摘要:

Summary.A total of 973 unrelated Danes and Norwegians have been typed for a number of HL‐A iso‐antigens, and so have 150 Danish and Norwegian families with a total of 480 children. Two series of HL‐A iso‐antigens were investigated: the LA series with the antigens HL‐Al, 2, 3, Ba*, ILN*and LA4, and the Four series with the antigens HL‐A5, 7, 8, T12, R*, HN, FJH and BB. These antigens were inherited as co‐dominant characters with the exception of Ba*, ILN*, and R*, which were operationally recessive to HL‐A2, 3 and 5, respectively, but co‐dominant in respect of the other factors. No individuals carried more than two antigens from each series, and the family analysis yielded no evidence against the assumption that the antigens within each series are controlled by mutually exclusive genetic determinants: The LA and Four series represent two mutational sites within the HL‐A chromosomal region. No recombinations between these series were observed in this study, and the estimated upper limit of the recombination frequency between the corresponding sites was 0.84%. A total of 345 parental haplotypes could be unequivocally deduced; two of these, HL‐A (1, 8) and HL‐A (3, 7), occurred much oftener than should have been expected from the frequencies of the corresponding determinants, and there is thus linkage disequilibrium between

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01438.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Summary.By immunization within specially selected donor‐recipient pairs it was possible to produce antibodies against three new HL‐A antigens. One of these was later found identical to Dn17, the other two are called Li of the LA series, and LND of the Four series of antigens. The antigens behaved in population and family studies as if they were determined by alleles at the LA and Four nib‐loci. The present status of the HL‐A system seems to be that 8 La alleles and 9 Four alleles are well defined. However, unknown HL‐A antigens of low frequency still remain to be identified. The reported method seems to he very useful for thi

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01439.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Summary.Human milk has been found to contain a high concentration of water‐soluble I blood‐group substance. Tests with 24 different anti‐I sera showed that to a variable extent all of them could be inhibited by milk and some could be inhibited by strong I secretor saliva. The susceptibility of I antibodies to inhibition was not related to titer, and the results suggest that qualitative differences in the antibody‐antigen reaction are resp

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01440.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Summary.Sera from 170 persons were tested for the presence of an anti‐steroid factor/s in their globulin fraction by passive haemagglutination method, using as antigen a conjugate, of hydrocortisone hemisuccinate coupled to rabbit serum albumin. About 26% of sera from normal adults were found to contain titers of at least 1/25 in their globulin fraction. With respect to presence of the factor, there was no significant difference between normal subjects and those that had undergone one or more cardiac infarctions. 80% of syphilitic and 100% of rheumatoid arthritis patients showed presence of the factor in their sera. It was almost entirely absent in sera of children 6 months to 3 years of age. The specificity of the factor for steroids was demonstrated by the inhibition of haemagglutination, carried out with hydrocortisone hemisuccinate or sodium cholate. By its sensitivity to mercapto‐ethanol, its heat lability and its failure to give PCA response, this factor is most likely an

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01441.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Summary.The studies reported here indicate that the sheep red blood cell surface can be modified with poly‐L‐lysyl gelatin, and such changes can be monitored by the technique of microelectrophoresis. When these cells are injected into mice, enhanced levels of hemolytic antibody are obtained over control unmodified cells for the primary, early, and late secondary responses. Although the experiments were designed primarily to demonstrate the phenomena, rather then to determine the mechanism, it seems unlikely that the enhancement is due to physical modification of the anti

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01442.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01443.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01444.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01445.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01446.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01447.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY