ISSN:0250-8095    

DOI:10.1159/000166709

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In order to better define ocular dynamics during hemodialysis, we studied intraocular pressure (IOP) and anterior chamber depth (ACD) serially during both acetate and bicarbonate hemodialysis in 10 stable hemodialysis patients. IOP did not change significantly in any patient during dialysis. In contrast, however, ACD decreased significantly during acetate but not bicarbonate dialysis. ACD could be maintained during acetate dialysis by concomitant administration of mannitol. We conclude that acetate dialysis might adversely affect ocular dynamics in susceptible patients with glaucoma or recent ocular surgery. In such individuals administration of mannitol or use of a bicarbonate dialysate should be considered.

ISSN:0250-8095    

DOI:10.1159/000166710

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

We studied plasma, dialysate, and muscle carnitine levels in patients with stable chronic renal failure on hemodialysis, and intermittent peritoneal, or continuous ambulatory peritoneal dialysis (CAPD). In patients on hemodialysis, plasma carnitine levels fell from 46.2 ± 4.5 μmol/l (mean ± SEM) to 18.8 ± 2.7 μmol/l immediately after the procedure (p < 0.001). Depletion ofmuscle carnitine was found after hemodialysis (1,518 ± 273 nmol/gwet weight of tissue) compared to normal levels of 5,230.5 ± 142.7 nmol/g tissue (p < 0.01). However, the plasma and muscle carnitine levels remained in the normal range in patients on intermittent peritoneal dialysis and CAPD. We postulate that the rapid decline in plasma levels of carnitine caused by hemodialysis initiates unilateral transport of the compound from muscle to the plasma, thus depleting the skeletal muscle stores of car

ISSN:0250-8095    

DOI:10.1159/000166711

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

6 patients with end-stage renal disease, hypertension and anemia were studied to determine the effect of endurance exercise training on their blood pressure. Initial exercise capacities were low (VO2 max = 18 ± 2 ml/kg/min); however, their capacities increased (17 ± 9%, p < 0.05) after 14 ± 5 months of training. This was associated with reductions in the antihypertensive medications in the 5 patients initially requiring them, and decreases in both predialysis systolic and diastolic blood pressures. There were significant increases in hemoglobin concentrations (7.3 ± 0.4 to 9.8 ± 0.9 g%) and hematocrit levels (23 ± 2 to 30 ± 3%) during training with no changes in body weights, interdialysis weight gains or serum albumin concentrations. 6 nonexercising dialysis patients had no changes in these same variables over the same period of time. These results suggest that endurance exercise training will reduce blood pressure and improve anemia in some hemodialysis pa

ISSN:0250-8095    

DOI:10.1159/000166712

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Neutral proteinases of neutrophilic polymorphonuclear leukocytes were followed up cytochemically in blood smears of 12 patients submitted to regular hemodialysis treatment (RDT). Halo formation (ring-shaped area around each neutrophil due to protein degradation) was reduced in all patients with end-stage renal disease under RDT. Concomitant to the development of leukopenia, a maximal increase of the plasma levels of the granulocytic elastase in complex with αi-proteinase inhibitor was observed 3 h after starting hemodialysis (+409%; p < 0.001). On the other hand, the proteolytic activity of the plasma samples against azocasein as substrate, being significantly higher (+244%; p < 0.001) in RDT patients compared with healthy controls, decreased permanently during therapy (-71 %; p < 0.001; 3 h after initiation of the treatment). The mechanisms of release as well as of elimination of proteolytic activity due to RDT are discussed

ISSN:0250-8095    

DOI:10.1159/000166713

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166714

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000166715

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A 42-year-old man undergoing maintenance hemodialysis suffered an attack of acute pancreatitis. Convential treatment resulted in quick recovery. 10 days after its onset his hands and feet became swollen, hot, red and painful. Multiple intramedullary osteolytic lesions of the metatarsals, metacarpals and phalanges, with cortical destruction and a number of fractures were found. These lesions subsided over many weeks and did not recur. We believe that such acute osteolytic lesions following pancreatitis are not ‘renal osteodystrophy’ as such, but should be recognized as a possible complication in renal failure patie

ISSN:0250-8095    

DOI:10.1159/000166716

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The renin-aldosterone system and tubular responsiveness to exogenous mineralocorticoid administration was evaluated in 2 hyperkalemic patients with obstructive uropathy. Both patients manifested marked renal sodium wasting and a modest inability to lower urine pH despite systemic acidosis. None of the abnormalities was corrected with supraphysiologic doses of mineralocorticoid. In addition, plasma renin and aldosterone levels were inappropriately low. Thus, both hypoaldosteronism and renal tubular resistance to mineralocorticoids coexisted in these patients. It is likely that an association between these abnormalities is more frequent than previously recognized.

ISSN:0250-8095    

DOI:10.1159/000166717

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Development of Nil disease and focal segmental glomerulosclerosis (FGS) in sequential renal biopsies is reported in a patient with Hodgkin’s lymphoma. Although steroid resistance was demonstrated, a complete and sustained clinical remission of the renal lesion followed anti-Hodgkin’s chemotherapy. These findings support the hypothesis that Nil disease and FGS are manifestations of the same clinical ent

ISSN:0250-8095    

DOI:10.1159/000166718

出版商:S. Karger AG    

年代:1983

数据来源: Karger