摘要:

Abstract.To determine the viability of blood cells collected in half‐strength (0.5 CPD.A2) and full‐strength citrate anticoagulants, paired crossover autologous survival studies were performed in normal volunteers using51Cr‐labelled red cells after 35 days storage and111In‐labelled platelets after 5 days storage. For both studies, viability was better maintained in 0.5 CPD.A2 anticoagulant. This was significant for red cells (24‐hour survival: 80 ± 6 vs. 52 ± 21 %) but not for platelets by either linear or multiple‐hit models (recovery 51 ± 13 vs. 38 ± 14%, survival 5.1 ± 1.4 vs. 3.7 ± 1.5 days). The poor viability of red cells after storage in full‐strength anticoagulant was associated with low cellular adenosine triphosphate levels and was confirmed i

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03903.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.Two batches of heat‐treated factor VIII concentrate were found to contain anti‐HIV‐positive plasma donations. The batches were dry‐heat‐treated at 68 °C for 2 and 24 h, respectively. No HIV seroconversions occurred in 13 susceptible haemophiliacs receiving a total of 540 bottles of these factor VIII pr

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03904.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.A fatal transfusion reaction due to contamination of platelet‐depleted whole blood withPseudomonas fluorescensis reported. Routine sterility testing on blood products and environmental microbiological monitoring suggested no source for the contaminating organism, as has been the case for the majority of reported incidents of this type. The value of routine sterility testing in the prevention and investigation of such incidents is discusse

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03905.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.Abnormal amounts of platelet‐associated immunoglobulins (PAIg) and seropositivity for HIV were demonstrated in 18 haemophiliacs suffering from thrombocytopenia of varying severity. Among 34 non‐thrombocytopenic haemophiliacs seropositivity for HIV was found in association with increased levels of PAIg in 18 patients, whereas increased amounts of PAIg were seen only in 4 of the 16 patients seronegative for HIV. In most of the haemophiliacs with thrombocytopenia, the PAIg represented all classes of immunoglobulins and in half of the cases all subclasses of IgG, while in 33 patients with autoimmune thrombocytopenic purpura (AITP), PAIg was IgG1 and IgM in most cases. Our data show a difference in the pattern of PAIg in AITP patients and in thrombocytopenic haemophiliacs seropositive for HIV. We suggest that the thrombocytopenia in haemophiliacs is related to the polyclonal B cell activation also found in other patients seropositive for HIV and perhaps indicative of AIDS‐related co

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03906.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.The accumulation of the homozygous plasminogen (PLG) variant A3 in 4 siblings of a family led to the detection of 5 cases of apparent inverse homozygosity of PLG phenotypes which seemed to exclude paternity. Determination of 22 blood group markers and HLA typing, but under exclusion of PLG phenotypes, confirmed paternity in all cases (biostatistical probability of paternity>99.9985%). Comparing the results of ‘Western blots’ with functional‐caseinolytic phenotyping, the existence of inactive plasmin, as described earlier, could be excluded. Besides inverse homozygosity the assumption of a silent allele was confirmed by reduction of PLG antigenic levels and functional activities to approximately 50% of normal range. The PLG phenotype A in 1 individual with anamnestic thrombosis, reduced values of PLG antigen, and reduced functional activity, although in accordance with Mendelian inheritance, was also considered as indicative for PLG hemizyg

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03907.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.In this report 40 newly observed GC/DBP mutants are described. A list of the thus far identified GC mutants is presented: in addition to the three common alleles, a total of 124 Gc variants are recorded. Their population distribution is described and their relationship to the molecular features of the DBP protein is discussed. The methods currently in use for the delineation of GC mutants are briefly considered.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03908.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract.Separable anti‐T and anti‐Tk lectins can be extracted from the seeds ofVicia hyrcanica.The anti‐T lectin is similar to that of the peanut,Arachis hypogaea; the anti‐Tk lectin compares favourably with that ofGriffonia simplicif

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03909.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03910.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03911.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1988.tb03912.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY