摘要:

Abstract.Remarkable differences were observed when 1,465 healthy Caucasian individuals and 128 healthy Negro individuals were compared for the genetic distribution of 25 different HLA antigens. Caucasians had a significantly higher frequency of A1, A3, B8, and Bw16, and Negroes of A28 and Aw30. The haplotype which had the highest incidence as well as the greatest positive linkage disequilibrium was A1‐B8 among Caucasians and A2‐B12 among Negroes. Genetic distance between the two races was 0.0592.The 89 Caucasian patients with renal failure did not demonstrate any significant deviations in phenotype frequencies (PF) of various antigens, when compared with healthy Caucasians; however, 48 similar Negro patients had twice as high an incidence of Bw17 as the healthy Negroes.No significant deviation in PF was observed in 77 Caucasian patients who had leukemia; however, 32 Caucasian patients who had back pain (24 also had back stiffness) due to spondylitic, arthritic or disc syndrome, had a significant increase of Bw16 and of B27, and a decrease of B12, when compared to Caucasian contr

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02206.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.A chromatographical study was made of eight antisera containing either anti‐HL‐A antibodies, cold lymphocytotoxins, or a mixture of both types of antibodies. The results vary according to the sera obtained. Usually cold lymphocytotoxins are sited in the IgM peak and anti‐HL‐A antibodies in the IgG peak, but there are some sera where anti‐HL‐A reactivity is IgM and cold lymphocytotoxic reacti

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02207.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autoimmune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the anti‐erythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the isotypic subclass, but also the genetic markers of these molecules. Evidence was obtained that the anomalous production of antierythrocyte autoantibodies is polyclonal, that these autoantibodies belong mainly to the IgG1 isotypic subclass, and that they have a preference for the Gm(1) allotype. In addition, certain of the findings point to a preferential expression of the Gm(1,21) haplotyp

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02208.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.A method for detecting traces of β‐propiolactone, which was previously described by Schmitz‐Masse, has been modified and adapted to the analysis of protein solutions. Using this method, the rate of hydrolysis of β‐propiolactone (β‐P1) was examined and β‐P1 sterilized commercial products were analyzed for possible residual nonhy

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02209.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.ACD blood was preserved in glass bottles with or without aeration and in plastic bags in air or nitrogen gas at 4.5°C. The blood was examined for physical and chemical changes of erythrocyte membrane resistance, hemoglobin in the plasma, the viscosity of the blood, pH of plasma, and ATP and 2,3‐DPG content of erythrocytes. The blood preserved in plastic bags showed less changes than blood in glass bottles. The presence of air or nitrogen gas in blood seems to increase the pH perhaps by elimination of carbon dioxide (CO2) which in turn causes the different rates of glycolysis in the erythrocyt

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02210.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Melanesians of groups O, A1and B all show greater variation of H antigen strength than do Caucasians. This is least marked in O bloods. Although the average H content of Melanesian and Caucasian samples did not differ significantly, 10% of O and over 20% of A1and B bloods from coastal Austronesian speakers had higher H than was found among Caucasians. There is evidence that some non‐Austronesian populations in New Guinea have twice this incidence of A1high H.Melanesian and BantuH, A1andBgenes appear to function similarly, in that theirBgenes act more effectively than Caucasian, theirA1genes less so, whileHproduces greater variation. It is suggested that this gene interaction, rather than the significantly greater availability of H or substrate in the Bantu, causes the observed variations from the Caucasian pattern found in the other races.Subjects with selective antigenic depression were excluded from the comparative studies, but the relevance of this phenomenon to apparent H content in Melanesians is discusse

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02211.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.A simple radioimmunologic procedure for the detection of anti‐hepatitis B antibody using the125I Ausria kit (Abbott) is described. The rapidity, sensitivity and high specificity of this method are underline

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02212.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02213.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1976.tb02215.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY