ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02480.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.The use of a gelatin plasma substitute as an integral part of a unified national program for the procurement of blood components and derivatives paves the way for the extensive use of red cell concentrates in the treatment of hemorrhage, the plasma from the original donations being partly diverted to the fractionation program of a national transfusion service. We estimated the potential of such a system paced by the demand for red cells and predicted that the use of 20% of fresh whole blood and 80% concentrates would not increase the demand for albumin, the yield of which would suffice to cover three‐quarters of current needs in our country. The actual performance of a program using 85% of red cell concentrates in a university hospital with an exceptionally high incidence of major hemorrhage was analyzed in detail. The use of albumin per unit of transfused red cells rose by 9%. With a nationwide increase of this magnitude, 67% of the demand in our country could still be met and the estimated true need for albumin of 200 kg per million inhabitants and year would be fully covered. The yield of factor VIII is 200–300% of the demand. The determinants of the effects of such a system vary from country to country, but its fundamental potential is obviously considera

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02481.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) a

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02482.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.Filter columns (Imugard® filters) packed with cotton wool prepared fromGossypium barbadensecotton removed 95–100% of leukocytes from packed red cell suspensions. Recovery of red cells was about 95%. The efficacy was similar for ACD and heparinized blood. Blood was filtered below 10°C within 30 min under pressures of less than 0.2 kg/cm2. The shape and functions of the red cells were not altered by filtration. No pyrogenic or toxic substances, and little particulate matter were eluted from the filt

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02483.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.Blood drawn into CPD solution from 33 normal donors was divided into four groups: (I) centrifuged (at 5,000 g for 7 min) after 7 days of storage, (II) centrifuged after 14 days storage, (III) centrifuged after 21 days storage and (IV) uncentrifuged. After 21 days of storage, aliquots of all units were labeled with chromium‐51, reinjected into the donor from which they were drawn and erythrocyte survival was measured. Red blood cell recovery and survival for all four groups was essentially the same; 24‐hour recovery was 85%; TVi was 28.2–31.6 days. Our results suggest that blood can be centrifuged and stored at any time during its 21‐day shelf life without detrimental effect on erythrocyte s

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02484.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.A modified electrophoretic system for the determination of C4 polymorphism has been found with which the new allotype F1 could be detected. The system has been applied to the population distribution of C4 in 266 unrelated Germans, further to association and linkage studies. Gene frequency was 0.3985 for C4F, 0.5526 for C4Sand 0.0489 for the rare C4 genes. In the population sample, significant association between Bf and C4 but no indication for close association between C4 and GLO I has been found. In the families HLA, Bf and C4 segregated together.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02485.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Abstract.An antibody is described which defines a new high frequency red cell antigen, Duclos, whose expression seems to require the presence of both U and Rh fundamental antigens. Apart from the antibody maker's own red cells the only nonreactive samples were from RhnullU impaired individuals, one example of which was shown however to yield very slight amounts of antibody through absorption‐elution tests. RhmodU weak cells gave very depressed and RhnullU positive or Rh common U negative cells moderately depressed reactions. The proposita's red cells had an apparently normal Rh‐LW condition but their U antigen was significantly decreased. No further Duclos negative individual was found by screening 8,500 blood donors in the Paris a

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02486.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02487.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1978.tb02490.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY