating donors (NHBD) is additionally affected by microvascular alterations including erythrocyte aggregation and thrombus formation, which might hamper appropriate equilibration of the preservation solution to the grafts’ microvasculature precluding cold preservation. Thus, the objective of our study was to characterize microvascular perfusion quality of University of Wisconsin (UW) solution during initial flushout of livers from NHBD rats, and to analyze the effects of an additional warm preflush with Ringer’s lactated solution (RL) and with RL containing streptokinase (SK).Methods.Cardiocirculatory arrest was induced by phrenotomy. Subsequent to 30 min of warm ischemia, livers were perfused via an aortic catheter by gravity of 100 cm H2O either with 4°C 100 ml UW solution (UW, n=7), or with 25°C 30 ml RL preflush followed by 4°C 100 ml UW solution (RL+UW, n=7), or with 25°C 30 ml SK- (7500 IU) containing RL preflush and 4°C 100 ml UW solution (SK/RL+UW, n=6). Liver microperfusion was quantified using in situ fluorescence epi-illumination microscopy. Liver microcirculation of sham-operated living animals (n=4) served as controls. Enzyme release after a 24-hr cold preservation period was used as an indicator of graft integrity.Results.After 30 min of warm ischemia, microvascular perfusion of UW solution was found markedly altered when compared with that of sham-operated living controls, as indicated by a significant reduction (P<0.05) of acinar and sinusoidal perfusion. Preflush with RL (RL+UW) only slightly attenuated the acinar and sinusoidal perfusion deficits, whereas the addition of SK to RL (SK/RL+UW) resulted in a significant improvement of microvascular graft perfusion (P<0.05). Accordingly, the increased enzyme release observed in solely UW-flushed livers after 24 hr cold preseravtion was only slightly influenced by preflush with RL, but markedly attenuated (P<0.05) by preflush with RL containing SK.Conclusion.The additive fibrinolytic therapy using SK is effective to improve microvascular procurement of livers after warm ischemia and may thus represent a promising approach to attenuate parenchymal cell injury in liver graft retrieval from NHBD.
ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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10. |
LUNG DEFLATION IMPAIRS ALVEOLAR EPITHELIAL FLUID TRANSPORT IN ISCHEMIC RABBIT AND RAT LUNGS1 |
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Transplantation,
Volume 69,
Issue 9,
2000,
Page 1785-1793
Tsutomu Sakuma,
Chiharu Tsukano,
Masanobu Ishigaki,
Yoshihiro Nambu,
Kazuhiro Osanai,
Hirohisa Toga,
Keiji Takahashi,
Nobuo Ohya,
Takayuki Kurihara,
Matomo Nishio,
Michael Matthay,
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摘要:
Background.Because the fluid transport capacity of the alveolar epithelium after lung ischemia with and without lung deflation has not been well studied, we carried out experimental studies to determine the effect of lung deflation on alveolar fluid clearance.Methods.After 1 or 2 hr of ischemia, we measured alveolar fluid clearance using125I-albumin and Evans blue-labeled albumin concentrations in in vivo rabbit lungs in the presence of pulmonary blood flow and in ex vivo rat lungs in the absence of any pulmonary perfusion, respectively.Results.The principal results were: (1) lung deflation decreased alveolar fluid clearance while inflation of the lungs during ischemia preserved alveolar fluid clearance in both in vivo and ex vivo studies; (2) alveolar fluid clearance was normal in the rat lungs inflated with nitrogen (thus, alveolar gas composition did not affect alveolar fluid clearance); (3) amiloride-dependent alveolar fluid clearance was preserved when the lungs were inflated during ischemia; (4) terbutaline-simulated alveolar fluid clearance was preserved in the hypoxic rat lungs inflated with nitrogen; (5) lecithinized superoxide dismutase, a scavenger of superoxide anion, and N&ohgr;-nitro-l-arginine methyl ester, an inhibitor of nitric oxide, preserved normal alveolar fluid clearance in the deflated rat lungs.Conclusion.Lung deflation decreases alveolar fluid clearance by superoxide anion- and nitric oxide-dependent mechanisms.
ISSN:0041-1337
出版商:OVID
年代:2000
数据来源: OVID
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