摘要:

SummaryUsing125I‐labelled anti‐A and anti‐B, the number of A and B antigen sites per red cell for samples obtained from adults of different phenotypes was estimated to be: on A1cells, 0.81—1.17×106; on A1B cells, 0.46—0.85×105; on A2cells, 0.24—0.29×106; on A2B cells, 0.12×106. The number of sites on A1cells obtained from cord blood was 0.25—0.37×106, and on the single example of A2cord cells were 0.14×108sites. The number of B sites on adult cells were as follows: on B cells, 0.61—0.83×106; on A1B cells, 0.31—0.56×106sites.The equilibrium constants and the rates of dissociation of the reaction between anti‐A and A1and A2cells were also determined. The value of the equilibrium constant was approximately three times as great and the rate of dissociation three times as slow with A1cells compared to A2cells. This is consistant with the view that theere is a small difference in the molecular structure

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03362.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryThe presence of γG‐ and β1C‐globulin was demonstrated in the renal lesions of progressive intereapillary glomerulosclerosis (IGS) of aging and irradiated mice by means of fluorescent antibody techniques. The extent of deposits and intensity of fluorescence paralleled the severity of the disease. Evidence is presented that these deposits may represent local complexes of antigen‐antibody and complement. The possible role of ‘autoimmunity’ in the pathogenesis of the kidney lesions in aging and irradiated mice is considered in light of present studies and previous o

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03363.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

Summary183 samples of saliva were collected from women 2–6 days post‐partum and examined for the presence of anti‐A and/or anti‐B antibodies. The presence or absence of such antibodies was correlated to the presence or absence of maternal immune antibodies and cord antibodies of anti‐A and/or anti‐B specificity.In 27 group A mothers there were four with saliva anti‐B three of whom belonged to subgroup A2. Two group A mothers had children of group O who had anti‐A in the cord serum.In 11 group B mothers there were three with anti‐A agglutinins in their saliva.In 145 group O mothers there were 75 with saliva anti‐A, anti‐B, or anti‐A + anti‐B agglutinins. In the majority of cases, but not in all the saliva antibodies were destroyed by mercapto‐ethanol.The incidence of saliva antibodies varies with the blood groups, increasing from A1to B to A2to O. The significance of these findings is discussed.In group O persons there was a statistically significant association between the presence of saliva antibodies of the ABO system and(a) the presence of immune anti‐A + anti‐B in the corresponding maternal sera;(b) cross‐reacting eluates obtained from A cells after contact with corresponding maternal sera;(c) agglutination of Axcells by corresponding maternal sera;(d) and – in group O children – the presence of anti‐A and/or anti‐B antibodies in the corresponding cord sera.In the majority of cases the presence of saliva antibodies is closely associated with all four of these serological features; there are, however, instances when there is only association with one or two of them, in agreement with Landsteiner's statement, that antibodies formed in response to one determinant group are not ab

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03364.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryThe blood of a normal 38‐year‐old Japanese woman, Mrs. N. exhibited an unusual property in that (1) her red cells were inagglutinable or agglutinable very weakly by various anti‐B sera, (2) her cells failed to react with ordinary anti‐H reagents, (3) a trace of anti‐H was found in the serum, but (4) she secreted both B and H substances in her saliva.Her husband was group O and three of her children were normal group B and one was group O. To explain this finding, we propose the presence of a new, rare, modifying gene ‘w’ which suppresses, in the double dose, B and H substances in the cells without any effect on the se

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03365.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryIn vitroandin vivoimmune adherence experiments using egg albumen/anti‐egg albumen complexes are described. Injection of the immune complex into rabbits and monkeys induced increased destruction of cellular elements of the blood. The red cells of both immune adherence‐positive and immune adherence‐negative monkeys showed a diminished survival time after injection of the immune complex.The differing results obtained inin vitroimmune adherence experiments using rabbit and monkey anti‐egg albumen serum are di

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03366.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryEvidence was found that human lymphocytes and fibroblasts derived from human skin, sensitized by cytotoxic leucocyte iso‐antibodies and complement adhere to the surface of indicator cells. The reaction mechanism showed the characteristics of the immune adherence (I.A.) phenomenon. Experiments made clear that in the I.A. assay the same antibody is detected as in the cytotoxic antibody test, based on dye exclusion. The sensitivity of the I.A. assay was shown to surpass slightly that of the cytotoxic antibody tes

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03367.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

摘要:

SummaryThe present study has shown that the routine practise of antenatal manipulations such as external version is associated with a significant increase in the frequency of episodes of Rh immunization not only among Rh negative mothers who were already immunized before the present pregnancy commenced but also among those not previously immunized.The findings would seem to indicate that the disruption of the placental circulation is enhanced by such procedures and the ultimate risk involved in intensifying the haemolytic process ‘in utero’ can therefore not be igno

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03368.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1967.tb03369.x

出版商:Blackwell Publishing Ltd    

年代:1967

数据来源: WILEY