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1. |
Prognostic significance of the acute lymphoblastic leukemia (ALL) cell‐associated antigen in children with null‐cell ALL |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 99-102
Elaine Morgan,
Clement Hsu,
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摘要:
ABSTRACTThe leukemic cells of 50 children with nullcell acute lymphoblastic leukemia (null‐ALL) were studied at the time of diagnosis for the presence or absence of an ALL cell‐associated antigen (ALLA). Eleven of the patients were ALLA (−) and the remainder were ALLA(+). The clinical courses of these patients were followed prospectively for 2‐34 months. In the ALLA(−) group, 7 of 11 patients suffered a disease‐related adverse event [induction failure; bone marrow (BM), central nervous system (CNS) or testicular relapse; death] by 13 months from diagnosis. In the ALLA (+) group, there were seven disease‐related adverse events in 39 patients within 29 months after diagnosis. The difference in the incidence of diseaserelated adverse events between the two groups is statistically significant, i.e., 7/11 versus 7/39 (p= 0.005 by Fisher's Exact Test). The results suggest that children with ALLA(−) null‐ALL have a poorer prognosis than those who are ALLA(+).
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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2. |
DIP following chemotherapy for acute lymphocytic leukemia |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 103-110
Lawrence Frankel,
Fred Atkins,
Gordon Flake,
Alberto Ayala,
Carlos Bedrossian,
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摘要:
ABSTRACTA 6‐year‐old male with a 2‐year history of acute lymphocytic leukemia presented with insidious onset of chronic respiratory disease. In the process of evaluating the patient for an opportunistic infection, a lung biopsy was performed. The diagnosis of desquamative interstitial pneumonia (DIP) was made. This paper considers the occurrence of DIP in children as discussed in the world literature. The diagnosis of DIP in a patient with immunosuppression secondary to drug therapy for leukemia is advanced as another etiology for this nonspecific pulmonary reaction.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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3. |
Urinary excretion of iron in response to subcutaneous deferoxamine in sickle cell anemia |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 111-114
Daniel Ambruso,
Barry Mahony,
John Githens,
Stephen Wallner,
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摘要:
ABSTRACTFour patients with sickle cell anemia and evidence of increased iron load documented by serum ferritin levels were given 3 g deferoxamine (DF) by subcutaneous route over 12 hours. Each patient was supplemented with 500 mg vitamin C given daily. These studies were part of an initial evaluation for a transfusion program designed to keep the hemoglobin above 11 g/100 ml. Transfusion therapy was instituted in these patients because of severe complications of sickle cell disease including cerebrovascular accidents, incapacitating crises, disabling bone infarctions, and unusually severe anemia. Urinary excretion of iron ranged from 12.2 to 28.6 mg for 12 hours during and 36 hours after the infusion of DF. The pattern of excretion indicates that increased iron excretion occurred for the 12 hours of the infusion as well as 12 hours after the end of the infusion. DF given by the subcutaneous route appears to be an efficient and practical method for treatment of iron overload in patients with sickle cell anemia.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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4. |
Bone imaging as a diagnostic aid in evaluating neuroblastoma |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 115-118
John Sty,
Larry Kun,
James Casper,
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摘要:
ABSTRACTA clinical study comparing the sensitivity of the radionuclide skeletal survey to the radiographic skeletal survey and random iliac crest bone marrow aspiration in detecting metastatic disease in children with neurogenic tumors is presented. No false negative bone images for metastases were obtained during the initial evaluation. Uptake of tracer in the primary tumor was a frequent finding. The radionuclide survey is recommended in the initial evaluation of neurogenic tumors.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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5. |
INTRODUCTION |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 119-120
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ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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6. |
Childhood red cell aplasia |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 121-140
Blanche,
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摘要:
ABSTRACTChildhood red cell aplasia is defined as anemia, with reticulocytopenia, and usually bone marrow erythroid hypolasia. The congenital disorder is called Diamond‐Blackfan anemia. The acquired disease is short‐lived, termed transient erythroblastopenia of childhood. The onset of Diamond‐Blackfan anemia is usually prior to age 2 years. One‐third have some physical abnormality. Erythroid progenitor cells are decreased in number and relatively insensitive to erythropoietin in tissue culture. Steroid treatment leads to clinical response in two‐thirds. During steroid‐induced or spontaneous remission, patients demonstrate fetal erythropoiesis. TEC occurs between ages 1 and 6 years. Physical examinations are normal. Spontaneous remissions occur rapidly. Erythrocytes are initially adult in character; fetal erythrocytes appear transiently during the recovery phase. Full recovery is expected.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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7. |
Transitory bone marrow failure: A series of 13 preleukemic cases in children |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 141-144
Jean,
Bernard G.,
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摘要:
ABSTRACTThe occurrence of a transitory bone marrow aplasia followed shortly thereafter by acute leukemia is a rare clinical occurrence in children. We report 13 observations involving children between 6 months and 10 years of age. Splenomegaly was observed in five patients and hepatomegaly in two. There was a tricytopenia in five cases, bicytopenia in four, and an isolated cytopenia in the remaining four cases. The phase of marrow aplasia was short, lasting from 6 to 30 days. Complete bone marrow recovery occurred. Remission was spontaneous or followed transfusion or corticosteroid therapy and lasted for 2‐6 months. The leukemia had no particular character when it appeared: There was one case of acute myeloblastic leukemia, 11 cases of acute lymphoblastic leukemia, and one sarcoma. Median survival time was 5‐32 months and there were no relapses of marrow aplasia. In these cases, it cannot be determined whether there is an initially nonleukemia marrow aplasia or if leukemia is present at the onset but undetected, camouflaged, or confined to a few small foci.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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8. |
Bone marrow transplantation for severe aplastic anemia in children: Progress and problems |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 145-154
Bruce,
Camitta Joel,
Rappeport Robertson,
Parkman David,
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摘要:
ABSTRACTEighty percent of children with severe aplastic anemia die despite optimal current medical therapy. Survivors frequently have incomplete hematopoietic recovery. In contrast, following treatment of severe marrow aplasia by histocompatible bone marrow transplantation, more than 50% of the children survive—hematologically normal and free from sequelae of the disease or its treatment. However, the pathogenesis of aplastic anemia remains unknown, most children do not have histocompatible donors, and considerable morbidity from infection and graft versus host disease occurs following transplantation. Bone marrow transplantation represents significant progress in treatment of a lethal disease; many challenges and problems remain.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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9. |
Application of hematopoietic stem cell cultures in bone marrow failure |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 155-162
Melvin,
Freedman Fred,
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摘要:
ABSTRACTTissue culture assays of human hematopoietic progenitor cells have advanced the study of the physiology of hematopoiesis at its early stages and have yielded knowledge of some of the factors that regulate cell differentiation and replication. Our understanding of the pathophysiology of various forms of bone marrow failure has also increased and will provide a more rational basis for treatment. Since immune mechanisms of marrow failure can be distinguished from intrinsic hematopoietic stem cell defectsin vitro.the culture assays should allow an appropriate selection of disorders and individuals to be treated by bone marrow transplantation.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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10. |
SEMINAR BIO‐LINES |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 2,
1980,
Page 163-164
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ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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