摘要:

AbstractIncreased fetal mortality and congenital malformation were induced in mice by Ca‐DTPA, a chelate widely used for the removal of internally deposited plutonium in human beings. Mated C57BL/Do female mice were given five daily injections of 720–2,880 μmol/kg Ca‐DTPA during early, mid, or late gestation. Damage probably occurred as a result of the depletion by Ca‐DTPA of zinc and manganese, trace elements essential to growth and development. By extension, it seems likely that Ca‐DTPA could damage human fetuses. A much safer chelate, Zn‐DTPA, is recommended for the treatment of accidental plutonium c

ISSN:0040-3709    

DOI:10.1002/tera.1420140202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractHistological and anthropometric studies were made of the hands and face of a 17‐week‐old (postmenstrual) human fetus that was exposed to warfarin throughout gestation. The fetus had marked nasal hypoplasia and the facial cartilages contained discrete foci of abnormal cartilage. When compared with agematched control fetuses hand pattern profile analysis showed that the brachydactyly was due to shortening of the terminal phalanges. Histologically chondrogenesis was disordered in the carpals and phalanges, with the most deviant development occurring at the distal ends of the terminal phalanges. In none of the areas of abnormal cartilage was there evidence of hemorrhage or hemosiderin deposition. It is our contention that warfarin is teratogenic in human beings and that its teratogenicity is not due to focal hemorrh

ISSN:0040-3709    

DOI:10.1002/tera.1420140203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractRats were mated for two or 15 hours and variability of day‐12 embryos in weight, protein content, and [3H]thymidine incorporation was compared in the long mating period (LMP) and short mating period (SMP) groups by a 2‐level nested analysis of variance. Variability in day‐20 fetal weight was similarly compared. In both groups day‐12 embryonic weight was relatively more variable than day‐20 fetal weight, and variability was less in SMP than LMP animals for each comparison made, although statistical significance was attained only for thymidine incorporation. “Litter effects” were noted but not of the magnitude reported by other investigators. It was concluded that inappropriate statistical methods have encouraged the belief that among‐litter variability usually exceeds within‐litter fetal weight variability. The teratological implications of reduced developmental variability and the “litter ef

ISSN:0040-3709    

DOI:10.1002/tera.1420140204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe epidemiological characteristics are presented of 46 children with small‐bowel atresia, ascertained over a 6‐year period by an active, population‐based birth defect surveillance program in Atlanta, Georgia. The malformation occurred at a rate of 2.7/10,000 livebirths. The previously reported association of duodenal atresia and Down syndrome was confirmed. No instances of familial association were noted, nor was any excessive prenatal exposure to drugs found. Thirty‐two instances of isolated small‐bowel atresia were analyzed in detail. The frequency of the isolated defect for blacks was twice that for whites because of a higher rate for black females. The isolated defect was commonest in the winter months. The relation between isolated small‐bowel atresia, birth weight, and mortality was discussed. This small series cannot readily be subdivided into distinct epidemiological groups on the basis of the location of the atretic lesions along the length of the

ISSN:0040-3709    

DOI:10.1002/tera.1420140205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractA systematic gross and microscopic study of the placenta was done on human spontaneous abortions, correlating placental morphology and karyotype of the conceptus. Consistent abnormalities were seen in the four major forms of human heteroploidy, so that a fairly accurate “karyotypic diagnosis” could be made from careful gross and microscopic examination of the aborted material. Depressed growth activity and dysmorphogenesis characterized these placentas, reflecting placental participation in the disturbed phenotypic expression of heteroplo

ISSN:0040-3709    

DOI:10.1002/tera.1420140206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractTo examine the hypothesis that the teratogenic effects of the phenothiazine derivative T‐82 are due to its causing a riboflavin deficiency day 11 or 12 pregnant CB Wistar rats were each given 2,000 mg/kg T‐82 po plus 100 mg/kg riboflavin ip, 12.4 mg/kg ATP ip, or both. The rates of fetal mortality and external malformations were significantly decreased in all supplementation experiments. The frequencies of cleft palate, micrognathia, and micromelia were unchanged but those of ectopic testis and hydrops fetalis were significantly increased in the group treated with T‐82 and ATP on d

ISSN:0040-3709    

DOI:10.1002/tera.1420140207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractOral administration of high dosages of the dithiocarbamate pesticides maneb and mancozeb was teratogenic in rats but not in mice. The malformations, severe limb and craniofacial defects, were pronounced after maneb treatment but less so after mancozeb and propineb, zinc‐containing compounds. The teratogenic effect of maneb was progressively reduced by simultaneously adminstering increasing amounts of zinc acetate. The mechanism of the teratogenic effect may involve the compounds being chelating agents, trapping zinc required for many important enzyme system

ISSN:0040-3709    

DOI:10.1002/tera.1420140208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe clinical and genetic findings in 214 patients with sagittal synostosis are described. Seventy‐three per cent of the patients were male. Children with sagittal synostosis were treated earlier than those with coronal synostosis. Major malformations occurred in 22%, and 8.9% were mentally retarded. The retardation was clearly unrelated to the synostosis in almost half the patients. The remaining retarded patients had a significantly lower mean birth weight, higher frequency of malformations, and later age at operation than the control group. We believe the late age at operation was due to bias in the ascertainment of this group of retarded children, and that sagittal synostosis was simply one of a number of malformations that can occur in children with intrinsic retardation. Familial data and the skull measurements of a sample of parents of affected children were compatible with multifactorial inheritance; however there is need for prospective family studies and parental measurements on ethnically uniform group

ISSN:0040-3709    

DOI:10.1002/tera.1420140209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractA stillborn male infant with cyclopia, holoprosencephaly, extracephalic malformations, and trisomy 18 is described. The importance of chromosome studies in infants with severe congenital malformations is discussed.

ISSN:0040-3709    

DOI:10.1002/tera.1420140210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420140211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY