摘要:

Summary.The effects and side effects of dextran and gelatin plasma substitutes relevant to the treatment of shock are reviewed. The physico‐chemical characteristics give the dextrans a certain lead over the gelatins with respect to molecular weight, intravascular volume effect and retention period. Experimental studies and clinical experience, however, have failed to demonstrate any difference of their therapeutic value, as revealed by survival data and suppression of shock‐induced metabolic alterations. Severe allergic reactions may occur with dextrans, but have not so far been recorded with gelatins. Hemostatic impairment limits the tolerated dose of clinical dextran, the risk of renal damage that of low molecular weight dextran. Similar side effects of the gelatins have not been documented. The risk of overtransfusion is greater with dextrans than with gelatins. The lower potency of the gelatins would appear, therefore, to be at least outweighed by their freedom from side effects, which enlarges the therapeutic margin of safety for shock treatment with artificial collo

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00387.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

Summary.An automated method for the detection of human Gm γG globulin antigens is described for Gm(f), (a), (b), (z).Detector red cells are sensitized with anti‐Rh serum or human Fr II γ‐globulin after chromic chloride treatment.The automated method is compared to present methodology and its advantages and disadvantages are disc

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00388.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

Summary.A subunit of the bovine erythrocyte membrane which resulted from ether and alkali extraction of stroma was found to retain possibly all of the blood group factors of the intact red blood cells. Factors in the A, B, C, F, L, S and Z systems were detected. Papain degradation of thiselininpreparation resulted in loss of all detectable factors except F, V and C when they were present in the source material. The F and V properties were clearly separated from each other. The F property remained with the insoluble residue while the V was found in soluble form in the reaction supernatant. The V factor could also be released from stroma by similar papain treatment. The F factor was destroyed by treatment with neuraminidase while no other factor was found to be affected. There was evidence that more sialic acid could be released by neuraminidase or by acid hydrolysis from F‐positive than from F‐negative erythrocyte str

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00389.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00390.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00391.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00392.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00393.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1969.tb00394.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY