摘要:

Abstract.An aggregate‐haemagglutination test has been used for determining antierythrocyte autoantibodies. The first antiglobulin variant of the test allows us to establish the presence of antibodies in 33 cases with a negative direct Coombs' test. The test II (antiantiglobulin variant) proved to be positive in 88 cases of autoimmune haemolytic anaemia (AIHA) that showed a negative direct Coombs' test and a negative antiglobulin variant. Immunoglobulin G has been revealed in the majority of AIHA patients. IgM has been determined in 1 case of a symptomatic form associated with chronic lymphocytic leukaemia. IgA has been recorded in 3 cases with an idiopathic AIHA form and in 6 cases of chronic lymphocytic leukaemia. Both types of light chains were found on the surface of erythrocytes in all cases of AIH

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04454.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Studies were performed on two anti‐N sera from patients who had formed anti‐N antibodies during their period of haemodialysis. No specific inhibition of these antibodies was obtained by extracts prepared from a new and a used dialysis unit, and it was concluded that there was no evidence of a compound in the units which would stimulate production of the anti‐N. The specificity of the anti‐N's was shown to be against a precursor of MN antigens, since all activity in the sera could be removed by neuraminidase‐treated M cells, which expressed MN precursor. Since the anti‐N's would react with untreated N cells only at 4 OC, but with formaldehyde‐treated cells at 4, 25 and 37 °C, it was concluded that the specificity of the anti‐N's was directed against an antigen developed by red cells after formaldehyde treatment. It is proposed that the production of the anti‐N antibodies is stimulated by formaldehyde‐treated red cells passing into the patient during re‐use of a dialysis unit steril

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04455.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The combined treatment with β‐propiolactone and ultraviolet rays described for the sterilization of HBSAg‐positive sera does not interfere with the purification procedures for the production of HBs antigen. The immunogenicity of the HBs antigen is reta

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04456.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Crude IgG precipitated from plasma by the addition of an equal volume of 4 M ammonium sulfate was fractionated on DEAE‐cellulose column to obtain pure IgG as shown by disc electrophoresis, immunoelectrophoresis and gel filtration. The processed IgG was free of plasmin and plasminogen and did not undergo fragmentation or aggregation on storage at 40 °C for at least 4 weeks. The anticomplement activity was low and the antibody activity was retain

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04457.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.A survey of HBsAg among Jerusalem blood donors revealed a prevalence of 0.89% and a predominance of subtypeuy(85%) compared withad(15%). A simultaneous survey of patients with HBsAg‐positive viral hepatitis revealed a similar predominance of ay(85%) compared withad (15%). The uniform distribution of the dominantaysubtype among both carriers and patients, representing a diversity of ethnic and national origins, supports the premise thatadandaysubtypes are preferentially correlated with regional epidemiologic, rather than host or disease‐related fact

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04458.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The addition to a 15‐channel blood‐grouping machine of two singlechannel antibody screening systems, based on the principles described by Marsh and Lalezari has produced a modified machine capable of detecting most clinically significant irregular blood group antibodies with a sensitivity equal to normal manual screening te

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04459.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Lymphocytes have been collected by continuous flow leukapheresis from cancer patients (pre‐treatment) and stored at ‐190 °C in liquid nitrogen as immunological support for intensive chemotherapy. Described here are methods for obtaining maximum yield and viability. Assessments are made of cell count, both during and after leukapheresis, and of viability just prior to sto

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04460.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.An antibody against ruminant (goat, sheep, bovine) IgM is described which also cross‐reacts with rabbit IgM. The antibody was found in the serum of a patient with adult coeliac disease and a selective IgA deficiency. This patient gave a false high Rose‐Waaler rheumatoid factor titre due to the presence of the serum antibody to rabbit IgM that was capable of agglutinating rabbit antibody‐sensitised erythro

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04461.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb04462.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY