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11. |
Specificity of testosterone and estradiol in the differentiating neonatal rat |
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The Anatomical Record,
Volume 157,
Issue 1,
1967,
Page 79-86
Harvey H. Feder,
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摘要:
AbstractThose components of sexual behavior characteristic of the adult intact male such as intromission and ejaculation, were inhibited in males receiving estradiol dipropionate within the first week of life. Neonatal treatment with testosterone propionate at corresponding ages did not disrupt the capacity for homotypic behavior when the males became adult. The expression of female behavior during adulthood was suppressed in female rats treated during a critical period of early postnatal life with testosterone propionate or estradiol dipropionate.Spermatogenesis was suppressed in males receiving the estrogen but not the androgen in early postnatal life, whereas ovulation was suppressed in females receiving the estrogen or androgen at corresponding periods.It was concluded that testosterone is compatible with the normal development of male sexual characteristics but that estradiol is not compatible with development of female sexual characteristics when administered during a critical period of differentiation. The specificity for androgen in adult males is postulated to be partly due to the presence of androgens during the critical period. The specificity for estrogen shown by females in adulthood is thought to be dependent upon the absence of estrogen and androgen during a corresponding developmental stage.
ISSN:0003-276X
DOI:10.1002/ar.1091570112
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1967
数据来源: WILEY
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12. |
Postnatal development of sensitivity to estrogen and androgen in male, female and psuedohermaphroditic guinea pigs |
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The Anatomical Record,
Volume 157,
Issue 1,
1967,
Page 87-96
Robert W. Goy,
Charles H. Phoenix,
Richard Meidinger,
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摘要:
AbstractLordosis responses on the day of birth were measured in female pseudohermaphrodites, their male siblings, and control females and males. All subjects displayed lordosis. Differences in average duration of the response were not significant.Relationships between exogenous estrogen and display of lordosis at later ages were studied in gonadectomized subjects. At seven days, estrogen did not induce lordosis in any subject. All normal females displayed lordosis at 21, 35, 60, and 90 days, and estrogen‐sensitivity increased steadily. Pseudohermaphrodites failed to respond to hormones until 35 days, and responses were infrequent and abbreviated. Age at time of ovariectomy did not influence performance of pseudohermaphrodites. Males showed lowest responsiveness to estrogen over all ages.Pseudohermaphrodites resembled the male in postnatal responsiveness to androgen. Although postnatal testosterone induced mounting behavior in normal females, pseudohermaphrodites, like males, displayed more mounting and mounted at earlier ages.Results suggest that prenatal androgen has not impaired the neural mechanism for lordosis at birth. Rather it acts to alter, during the fetal stage, the mechanism which normally directs the development of estrogen‐sensitivity of the neural mechanism in the genetic female. Additionally, prenatal androgen lowers the hormonal threshold for mounting behav
ISSN:0003-276X
DOI:10.1002/ar.1091570113
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1967
数据来源: WILEY
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13. |
Effects of early postnatal androgen and estrogen injections on the estrous activity cycles and mating behavior of rats |
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The Anatomical Record,
Volume 157,
Issue 1,
1967,
Page 97-104
Arnold A. Gerall,
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摘要:
AbstractInjections of 0.25 mg estradiol benzoate and 1.25 mg testosterone propionate in five day old intact and spayed albino female rats either eliminated or shortened the period of the estral activity cycle. Greater than normal amplitude of running was associated with neonatal estrogen and lower than normal activity with androgen. All of the oil‐ but none of the steroid‐treated females exhibited normal receptivity to vigorous males after hormone replacement therapy. It was concluded that neonatally administered steroids modified neural centers mediating behavioral periodicity and mating as well as those involved in gonadotrophin rele
ISSN:0003-276X
DOI:10.1002/ar.1091570114
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1967
数据来源: WILEY
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14. |
Masthead |
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The Anatomical Record,
Volume 157,
Issue 1,
1967,
Page -
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PDF (30KB)
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ISSN:0003-276X
DOI:10.1002/ar.1091570101
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1967
数据来源: WILEY
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