摘要:

Abstract.A 25‐year‐old man with rapidly progressive glomerulonephritis developed an autoantibody with anti‐M specificity following haemodialysis and renal transplantation. The patient's red cells typed as MN. The antibody was an IgM globulin which displayed marked dosage effect and variable pH dependence. The thermal range of reactivity extended to 37°C. The stimulus for the production of the antibody is unc

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04495.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Three examples of an antibody which detect a new low frequency antigen Lia(Livesey) are described. The antigen is shown to be inherited as an autosomal dominant character, its possible linkage with the Lutheran blood group system is discussed.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04496.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.When the blood group H sites of cord erythrocytes obtained from newborn infants of groups O, A, B and AB were labelled specifically by incubation of the whole cells with the A1gene dependent a‐N‐acetylgalactosaminyl transferase in the presence of UDP‐N‐acetyl [14C]‐galactosamine, the incorporation of radioactivity was considerably lower than that found for cells from adults. Based on the amount of label recovered in the membranes, average values of 326,000 H sites per single O cell and 68,000 H sites per single A, B and AB cell were calculated. Following fractionation of the stromal blood group substances thus labelled, it was found that, on the average, 66% of the radioactivity was bound to glycoprotein material, 2.7% to glycosphingolipids with short carbohydrate chains, and about 24% to polyglycosylceramides. As these values are similar to those previously determined for O cells from adults, this result shows that there are probably no substantial differences between erythrocytes from adults and newborn infants concerning the overall membrane disposition, but rather provides evidence for variations in the carbohydrate chains of the stromal glyco

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04497.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04498.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04499.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.β2‐Microglobulin is a low molecular weight protein with sequence homology to immunoglobulins. As a portion of the HLA complex this protein is an important cell‐surface structure. Under normal conditions β2‐microglobulin is synthesized and shed by many cells, particularly lymphocytes, and is detectable in the circulation of normal individuals. Because of its small size it is normally filtered readily at the glomerulus and is catabolized by proximal tubular cells of the kidney. Impaired renal function and hyperproduction of β2‐microglobulin are both associated with increased serum levels. A function for β2‐microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune syste

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04500.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Two radioimmunoassay methods were used to determine levels of β2‐microglobulin in sera of lung and GI tract tumor patients (benign and malignant), as well as of normal individuals. Two screening sera panels were provided by the National Cancer Institute for this purpose. Statistical analysis of the results (performed by an independent institution) of the two panels provided discrepant results. This study points to the need of careful evaluation of results obtained by screening for any potential tumor mark

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04501.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Beta2‐microglobulin (β2m) content of several human tumor lines implanted into athymic mice was investigated. The concentration of this protein was found to vary greatly from tumor to tumor. The growth rate of the tumors was inversely related to the amount of the extractable β2m. The fastest growing, undifferentiated tumors contained the least amount of

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04502.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Serum levels of β2‐microglobulin (β2‐M) were found to be significantly elevated in acute viral hepatitis, chronic persistent or active hepatitis and liver cirrhosis. β2‐M values were significantly lower in chronic persistent hepatitis than in the three other groups. Serum β2‐M was normal in 75 asymptomatic carriers of HBsAg. Steroid therapy was followed by reduction of serum β2‐M levels in 11 cases of chronic active hepatitis. Variations of β2‐M were independent from that of transaminases, bilirubi

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04503.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.β2‐microglobulin (β2M) is a protein of 11,800 daltons which occurs in the plasma of normal individuals at concentrations of approximately 2 μg/ml. It is presumed to be relatively freely filterable. More than 99% of the filtered β2M is taken up by an active reabsorptive mechanism and catabolized by the renal tubule. The data presented here demonstrate that renal extraction is only slightly diminished by complete ureteral obstruction. The renal extraction of β2M is greater than can be accounted for by filtration alone. These data indicate that some uptake of β2M occurs from the peritubular capillary circulation. The loading of animals with β2M is associated with a marked tubular proteinuria suggesting that this protein may play a part in inducing tubula

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb04504.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY