ISSN:0250-8095    

DOI:10.1159/000166723

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Secondary oxalosis is a complication of renal failure. Since oxalate is excreted by the kidney, the severity of oxalate deposition has been directly related to the duration of renal failure. We report a patient with acute renal failure on hemodialysis who received daily ascorbic acid (an oxalate precursor) via parenteral alimentation. He developed widespread secondary oxalosis, which was especially prominent in the kidneys and pancreas. This oxalate burden may have contributed to the complications seen during his hospital course. The provision of ascorbic acid to patients with renal failure should be carefully monitored to avoid accelerated development of secondary oxalosis.

ISSN:0250-8095    

DOI:10.1159/000166724

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The glomerular ultrastructure was retrospectively reviewed from 45 renal transplant biopsies with the clinical and light microscopic diagnosis of acute rejection (25 cases) and chronic rejection (20 cases). Three grades of morphologic alteration were ultrastructurally defined. In acute rejection, capillary lumenal obliteration with endothelial cell hypertrophy and cellular infiltration were interpreted as the local glomerular expression of the endothelial vascular alterations of acute humoral rejection and were correlated with a poor graft survival. Graft nephrectomy was necessary in 9 of 11 patients with grade III glomerulopathy. In chronic rejection, thickened basement membranes and increased amount of mesangial matrix were considered the result of ischemia. The degree of ultrastructural glomerular alterations in chronic rejection did not correlate with graft survival. Urine protein values were consistently elevated, although poorly correlated with the severity of glomerular alterations. Recurrent glomerulonephritis was not documented in any case. We concluded that the glomerular alteration in acute rejection is a component of acute humoral rejection and that the degree of glomerulopathy in acute rejection is a good predictor of the graft survival.

ISSN:0250-8095    

DOI:10.1159/000166725

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Clinical data from 41 patients with pericarditis or pericardial effusion in acute and chronic renal failure were analyzed in respect to the diagnostic relevance of humoral immune reactions. In patients with pericardial effusion in acute renal failure due to surgery or trauma (n = 10), antimyocardial antibodies were rarely detected. In contrast, in the sera of all patients with pericarditis or pericardial effusion following renal failure in chronic or acute glomerulonephritis (n = 6), complement-fixing antisarcolemmal antibodies of the IgM and IgG classes were observed. In patients in whom pericarditis or pericardial effusion evolved during chronic hemodialysis (n = 25), the incidence of complement-fixing antimyolemmal antibodies was 64%. Only sera with complement-fixing antimyolemmal antibodies induced cytolysis of vital adult cardiocytes in vitro suggesting that the antimyolemmal antibodies may not only play a diagnostic but also a pathogenetic role in ‘uremic’ pericarditis in v

ISSN:0250-8095    

DOI:10.1159/000166726

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

To clarify the association between proteinuria and congestive heart failure (CHF), 24-hour urinary protein determinations were obtained from 27 patients with objectively documented CHF, before and after therapy of the CHF. The results demonstrate that modest proteinuria is a frequent feature of CHF and that this proteinuria reverses promptly with successful CHF therapy. Proteinuria exceeding 500 mg/day occurred only in patients with acute pulmonary edema. However, there was no other correlation between severity of proteinuria and type or chronicity of CHF. When proteinuria exceeds 1 g/24 h or when proteinuria does not reverse within 2 weeks of successful CHF therapy, intrinsic renal disease should be suspected.

ISSN:0250-8095    

DOI:10.1159/000166727

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166728

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Mithramycin given as a single dose for the treatment of hypercalcemia has not been reported to cause renal dysfunction. A case is presented of nephrotoxicity following a single 25 μg/kg dose in a patient with underlying squamous cell carcinoma, obstructive uropathy, and hypercalcemia. Underlying renal impairment may magnify the nephrotoxicity of mithramycin

ISSN:0250-8095    

DOI:10.1159/000166729

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Percutaneous renal biopsy was performed in a surface coal miner with radiographic and histopathologic pulmonary changes consistent with acute silicolipoproteinosis who developed proteinuria and hematuria. Electron microscopic evaluation of the renal tissue specimen revealed a diffusely thickened glomerular basement membrane, foot process effacement, and dense lamellar inclusions in swollen glomerular epithelial cells, similar to those seen in Fabry’s disease. However, normal levels of plasma α-galactosidase A, normal urinary sediment glycosphingolipids and the absence of the clinical characteristics of Fabry’s disease excluded this diagnosis. This case illustrates that electron-dense lamellar inclusions, similar to those seen in Fabry’s disease, may be seen in other entities such as nephropathy associated with sil

ISSN:0250-8095    

DOI:10.1159/000166730

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166731

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166732

出版商:S. Karger AG    

年代:1983

数据来源: Karger