摘要:

ABSTRACTIn this study we evaluated the effect of 1-year, subcutaneous desferrioxamine daily infusion on iron balance in 23 thalassemia major children, aged 8–74 months, with transfusional iron accumulation less than 3.8 g at the outset of the trial. Statistical analysis showed a significant correlation between transfusional iron accumulation and percentage of transfusional iron eliminated. Confidence limits analysis of these data indicated that over 3.5 g of transfusional iron load, 95% of the patients may achieve balance. The appropriate time to begin desferrioxamine infusion, therefore, seems to be after about 30 transfusions of packed red blood cells when iron accumulation of approximately 3 g is reached. As we found a statistically significant correlation between transfusional iron eliminated and serum ferritin levels, the evaluation of serum ferritin alone can also predict when balance can be obtained.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTNeurological, psychopedagogic, and psychologic long-term sequelae were evaluated in two groups of ALL patients in continuous CR for more than 2 years treated with two different CNS prophylaxis schemes. Group A, 19 patients (protocol 10-LLA-72 GATLA) received cranial irradiation 2400 rads plus IT MTX-DMT, and group B, 23 patients (protocol 1-LLA-76 GATLA) IT MTX-DMT only during induction and maintenance. All the patients were evaluated by performing neurological examination, EEG, EMG with nerve conduction velocity, CT scans, CSF studies, psychometric and psychologic studies, and neuropsychological evaluation. The most important findings were: 11 patients from group A (58%) showed abnormal CT (low density areas in the periventricular white matter, widening of subarachnoid space, ventricular dilatation, intracerebral calcification) and only one patient from group B showed CT abnormalities (p< 0.0005). The neuropsychologic evaluation (performed by L. Bender technique and Picq-Vayer scale) showed more severe impairment (grade 3–4) in eight patients from group A (42%) and none in group B (p < 0.001). Higher incidence of abnormalities in group A suggests the existence of more severe sequelae in the patients treated with cranial irradiation plus IT MTX-DMT than with IT MTX-DMT alone.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTA urinary assay (17 kgs/creatinine) was used to measure compliance in 31 acute lymphocytic leukemia patients under 15 years of age receiving oral prednisone. Demo-graphic data and psychological test responses of patients and their parents were correlated with the urinary assays. Results indicated that while the rate of compliance was the same for boys and girls, the psychological correlates were very different. Parental personality traits and attitudes were more involved with boy's compliance than with girl's. Some of the parent variables associated with compliance in boys were hostility, anxiety, and obsessive-compulsive behavior. Parents described compliant boys as vulnerable. These traits usually are considered maladaptive but in this case appear to facilitate boy's compliance. For girls, far fewer parent variables were associated with compliance. Parents seemed to have less worry and concern about their daughters and presumably give them the responsibility for their own medication. It was the girl's own anxiety which predicted compliance.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTAnthracycline compounds are useful agents in cancer therapy. Major toxicities include mucositis and other gastrointestinal complications, myelodepression and cardiotoxicity. With the current multimodal cancer therapy, anthracycline toxicities may be potentiated by radiation treatment or other chemotherapeutic agents. The choice of anthracycline, drug combination, and drug schedule should be carefully evaluated to minimize toxicity.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTCongenital hypoplastic anemia (CHA) is a rare entity characterized by selective depression of erythropoiesis. The disease was first described in 1938, in four patients reported by Diamond and Blackfan,(1)followed by a number of longitudinal studies and reviews(2)of approximately 175 well-documented cases and/or unpublished records. The typical patient presents in infancy (median 1 month of age) with pallor. In as many as 30% of the patients there is an inconsistent pattern of congenital anomalies of the heart, integument, musculoskeletal system, and kidneys.Although its congenital nature is firmly established, the pathophysiology is still unknown, and it is likely that there are multiple biochemical or cellular defects producing the same clinical syndrome.That the disease is genetically determined is suggested by some cases accompanied by congenital anomalies, by racial differences-only a few blacks and one Asian have been described-and by multiple occurrences in some families. The number of such families is small, and the mode of inheritance appears inconsistent.The purpose of this report is to emphasize the apparently variable genetics of a disease which is undoubtedly variable in its clinical expression. We describe the unique occurrence of CHA in half-siblings of opposite sex, both with moderately severe disease, transmitted by a healthy female.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID