摘要:

Abstract.To obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. The parameters studied included cell indices, enzyme activities and rheological characteristics. Further, the life‐span of aged cells was compared to normal, and the sequestration site was determined.Mice erythrocytes, like those of rats, experienced a continuous decrease in MCV1, an early rise in MCHC, and late MCH reduction. In ageing rat erythrocytes the activities of HK, GR and 6‐PGD did not fall below the normal range during the first nine tenths of the potential life‐span. On the other hand, a borderline reduction of PK activity was found, and the activity of G‐6PD underwent a steady though unimpressive decrease to 70% of the physiological average. Aged erythrocytes, forced through 15‐μm capillaries differed in apparent viscosity from reticulocytes and normal cells by a factor of 1.31 and 1.16, respectively. Destruction of senescent cells was predominantly confined to the spleen, and prolonged erythrocyte survival followed s

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02809.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.A new antibody specificity, anti‐Rga, which detects an inherited antigen on red cells and in serum, reacts with 97% of individuals in the British populatio

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02810.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Serum IgA levels of 35 healthy IgA‐deficient index cases, of their 180 first‐degree relatives, and of 31 other family members were studied. IgA deficiency was detected in 7.2% of the first‐degree relatives, which is significantly more than the 0.25% frequency of IgA deficiency in healthy Finnish blood donors. Subnormal serum IgA levels were found in additional 13 (7.2%) first‐degree relatives. The familial clustering of IgA deficiency seemed to be controlled by multigenic factors.IgA‐deficient persons and their family members were tested for antinuclear and antithyroid antibodies, for rheumatoid factor (by latex test) and for other anti‐IgG antibodies (by Ripley test). Antibodies against bovine milk were also studied. The relatives of IgA‐deficient persons did not have more of these antibodies than the controls. It is suggested that various serological abnormalities are a consequence of the IgA deficiency rather than of genetic

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02811.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Prevalence of HBsAg was studied by counterelectrophoresis (CEP) in 65,795 consecutive volunteer blood donors in Israel. The overall prevalence of HBsAg was 1.22%. HBsAg was more prevalent in the young donors, more prevalent in male donors and varied according to the country of origin of the donors. The prevalence of HBsAg was 0.63% among donors born in Europe or the Americas and 2.83% for those born in Asia or Africa. The HBsAg prevalence among native Israelis followed the same pattern with higher prevalence rates among those born in Israel whose families came from Asia or Africa than those from Europe or America. The prevalence of Anti‐HBsby CEP was studied in 39,519 donors. The prevalence of antibody was higher in females and was higher in the same ethnic groups in whom there was a relatively high HBsAg prevalenc

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02812.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The titre of IgG anti‐A/B was determined by means of a 2‐mercaptoethanol test in the serum of 80 blood group O mothers, who gave birth at term to A/B incompatible infants, who developed early neonatal jaundice with a serum bilirubin level of over 10 mg/100 ml. The titres were compared with the results of the direct antiglobulin test performed on the red cells from the cord blood and the necessity for exchange transfusion. Only in mothers of group A infants, a significant correlation was found between the titre of IgG anti‐A and the occurrence of a positive antiglobulin test. In no case the need for an exchange transfusion was correlated with the IgG anti‐A/

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02813.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The H‐content of the red cells of 52 Ugandan Africans and 53 Europeans, all of group O, was measured using agglutination with an extract ofUlex europaeus.There was no appreciable difference between the scores in the two population

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02814.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The action of strong B gene on A1, subgroup of A is demonstrated in a family of 18 individuals. The inheritance of A2↑ BHWand A2BHWis explained. Attention is drawn to these subgroups in parentage studies, especially in African

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02815.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Incomplete anti‐Lec, anti‐Led, anti‐Les(anti‐Leb+Led), anti‐Lens(anti‐ Lea+Lec), anti‐Lem(anti‐Leb+ Lec) and anti‐Lex(anti‐Lea+Leb) antibodies were prepared by the immunization of goats with boiled saliva, absorbing the resulting sera with tryps

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02816.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The investigation of two examples of anti‐Rgaled to the observation that the phenotype HL‐A 1,8 occurs very frequently among Rg(a–) indivi

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02817.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Six further examples of haemagglutinins fromSalviaare reported; one is anti‐T and five are anti

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02818.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY