摘要:

Lymphoblasts from 61 untreated patients with acute lymphoblastic leukemia (ALL), classified according to the French-American-British (FAB) morphologic classification, were studied for cytochemical characteristics and membrane surface markers. Seventy-three % (eight of 11) of patients with E-rosctte positive lymphoblasts (T ALL) had strong focal paranuclear acid phosphatase (AcP) activity in more than 75% of their lymphoblasts; lymphoblasts from only 6% (three of 48) (p= 0.005) of patients with E-rosette negative, surface immunoglobulin negative lymphoblasts (non-T, non-B ALL) exhibited this characteristic AcP activity.The non-T, non-B ALL cases that manifested focal paranuclear AcP activity had clinical features more characteristic of the T ALL cases. The distribution of β-glucuronidase activity in the lymphoblast cytoplasm was similar to that of AcP for T ALL and non-T, non-B ALL but the stain was generally more difficult to interpret than the AcP and was a less reliable indicator of immunologic type of ALL. The periodic acid-Schiff (PAS) and nonspecific esterase stains were not useful in distinguishing between T ALL and non-T, non-B ALL but PAS negativity was associated with certain clinical features within the non-T, non-B ALL group. Cytochemical evaluation of the lymphoblasts at diagnosis in patients with ALL may be useful in identifying subsets of ALL that have distinct immunologic and clinical characteristics and important therapeutic and prognostic implications.

ISSN:0192-8562    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTThirteen cases of childhood malignancy are described in which treatment was refused. Four groups are presented: 1) the parents refused treatment for a child with a good prognosis, 2) parents refused treatment for a child with a poor prognosis, 3) the patients refused treatment, and 4) child abuse or neglect occurred in conjunction with refusal of treatment. Parents refused treatment on the basis of religious grounds, seeking unproven methods of treatment, a conviction that treatment was worthless, or a feeling that treatment of the child interfered with the parents life-style. Children refused treatment because they did not like the therapy side effects, did not like painful procedures, or felt the disease was hopeless. Some families refused treatment at one point, then later asked to resume treatment. Management of these cases depends, to a great extent, on prognosis. Those children having a good prognosis can be called to the attention of the juvenile court on the basis of medical neglect. In children old enough to exercise their own consent, and in children with a poor prognosis, recourse to the juvenile court is not indicated. In all cases, frequent communication with the families is extremely important even when treatment has been refused.

ISSN:0192-8562    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTZinc status was studied in 47 children with homozygous sickle cell disease (SCD). Decreased hair and plasma zinc was demonstrated in these children and hyperzincuria was found in the older patients. This study indicates that zinc deficiency in patients with SCD is probably due to hyperzincuria.

ISSN:0192-8562    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTThe occurrence ofde novocancer in renal transplant patients who have received immunosuppressive therapy has been noted. An increased incidence of second primary neoplasm (SPN) has been reported in adults with various forms of cancer. The incidence of SPN in childhood cancer is lower. Successful therapy in several childhood cancers has resulted in prolonged disease-free survival time with the opportunity for longer patient-years of observation. The development of a SPN, an astrocytoma, in a child with acute lymphocytic leukemia who remained in continuous complete remission for more than 6 years is reported. The incidence of SPN in childhood cancer needs to be established.

ISSN:0192-8562    

出版商:OVID    

年代:1979

数据来源: OVID