摘要:

Abstract.In a series of MNSs tests on 3,895 Swiss blood donors, in which use was made of the dosage effect of anti‐M and anti‐N sera for distinguishing rare heterozygotes within groups M and N, 19 phenotypes were recognized. Ten of these were rare, involving only 15 persons, and the corresponding genotypes were ascertained. The frequencies of the alleles thus recognized at theMNand theSslocus were obtained by counting. The number of possible combinations of these ‘single genes’ to gene complexes is 15, and 10 of them occurred in the series. The frequencies of these complexes were estimated by computer. The genotype proportions expected from the gene and gene complex frequencies were shown to agree closely with the observed proportions. The possibility that, owing to the special methods employed, certain very rare genotypes escaped detection is di

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01476.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Because of an apparent exclusion of paternity of the type father M/child N, and of the father's insistent denial of this exclusion, a thorough investigation of the MNSs groups of a Chinese family was carried out. The ‘exclusion’ was proved false by the demonstration ofMkin the persons involved. It is the first time that this rare gene comes to notice through disputed paternity, and this is the first example of Mkin Chinese. The family also had several members possessingMsIII, a gene complex which produces M, s, and the antigens characteristic of Cell Class III in the Miltenberger sub‐system. Three sibs of the propo situs had the very rare genotypeMsIII/Mk.The medico‐legal and serological aspects of the case adi

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01477.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.A naturally‐occurring anti‐Mvwas identified. The family of the Mvpropositus was studied and shown to contain another variant of the MNSs blood group system. A weak N antigen was associated with a reaction with anti‐Hil, part of the Miltenberger complex. A new class (V) was revealed which is Vw(‐) Mi(a‐) Mur(

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01478.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.The serum of healthy Mrs. Ste. whose blood group is A1B agglutinated the erythrocytes of some 50% of B persons tested. No other erythrocytes were agglutinated. The agglutinin was absorbed by group B and AB erythrocytes, slightly weaker by A1erythrocytes and still more weakly by A2and O erythrocytes. The specificity of the agglutinin thus resembles that of freshly harvestedBandeiraea simplicifolialectin. The relationship between the agglutinin and her self‐tolerance was discusse

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01479.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Random Dutch donors were typed for Gm markers of γ1, γ2 and γ3 heavy chains. The relatives of individuals with uncommon phenotypes were collected and typed. The uncommon gene complexes, deducted from the pedigrees, were classified into several groups according to their possible generation. It was concluded that multiple genetic events, notably recombination, although rare, occur in γ subclass cistr

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01480.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Investigations of the sera from group O and A patients with haemophilia‐A and ‐B, and with von Willebrand's disease, revealed that immune antibodies anti‐A and anti‐B can be stimulated alter treatment with cryoprecipitate and factor IX concentrate (PPSB). The group O sera were investigated only for immune anti‐A. The immune properties demonstrated in the sera consisted in an increase in the titre of saline agglutinins and the appearance or increase of incomplete and haemolytic antibodies anti‐A or anti‐B. The stimulation of immune antibodies anti‐A and anti‐B is most probably caused by the presence of soluble A and B blood group substances in the products, as A substance could be demonstrated in samples of cryopre

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01481.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.Dental extractions were performed in five patients with Christmas disease, whilst giving infusions of a concentrate which contained three other clotting factors in addition to factor IX. The therapy was supported locally by inserting a plate over the extraction area, which was removed for cleaning on the third and subsequent days for a short period. The concentrate was extremely well tolerated. There was little or no bleeding following extraction, and several extractions of wisdom teeth were carried out without loss of blood. In order to obtain the required level of factor IX in the plasma at a minimum of 10% after the first infusion and before the extractions, a quantity of the concentrate had to be given which was equivalent to at least two units of factor IX per kg of body weight. A higher level of factor IX was sometimes required in the days following the extractions.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01482.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.A patient is described who produced antibodies during a period of bone marrow failure produced by prolonged administration of busulfan for chronic myelogenous leukemia, The patient produced antibodies to transfused blood constituents including serum IgA, leukocytes and platelets after minimal stimulus. This case illustrates that under certain conditions the so‐called immunosuppressive agents can cause a paradoxical heightening of antibody respons

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01483.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Abstract.A technique is described which allows quantitation of antigens in the nanogram range using a simple radioimmuno‐inhibition assay. All the reactants can be prepared in large batches in one day and are stable for months. The test is highly reproducible over periods of months and correlates closely with the thousand‐fold less sensitive Mancini techni

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01484.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1970.tb01485.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY