ISSN:0148-7299    

DOI:10.1002/ajmg.1320180403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractUnder close scrutiny the perogative of self‐intelligibility thus attributed to present time is found to be based upon a set of strange postulates. In the first place, it supposes that, within a generation or two, human affairs have undergone a change which is not merely rapid, but total, so that no institution of long standing, no traditional form of conduct, could have escaped the revolutions of the laboratory and the factory. It overlooks the force of inertia peculiar to so many social creation

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractOn the occasion of the 200th anniversary of the birthday of Johann Friedrich Meckel the Younger (1781–1833) it is appropriate to examine his contributions to the field of clinical genetics. Special emphasis is given to his laws of “diversity” and “reduction.” These deal respectively with the evolutionary and developmentaldifferencesbetween organisms and the reasons forsimilaritiesin development of parts of an organism and the parts of different organisms. Meckel is an important pioneer of modern clinical teratology because he did not restrict his studies to normal development, but rather concentrated on its aberrations in his reflections on the history of de

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractIt is a pleasure for me to thank Sewall Wright for preparing and delivering the first Meckel oration, and I deeply appreciate the privilege of commenting on Dr. Wright's paper. The implications of Wright's work for clinical developmental genetics might not be completely clear to a nonclinical geneticist and I have therefore taken the liberty of distilling the following three major concepts out of Sewall Wright's writings on developmental genetics from 1923–196

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe process of transferring preimplantation embryos from the reproductive tract of one female to that of another, commonly referred to as embryo transfer(ET), has been used extensively for exploration of basic mechanisms of developmental genetics. ET has also permitted practical application of such basic knowledge to selective breeding of livestock and treatment of infertility. Contributions of mammalian embryo transfer are presented as they pertain to studies of heredity vs environment, gamete maturation, fertilization, differentiation, and genetic transformation. Future applications of embryo transfer to the study of developmental genetics are likely to include extensive use of microsurgical techniques on a wide variety of mammalian embryos.

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA male infant with the Meckel syndrome was studied anatomically. The findings were compared to those from eight trisomy 13 cases to determine whether or not the superficial similarities between the two syndromes were matched by similarities in the internal variations. Emphasis was on the head and limbs. In the head, major differences were found in the nasal bones, mandible, and tongue. In the limbs, the skeletal variations were more severe in the Meckel syndrome infant, but he lacked the muscle variations diagnostic of trisomy 13.

ISSN:0148-7299    

DOI:10.1002/ajmg.1320180412

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY