ISSN:0250-8095    

DOI:10.1159/000166911

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In Michigan from 1974 through 1981 the average annual end-stage renal disease (ESRD) incidence was 7.76 for males and 5.55 for females per 100,000 population. Those over 35 years of age had higher incidence rates. The average incidence for black ESRD patients was 20.75, compared with 4.78 for white ESRD patients. Thus, the risk of ESRD was 4.34 times higher in the black population. In 1981, the stated causes of ESRD in the ESRD population were diabetes mellitus (24.5%), hypertension (24.2%), and glomerulonephritis (20.9%). Black ESRD patients, compared to white, had relative risks of 3.8 for diabetes mellitus, 10.9 for hypertension, and 1.7 for glomerulonephritis. The ESRD point prevalence increased from 11.58 in 1974 to 31.68 in 1981. Males predominated over females; the sex-specific ESRD prevalence in 1981 being 36.74 and 26.83, respectively. Blacks predominated over whites; the black and white ESRD prevalences in 1981 were 80.27 and 24.81, respectively. Prevalence over these years increased faster for older age groups. Hemodialysis at a center has been the major ESRD treatment modality. The percentage of all ESRD patients on home hemodialysis steadily decreased from 1974 through 1981. Similarly, on a percentage basis, fewer patients were transplanted in 1981 than in 1974. The number of ESRD patients treated by chronic ambulatory peritoneal dialysis increased more than sevenfold from 1979 through 1981.

ISSN:0250-8095    

DOI:10.1159/000166912

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The mechanisms of hypotension during haemodialysis were investigated by studying cardiovascular reflexes, body fluid volumes, and osmolality in 11 patients with renal failure before and after haemodialysis and in 17 normal subjects before and after furosemide diuresis. Blood pressure and heart rate responses to tests of autonomic nervous function were unaffected in either group except that in the patients, head-up tilt after haemodialysis caused a fall in blood pressure. This was associated with a greater fall in cardiac output than before haemodialysis but with a similar rise in peripheral vascular resistance. Resting plasma noradrenaline levels were higher than normal, and the rise in plasma noradrenaline levels in response to tilt was unaffected by haemodialysis. Plasma renin activity rose in response to head-up tilt in normal subjects, but not in patients either before or after haemodialysis. Our studies indicate that changes in plasma potassium and osmolality or the possible peripheral circulatory effects of acetate do not impair the regulation of the circulation in response to haemodialysis. Haemodialysis does not reduce plasma noradrenaline levels. Impaired myocardial function in response to fluid depletion or unresponsiveness of the renin-angiotensin system may contribute to haemodialysis hypotension.

ISSN:0250-8095    

DOI:10.1159/000166913

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Clinical and pathologic findings are described in 14 patients whose main abnormality was an excessively thin glomerular basement membrane (GBM). The subjects were aged 11–51 years, the majority males: most were referred because of hematuria, but proteinuria was the main problem in 2, while hypertension or renal functional impairment was found in several, and 1 was in end-stage renal failure. A history of apparently similar renal symptoms was obtained in another 3 family members. In addition to GBM abnormalities, renal biopsy features included a slight mesangial matrix increase, occasional mesangial cell excess and often appreciable pedicel effacement. There were scanty electron-dense deposits. The mean thickness of the GBM varied from 206 to 301 nm, whereas in IgA nephropathy patients used as controls it was 356-464 nm. It is concluded that some of the lesions in adults are ‘benign’, and some progressive. ‘Thin membrane nephropathy’ is comparatively common among patients seen by the authors, and it is suggested that awareness of this condition will result more often in its re

ISSN:0250-8095    

DOI:10.1159/000166914

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Patients with chronic renal failure manifest reduced pressor response to norepinephrine (NE); this abnormality is at least partly responsible for the autonomic nervous system dysfunction observed in these patients. Since uremia is associated with increased levels of parathyroid hormone (PTH) and since PTH blunts the pressor effect of NE most likely via activation of prostaglandins, we have studied the relationship between blood levels of PTH and the reduced pressor response to NE in 17 uremic patients and we examined the effect of treatment with indomethacin on the response to NE in 9 uremic and 5 normal subjects. There was a significant negative correlation (r = -0.63, p < 0.01) between the changes in blood pressure and the blood levels of PTH in uremic patients. Treatment with indomethacin was followed by significant improvement or normalization of the pressor response to NE in uremic patients. These data are consistent with the notion that the decreased pressor response to NE in uremia is due to increased production of prostaglandins induced by excess PTH and provide a therapeutic tool for the treatment of some of the manifestations of autonomic nervous system dysfunction in uremia.

ISSN:0250-8095    

DOI:10.1159/000166915

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166916

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166917

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In a 3 3-year-old woman concurrence of a complete distal renal tubular acidosis (RTA) and lymphocytic thyroiditis with spontaneously resolving hyperthyroidism was observed. Until recently, the rare association of RTA and hyperthyroidism had been thought to be governed by nephrocalcinosis, via hypercalcemia and hypercalciuria. However, in this case, nephrocalcinosis was not present, but there were histological signs of renal interstitial mononuclear cell infiltration, and the RTA persisted despite the resolution of the hyperthyroidism. This observation supports the idea that immunological mechanisms may relate RTA and hyperthyroidism when the latter has an autoimmune origin.

ISSN:0250-8095    

DOI:10.1159/000166923

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect of hemodialysis in dogs receiving a constant infusion of cyanide with and without a simultaneous infusion of thiosulfate. The hemodialysis clearance of cyanide in the presence of thiosulfate was 38.3 ± 5.4 ml/min with an extraction ratio of 0.43 ± 0.06 (n = 4). Hemodialysis was found to increase the lethal dose of cyanide without thiosulfate infusion, and a further increase was noted with the thiosulfate infusion. Thiosulfate promotes mitochondrial metabolism of cyanide to thiocyanate. The end product, thiocyanate, is quickly removed by hemodialysis. We believe that the demonstrated effectiveness of hemodialysis in the treatment of acute cyanide intoxication is related not only to the hemodialysis clearance of cyanide, but also to the removal of its metabolic end product, thiocyanate. Based on our observations, we feel that hemodialysis is an effective adjunct in the treatment of acute cyanide intoxicatio

ISSN:0250-8095    

DOI:10.1159/000166918

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166919

出版商:S. Karger AG    

年代:1985

数据来源: Karger