ISSN:0040-3709    

DOI:10.1002/tera.1420130218

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130219

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractDevelopment of the arterial vasculature in the secondary palate was studied in Sprague‐Dawley rat fetuses treated with vitamin A plus cortisone, 6‐aminonicotinamide (6‐AN), and X‐rays. Most of the control and teratogen‐treated fetuses were India‐ink injected for study of the palatine vasculature; others were histologically sectioned in the coronal plane. All 3 teratogens affected development of the lateral palatine processes and arterial vasculature. Vitamin A plus cortisone produced severe palate deformities. The palatine processes were composed of multiple horizontal and vertical processes containing abnormal epithelial and cartilaginous components. The palatine arteries remained widely separated in the maxillary area of the palate but narrowed to form a “V” pattern in the premaxillary area. 6‐AN and X‐rays delayed development of arterial patterns and the palatine processes, and decreased growth of the lateral palatine processes. After reorientation the palatine arteries remained fairly widely separated in fetuse

ISSN:0040-3709    

DOI:10.1002/tera.1420130202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractPhytohemagglutinin (PHA)‐stimulated lymphocyte cultures of a healthy human donor, treated in vitro with 0.5, 1.0, and 1.5 mg LiCl/10 ml of culture (equivalent to 1.1, 1.5, and 2.1 mEq/l, respectively) had an increased incidence of chromosomal anomalies and a significant increase in satellite associations, compared with an unexposed culture. The in vivo effects of Li2CO3on the chromosomes of psychiatric patients on lithium therapy showed increased chromosomal abnormalities, as compared with lithium‐free controls. A significant finding was a marked increase in satellite associations in all lithium‐treated patients. The mitotic index of PHA‐stimulated human lymphocytes exposed to doses of lithium salts (0.5–1.5 mg/10 ml of culture media) was decreased, as measured by [3H]thymidine incorporation i

ISSN:0040-3709    

DOI:10.1002/tera.1420130203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractHydrocortisone acetate (1–10 mg/egg), when injected into the extraembryonic celom of 3‐ or 4‐day chicken embryos, caused necrosis in limb‐bud mesoderm after further incubation for 24 h. The necrotic areas usually appeared in the central and subapical mesoderm. Similar treatment of 4‐day embryos with a higher dose (7.5 mg/egg) caused, in addition, hemorrhage in limb buds, micromelia, and slight growth retardation. The mechanism of the resulting necrosis and phagocytosis are

ISSN:0040-3709    

DOI:10.1002/tera.1420130204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe teratogenic effects on the offspring of ferrets given single sc injections of mustine hydrochloride on various days of gestation is described and compared with a smaller series of rats treated at similar stages of embryonic development. Distinct qualitative differences in the teratogenic responses of the 2 species were demonstrated. The predominant defects in ferrets were anophthalmia produced during early gastrulation, and tail abnormalities produced at the head‐process stage; whereas in rats the major deformities were limb defects and cleft palate and these resulted from treatment at the stage of the paddleshaped forelimb. The advantages of the ferret as an additional species for teratogenicity studies is discussed and methods of providing a continuously breeding colony required for such studies are describe

ISSN:0040-3709    

DOI:10.1002/tera.1420130205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractTwo half‐cousins with a complex of malformations including unilateral lower amelia and oligosyndactyly of the hands are described. The differential diagnosis of the syndrome is presented. It is possible that it is inherited as an autosomal dominant with incomplete penetranc

ISSN:0040-3709    

DOI:10.1002/tera.1420130206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractXenopus laevis embryos were exposed to hydrazine and its methylated derivatives, (mono)methylhydrazine, 1,2‐dimethylhydrazine (SDMH), and 1,1‐dimethylhydrazine (UDMH). Concentrations of hydrazine, methylhydrazine, and UDMH in excess of 10 mg/1 were teratogenic; SDMH was teratogenic at concentrations of 50 mg/1 or greater. Exposure to lower concentrations permitted survival and development into normal larvae. The period of embryogenesis during which exposure to hydrazine was teratogenic was during neurulation. Exposure to these compounds at later or earlier periods affected viability but was not teratogenic. The malformations affected the head, trunk, and tail. The most common abnormality observed was tail kinks. Other abnormalities were microcephaly, cyclopia, shortening of the trunk, and edema. All malformed embryos also had abnormal notochords. The possible relation of notochordal abnormality to the pathogenesis of other malformations is discus

ISSN:0040-3709    

DOI:10.1002/tera.1420130207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractPregnant and lactating hamsters were inoculated with reovirus type 3 and H‐1 virus to determine whether they had any special susceptibility as compared with nonpregnant controls; whole blood, liver, and uterus were tested for virus on successive days after inoculation. Results showed that both agents proliferated to highest titers in pregnant as well as in lactating animals. These results were most striking with reovirus, which propagated to only a limited extent in controls and hamsters in the first half of gestation, although developing to high titers in the second half. A feature of the experiments was the ability of both agents to infect the postpartum uterus. Uterine infections, which appear to have importance for both rubella and cytomegaloviruses, should it would seem, be considered in relation to any viruses capable of inducing fetal infections or congenital anomalie

ISSN:0040-3709    

DOI:10.1002/tera.1420130208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

ISSN:0040-3709    

DOI:10.1002/tera.1420130209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY