ISSN:0040-3709    

DOI:10.1002/tera.1420100202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractTwo cases of cervical teratoma and two of “complex cyst of the thyroid” are presented with special reference to (i) association with the thyroid gland, (ii) age of presentation, and (iii) differences between hamartomas and teratomas. The authors propose, from clinical and embryological evidence, that anterior neck teratomas arise from the thyroid gland and that failure of organogenesis at an early prenatal stage is involved. These teratomas probably arise from totipotential cells of each of the three germ cell layers found in the thyroid gl

ISSN:0040-3709    

DOI:10.1002/tera.1420100203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractA female fetus of 63 mm crown‐rump length was examined. Aplasia of the left radius and thumb, preaxial polydactyly of the left foot, rib and vertebral fusions on the left side, right aortic arch, a small membranous ventricular septal defect, and a single umbilical artery were detected. The potential counseling value of detailed examination of small fetal specimens is stresse

ISSN:0040-3709    

DOI:10.1002/tera.1420100204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractBy means of introductory correspondence and telephone interviews a survey was made of the current potato consumption habits of 265 mothers of infants born with neural‐tube malformations during January 1970 to December 1972, and of 549 matched control mothers. Both the cases and the controls were obtained from the same single source—birth certificates. Renwick's hypothesis was tested by subjecting the responses to seven questions to a modified χ2test. The results did not support the hypothesis. In all seven instances the direction of the responses was opposite to that predi

ISSN:0040-3709    

DOI:10.1002/tera.1420100205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractIn a study of 54 dogs with ectopic ureter from a large clinic‐hospital population four breeds with high risk for the defect were identified (Siberian Husky, West Highland White Terrier, Fox Terrier, Miniature and Toy Poodle). Some epidemiologic features of this anomaly in dogs were similar to those in man. The breeds with excess risk may serve as models for genetic studie

ISSN:0040-3709    

DOI:10.1002/tera.1420100206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractFission‐spectrum neutrons from the Janus reactor at Argonne National Laboratory were compared with γ‐rays in terms of their relative biological effectiveness (RBE) for embryolethal and teratogenic effects in mice. No evidence was found of any processes that were abnormally sensitive to neutrons. The RBE for killing embryos and producing abnormal embryos or specific abnormalities was between 2 and 3. This is close to the values found in other systems for processes involving cell kil

ISSN:0040-3709    

DOI:10.1002/tera.1420100207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractColony‐bred ICR‐JCL female mice were subjected to physical training by imposing a daily routine of running 6 days a week for 4 weeks from the 6th‐9th weeks of age. These and nontrained females were mated and some from both groups were forced to exercise (running for 30 min/day) on the 9th‐16th days of gestation. Pregnant mice were killed on the 19th day of gestation. The fetuses of females exercised during midpregnancy showed increased mortality, slight decrease in body weight, and some delayed ossification, but no malformations. Training before pregnancy was effective in decreasing the fetal mortality in the females exercised during midpr

ISSN:0040-3709    

DOI:10.1002/tera.1420100208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractThe uterine‐muscle relaxant isoxsuprine hydrochloride was administered to pregnant Wistar rats 30 min before amniotic‐sac puncture on day 15 of gestation. The frequency of hemorrhages in fetuses, especially in the interdigital area of footplates, was examined 1–2 h after puncture. The frequency of hemorrhages (31%) was significantly lower (P<.001) than in fetuses not exposed to the muscle relaxant (59%), probably indicating a positive role of uterine muscular contraction in inducing hemorrhages, which were previously reported to lead to limb malforma

ISSN:0040-3709    

DOI:10.1002/tera.1420100209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractAlthough the embryopathic effects of caffeine have been established in various mammals little is known about the mechanisms involved. Speculating that caffeine teratogenicity may be linked to catecholamine release induced by this compound we attempted a prophylactic type of experiment against caffeine teratogenicity in mice by maternal pretreatment with propranolol, a β‐adrenergic‐blocking agent. Pregnant mice on day 13 of gestation were each given a single iv injection of 2.5, 5. or 10 mg/kg propranolol and five minutes later a single ip injection of 200 mg/kg caffeine. The controls received saline or either of the drugs alone. Fetuses were examined for abnormalities on day 19 of gestation. The fetoputhic effects of caffeine were significantly reduced by pretreatment with propranolol at all dosages; and it was therefore hypothesized that the β‐adrenergic actions of catecholamines caused to be released by caffeine induce fetal circulatory disturbance, which leads to fetal abnorm

ISSN:0040-3709    

DOI:10.1002/tera.1420100210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY

摘要:

AbstractPregnant Wistar rats were each injected once ip with various doses of sodium arsenate at one of days 7–12 of gestation (sperm day = day 0). The embryolethal and teratogenic effects of arsenate were dose dependent. The optimum dose, 30 mg/kg, produced optimal effects when injected at day 8, 9, or 10. At autopsy (day 20) the four most frequently seen soft‐tissue malformations were eye defects (anophthalmia and microphthalmia), exencephaly, renal agenesis, and gonadal agenesis. Ribs and vertebrae were the skeletal elements most susceptible to arsenate treatment. The atlas bones were rudimentary or missing in 63% of the experimental fetuses examined for skeletal defects. The results are compared and contrasted with those previously reported following arsenate treatment in hamsters and m

ISSN:0040-3709    

DOI:10.1002/tera.1420100211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1974

数据来源: WILEY