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11. |
Acute and Long-Term Effects of Therapy with High-Dose Furosemide in Chronic Hemodialysis Patients |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 351-356
Rudolf W. van Olden,
Joseph J.M. van Meyel,
Paul G.G. Gerlag,
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摘要:
The effects of daily administration of 250-2,000 mg furosemide (F) were studied in patients on hemodialysis who still had residual renal function. In a short study, 10 patients (endogenous creatinine clearance 0.6-5.3 ml/min/1.73 m2) used 1,000 mg F twice daily during 7 days, and in a long-term study 13 patients (endogenous creatinine clearance 0.7-6.8 ml/min/1.73 m2) were treated during 1 year with 250-1,000 mg F orally each day. In the short study, we observed an increase in the 24-hour volume excretion with a median of 109% (p < 0.005). Urinary sodium excretion increased 210%, chloride 346% and potassium 65% when compared with the control period. In the long-term study, a marked initial rise in diuresis and electrolyte excretion was found. However, during a 1-year follow-up, a gradual decrease in response with time was found caused by progression of renal disease. There were no signs of ototoxicity. Side effects were bollous dermatosis on the limbs after exposure to sunlight during the summer (3 patients). We conclude that high-dose F is effective in patients on hemodialysis with residual urinary production. However, in the long term, the diuretic effects diminish because of progression of the underlying renal disease.
ISSN:0250-8095
DOI:10.1159/000168471
出版商:S. Karger AG
年代:1992
数据来源: Karger
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12. |
Blood Lactate Is Reduced following Successful Treatment of Anaemia in Haemodialysis Patients with Recombinant Human Erythropoietin both at Rest and after Maximal Exertion |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 357-362
Andrew Davenport,
Eric J. Will,
Sudhir K. Khanna,
Alexander M. Davison,
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摘要:
The effect of increasing haemoglobin by erythropoietin therapy on exercise capacity was investigated in 11 regular haemodialysis patients, previously transfusion dependent. Exercise work load increased from a median of 100 W (95% confidence limit, 25-135) to 120 (45-180; p < 0.05) following erythropoietin, and the duration of the exercise test from 13 (3.5-20) to 15.5 min (4-22; p < 0.05). Resting blood lactate concentration decreased from 0.8 (0.6-1.6) to 0.3 mmol/l (0.3-0.4), p < 0.05, following treatment with erythropoietin, as did blood lactate concentration at maximal exertion from 2.0 (1.0-4.1) to 1.8 mmol/l (0.5-2.8; p < 0.05). In association with the increase in haemoglobin from a median of 6 (5.1-6.8) to 11.1 g/dl (11-11.9) following erythropoietin therapy, patients were able to achieve greater exercise capacity both in terms of maximum work load and duration of exercise in association with a reduced resting arterial lactate and a similar exercise-induced lactate production. This suggests that treatment had improved muscle function in terms of lactate production and/or utilisation. This was probably due to the increase in tissue oxygen delivery, as there was an increase in the median arterial oxygen content from 79 (65-85) to 150 ml O2 (144-157) following erythropoietin treatment.
ISSN:0250-8095
DOI:10.1159/000168472
出版商:S. Karger AG
年代:1992
数据来源: Karger
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13. |
Endocrine and Metabolic Disorders following Kidney Transplantation |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 363-368
Eben I. Feinstein,
Christoph Wanner,
Joachim Böhler,
Walter H. Hörl,
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ISSN:0250-8095
DOI:10.1159/000168473
出版商:S. Karger AG
年代:1992
数据来源: Karger
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14. |
Changing Concepts of Compensatory Renal Growth: From Humoral Pathology to Molecular Biology |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 369-373
Gunter Wolf,
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ISSN:0250-8095
DOI:10.1159/000168474
出版商:S. Karger AG
年代:1992
数据来源: Karger
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15. |
Serratia marcescensCellulitis in a Patient on Hemodialysis |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 374-376
Peter F. Bornstein,
Anne M. Ditto,
Gary A. Noskin,
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摘要:
Serratia marcescens is an infrequent cause of cellulitis with only 5 reported cases. Four of the 5 patients were immunocompromised. Additionally, the cellulitis usually occurred at a site contiguous with a wound. We report a case of S. marcescens cellulitis in a patient with end-stage renal disease on chronic hemodialysis. The initial presentation was a soft tissue infection that progressed to septic shock. Ultimately, the patient responded to antibiotics and surgical debridement of infected tissue. This case serves as a reminder to consider infections due to gram-negative bacilli as a cause of cellulitis in immunocompromised patients regardless of the presentation.
ISSN:0250-8095
DOI:10.1159/000168475
出版商:S. Karger AG
年代:1992
数据来源: Karger
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16. |
Profound Persistent Eosinophilia in a Patient with Spontaneous Renal Atheroembolic Disease |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 377-379
Jerrold Levine,
Helmut G. Rennke,
Beldon A. Idelson,
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摘要:
We describe an elderly women who died of renal failure secondary to spontaneous renal atheroembolic disease. The sole clinical clue to this diagnosis was a profound eosinophilia up to 19,100/mm3 and a relative eosinophil count of 80%. Renal atheroembolic disease should be a prominent consideration in any patient with both renal insufficiency and peripheral eosinophilia.
ISSN:0250-8095
DOI:10.1159/000168476
出版商:S. Karger AG
年代:1992
数据来源: Karger
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17. |
Renal Failure in Temporal Arteritis |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 380-383
Cesar G. Canton,
Carmen Bernis,
Vivente Paraiso,
Gillermina Barril,
Asuncion Garcia,
Carlos Osorio,
Begoña Rincon,
Juan A. Traver,
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摘要:
We report a case of biopsy-proven temporal arteritis and polymyalgia rheumatica with improved clinical symptoms with steroid treatment but with subsequent renal failure while on steroids. Kidney biopsy showed focal segmental necrotizing glomerulonephritis with crescents and small-vessel vasculitis. Treatment with methylprednisolone and cyclophosphamide achieved normalization of renal function. We emphasize the importance of kidney biopsy because of its therapeutic implications. The previous literature concerning renal disease in temporal arteritis is discussed.
ISSN:0250-8095
DOI:10.1159/000168477
出版商:S. Karger AG
年代:1992
数据来源: Karger
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18. |
Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression? |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 384-386
Mohammed H. Al-Sulaiman,
Dujanah H. Mousa,
Jag M. Dhar,
Abdullah A. Al-Khader,
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摘要:
We report a patient who developed generalized Kaposi’s sarcoma (extensive skin and stomach lesions) 24 months after renal transplantation whilst on cyclosporin (CyA) and prednisolone. Kaposi’s sarcoma disappeared completely upon withdrawal of CyA. The patient remained with a well-functioning graft and free of Kaposi’s sarcoma for 36 months on prednisolone alone. CyA was reintroduced following an episode of acute rejection. Within 8 weeks, Kaposi’s sarcoma reappeared on the skin at the same sites as the previously healed lesions. They completely disappeared again upon withdrawal of CyA. Azathioprine was then introduced and Kaposi’s sarcoma lesions reappeared 6 mon
ISSN:0250-8095
DOI:10.1159/000168478
出版商:S. Karger AG
年代:1992
数据来源: Karger
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19. |
Nephrotic-Range Proteinuria in a Patient with High Renin Hypertension: Effect of Treatment with an ACE-lnhibitor |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 387-389
Dino Docci,
Giovanni Moscatelli,
Claudio Capponcini,
Leopoldo Baldrati,
Carlo Feletti,
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摘要:
A 65-year-old man presented proteinuria in the nephrotic range that occurs in the setting ofhigh renin hypertension. Proteinuria persisted after normalizing blood pressure by nifedipine. In contrast, treatment with an ACE-inhibitor (enalapril) resulted in the prompt resolution of the proteinuria. Interestingly, proteinuria relapsed after removing the ACE-inhibition. These observations suggest a causal relation between the overactivity of the renin-angiotensin system in this patient and his proteinuria.
ISSN:0250-8095
DOI:10.1159/000168479
出版商:S. Karger AG
年代:1992
数据来源: Karger
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20. |
Decreased Response to Human Recombinant Erythropoietin Therapy in Pregnancy |
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American Journal of Nephrology,
Volume 12,
Issue 5,
1992,
Page 390-390
Cem Sungur,
Nurol Arik,
Unal Yasavul,
Cetin Turgan,
Sali Caglar,
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ISSN:0250-8095
DOI:10.1159/000168480
出版商:S. Karger AG
年代:1992
数据来源: Karger
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