ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Epidemiological studies have strengthened the case for Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 being the long-sought Kaposi sarcoma agent, but have also pointed to a role for other co-factors. Like other tumour viruses, Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 establishes a latent (persistent) infection in Kaposi sarcoma-spindle (tumorous) cells, but can also undergo lytic replication in these and other cell types. Several latent and lytic viral genes may play a role in the pathogenesis of Kaposi's sarcoma. Although Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 contains at least two genes with transforming properties, it has not yet been shown to be oncogenic in animals. This, and other studies on inflammatory/angiogenic cellular and viral cytokines as well as HIV-Tat, emphasizes the multifactorial complexity of the pathogenesis of Kaposi's sarcoma.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Recent developments in leishmanial research include better survey procedures to determine risk factors in the community. Community-based scabies control is seen as the only way to reduce the morbidity caused by this infection in developing countries. The diagnosis of both infections, and of head lice, however, continues to provide problems for the physician.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Fungal infections of the skin, hair and nails are among the most common skin diseases. The increased incidence of these infections in recent years has been attributed to the large number of immunocompromised patients, life-style changes (greater attendance at gymnasiums, public baths, etc.), the use of chemotherapeutic agents, and the greater presence of elderly people in the general population. Superficial fungal infections were also the most frequent and troublesome dermatological condition occurring among US forces during the war in Vietnam.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

The incidence of necrotizing fasciitis has increased in the past decade as a result of the resurgence severe group A streptococcal infection. Mortality has remained unchanged over the past 60 years, supporting the notion that immune modulators, such as intravenous immunoglobulin, are required to alter the physiological process during the early stages of infection.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

The data from the most recent studies concerning infection with human herpes virus 8 strongly support a pathogenic role for this virus in the tumoral hyperplasia which is a feature of Kaposi's sarcoma. The results from the first studies of the sensitivity of human herpes virus 8 to antiviral drugs were also published last year. This review also concerns bacterial and mycobacterial infections showing unusual presentation, important trials in the prevention of infectionwith varicella zoster virus by using vaccination in children with leukemia, and a controlled therapeutic study in HIV-infected patients presenting with early syphilis.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Polymerase chain reaction protocols are now available for the diagnosis of all of the major bacterial respiratory tract pathogens. Molecular techniques are also being used to determine the susceptibility ofStreptococcus pneumoniaeandMycobacterium tuberculosis. In addition, polymerase chain reaction-based diagnosis will find a place in the investigation of the epidemiology of some pathogens such asBordetella pertussisandChlamydia pneumoniae. The added sensitivity will allow the detection of mild or asymptomatic cases or carriers who may play a role in sustaining the pathogen in the community.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Antibiotic resistance in respiratory pathogens has dramatically increased during recent years. Resistance to penicillin and multiple antimicrobial agents in pneumococci and resistance to ampicillin inMoraxella catarrhalisandHaemophilus influenzae, as a result of betalactamase production, have become highly prevalent worldwide. The emergence of multiple drug-resistant tuberculosis in different countries is of concern, and has become a therapeutic challenge.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Efforts to reduce hospitalization or the length of stay are common topics in papers published last year.Chlamydia pneumoniaeis now recognized worldwide as a common pathogen in community-acquired pneumonia. A great variation in the frequency of various pathogens is found in different countries, stressing the importance of ascertaining the aetiological and epidemiological situation in each respective country.

ISSN:0951-7375    

出版商:OVID    

年代:1998

数据来源: OVID