摘要:

AbstractFetal palate morphogenesis was studied in normal and hydrocortisone‐treated hamsters. Formation of the normal palate was completed between day 12:00 and 13:00 of gestation, and during this period 8 distinct developmental stages were recognized. Following hydrocortisone administration the early stages, during which vertical‐to‐horizontal shelf reorientation occurs, appeared to be unaffected, but subsequent fusion between opposing shelves was inhibited. Both chronological age and fetal weight provided reliable criteria for stages of normal palatal development. Following hydrocortisone administration, however, fetal weight was a poorer indicator of stage of palate organogenesis than chronologica

ISSN:0040-3709    

DOI:10.1002/tera.1420130112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractChicken eggs of 4 or 6 days of incubation were injected with 10 μg 6‐aminonicotinamide (6‐AN) or 6‐AN plus various doses of sodium ascorbate, calcium ascorbate, or ascorbic acid; 11‐day embryos were examined grossly and histologically. 6‐AN‐treated embryos had various degrees of micromelia and were reduced in overall size. All three ascorbates inhibited 6‐AN teratogenesis but not completely. The extent of inhibition was dose related. Increased amounts of intercellular matrix and decreased necrosis of chondrocytes in the limb cartilage of protected embryos correlated with the

ISSN:0040-3709    

DOI:10.1002/tera.1420130113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe teratogen 2‐amino‐l,3,4‐thiadiazole (ATDA) is an antagonist of nicotinamide, and may act by interfering with the synthesis or utilization of the coenzyme nicotinamide adenine dinucleotide (NAD). Several compounds that can be converted to NAD were tested as antiteratogens against ATDA. At day 11 of gestation (sperm day = day 0) pregnant Wistar‐derived rats were given single ip injections of ATDA (100 mg/kg), or ATDA immediately followed by the suspected antiteratogen ip or by gavage, or the antiteratogen alone. Compounds tested were NAD, nicotinamide, nicotinic acid, quinolinic acid, kynurenine sulfate, and L‐tryptophan, in doses of 10–200 mg per animal. At autopsy (day 20) fetuses were recovered and examined. It was found that each antiteratogen significantly reduced the frequency of ATDA‐induced resorptions and malformations. At certain doses each antiteratogen gave complete protection against ATDA‐induced malformations in some, but not all, litters. These results support the hypothesis that ADTA interferes with the synthesis or utilization of NAD and suggest that substances converted to NAD act as antiteratoge

ISSN:0040-3709    

DOI:10.1002/tera.1420130114

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130115

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130116

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130118

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130119

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY