摘要:

Abstract.The factors of donor selection, corticosteroid drug choice, dose, timing and route of administration were studied to optimize granulocyte yield employing the Haemonetics Model 30 Blood Processor. Our data suggest that donors giving one excellent yield do not necessarily do so again. Donors with high initial granulocyte counts had only marginal increases in counts after taking corticosteroids. Selecting donors on the basis of high previous yield or granulocyte count is not a feasible strategy for improving granulocyte yields. Highest yields of granulocytes (16times1o9total; 4.1times109/liter processed) were obtained with any of four split‐dose corticosteroid regimen. This increment is almost twice as large as the previously reported improvement using continuous‐flow centrifugation. The choice of steroid, the route of administration and the timing of the split doses are not criti

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00749.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.As determined in rabbits, the in vivo plasma survival, i.e. half‐life (t 1/2), of albumin produced by the cold‐ethanol procedure did not differ significantly from that of native albumin (p>0.5). Plasma survivals of reprocessed and heat‐ethanol produced albumins were significantly less than that of the native protein (0.02

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00750.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.295 lepromatous and 74 tuberculoid leprosy patients were typed for HLA‐A, ‐B and ‐C and compared to 110 healthy controls. It was found that frequency of HLA‐B7 was significantly high and that of Bw54 was significantly low in lepromatous leprosy. HLA‐DR and MT types were investigated in 84 lepromatous and 28 tuberculoid patients and compared to 55 controls. Both lepromatous and tuberculoid patients showed a marked increase in DR2 frequency. The relative risk is 8.7 and 5.9. Lepromatous leprosy showed an increase in frequency of MT1 and decreases in those of DRw9 an

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00751.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.IgG class and subclass levels were measured in the sera of malaria‐infected patients who had high serum antibody titres (≥ 1 in 5,120) as well as in uninfected controls with low serum malaria antibody titres (<1 in 320). The malaria‐infected patients had higher IgG and IgGI subclass levels than the uninfected controls (p<0.005). There was a slight diminution in the mean IgG3 concentration in the malaria‐infected p

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00752.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.Nea, a red cell antigen present in 6% of Finnish people but in less than 1% of other Europeans tested, is shown to be part of the LW system. Tests on 10,025 Finnish donors show the antithetical relationship of anti‐Nea(proposed name anti‐LWb) and anti‐LW made by LW3people (proposed name anti‐LWa). Tests on families of previously reported LW3propositi and of LW(a‐b+) Finnish donors support the hypothesis thatNea(L Wb)is an allele at theL Wlocus which when homozygous produces the phenotype once c

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00753.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.Low frequency antigens of the MNSs system were tested for sensitivity to trypsin treatment which subdivided them into two distinct groups. A new interpretation of the Miltenberger complex based on determinants rather than type sera is proposed.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00754.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.The abnormal erythrocyte of the McLeod phenotype displays a reduced Kell blood group expression, an abnormal morphology in about 30% of the total red blood cell population and a decrease in water permeability. These parameters have previously been shown to be independent of membrane lipid composition, microviscosity and electrolyte transport. Findings such as these seem to implicate the involvement of a defective membrane protein. The present study investigated membrane composition by utilizing two techniques: freeze‐fracture electron microscopy and discontinuous polyacrylamide gel electrophoresis. Electrophoretic scans revealed no apparent band additions or deletions showing McLeod membrane protein composition to be normal. Freeze‐fracture electron microscopy did show a significant increase in intramembrane particle density. These findings may be resolved by proposing a dissociation of the band 3 glycoprotein. Unlinkage of this polypeptide, thought to be involved in water transport and intramembranous particle composition, could account for the decreased water transport and increased particle density seen in the McLeod erythrocyte membr

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00755.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract.A case of chronic cold haemagglutinin disease due to an IgM monoclonal (kappa) autoantibody with anti‐M‐like specificity is described in a patient with the MN phenotype. The autoantibody was present in very high titre and active at body temperature, but haemolysis was only mild. The direct antiglobulin test was positive due to C3d on the patient's red cells, and the autoantibody was able to bind complement to normal MM and MN cells with a marked dosage eff

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00756.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00758.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Book reviewed in this article:S. J. Baum, G. D. Ledney, A. Khan, Experimental Hematology Today 1981H. G. Sieberth, Plasma Exchange

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1982.tb00759.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY