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1. |
Transient autoimmune neutropenia due to anti‐NA1 antibody |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 195-200
John Priest,
Mary Clay,
Jeffrey McCullough,
Norma Ramsay,
Parviz Lalezari,
William Krivit,
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摘要:
A 6-month-old girl developed severe, but transient neutropenia due to an antibody against a neutrophil-specific antigen, NA1. The mean absolute neutrophil count was 380/μ1 for 2 months and spontaneously returned to normal as the anti-NA1 antibody disappeared. After recovery, the NA1 antigen was demonstrated on the patient's neutrophils. No etiology was found. There was no therapy directed at suppressing the antibody or increasing the neutrophil count. Life-threatening infection did not occur during the neutropenia.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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2. |
Function studies of monocytes from patients with cyclic neutropenia |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 201-206
Amos Deinard,
Glenda Geehan,
Arthur Page,
Beulah Holmes,
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摘要:
In vitrostudies of peripheral blood monocytes from patients with cyclic neutropenia have shown them to be able to phagocytize and kill bacteria as efficiently as PMN's, but not monocytes, from normal controls at both low and high ratios of bacteria to leukocytes. Monocytes from these patients, as well as from normal controls, are able to respond to chemotac-tic stimuliIn vitro. In vivoRebuck skin-window studies revealed the mononuclear cell response to be normal in these patients, even in the complete absence of circulating and inflammatory exudate neutrophils. These findings suggest that peripheral blood monocytes from patients with cyclic neutropenia are as phagocytically and bactericidally competent as normal peripheral blood neutrophils. As “stimulated” cells, they may serve as an effective line of defense against bacterial infections during periods of neutropenia in these patients.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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3. |
Selective deficiency in collagen‐induced platelet aggregation during L‐asparaginase therapy |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 207-212
Ralph Shapiro,
Jonathan Gerrard,
Norma Ramsay,
Mark Nesbit,
Peter Coccia,
Steven Stoddard,
Edward Plow,
James White,
William Krivit,
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摘要:
Platelet aggregation studies were performed on 10 pediatric patients with acute lymphoblastic leukemia (ALL) receiving induction therapy with vincristine, prednisone, and L-asparaginase. An isolated abnormality in platelet aggregation in response to collagen was found in all patients during the course of therapy. Platelet aggregation in response to collagen normalized following the discontinuation of L-asparaginase, while patients were still on vincristine and prednisone. In contrast to the abnormal collagen response, platelet aggregation induced by epinephrine, arachidonic acid, adenosine diphosphate (ADP), and thrombin were normal both during and following therapy. In the one patient with a normal platelet count before therapy, aggregation induced by all agents was normal. This selective abnormality in collagen aggregation therefore appears to result from therapy, with the use of L-asparaginase in particular being implicated.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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4. |
Studies on some coagulation factors (Hageman factor, plasma prekallikrein, and high molecular weight kininogen) in the normal newborn |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 213-216
Erlinda Gordon,
Oscar Ratnoff,
Hidehiko Saito,
Samuel Gross,
Paul Jones,
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摘要:
Normal newborn infants have a prolonged partial thromboplastin time compared to that of older infants or adults. This finding has been related to combined deficiencies of multiple clotting factors, with the exception of proaccelerin (factor V) and antihemophilic factor (factor VIII). The present study confirms the presence of decreased titers of Hageman factor (HF, factor XII), plasma prekallikrein, and high molecular weight kininogen during the neonatal period, as demonstrated in clotting assays; the degree of these relative deficiencies is usually such that only the low titer of HF appears to contribute significantly to the abnormally long PTT. Additionally, procoagulant titers of HF and plasma prekallikrein were relatively lower than the concentration of these factors determined immunologically. The mechanisms underlying this phenomenon are not known.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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5. |
A study of the cross‐resistance of vincristine and vindesine in reinduction therapy for acute lymphocytic leukemia in relapse A report for Children's Cancer Study Group |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 217-222
W. Krivit,
J. Anderson,
R. Chilcote,
A. Pyesmany,
R. Chard,
D. Hammond,
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摘要:
The vinca alkaloid modification product, vindesine, presents closely related molecular structure to vincristine. Although there are differences in capacity to bind tubulin dimer and inability to inhibit growth of several experimental tumors, there is a significant degree of overlap. In the clinical tests to date, vindesine has been used in treatment of children with relapse of acute lymphocytic leukemia considered to be resistant to vincristine. The study presented here was designed to assess the degree of overlap between vincristine and vindesine. The conclusion was reached that there is clinical cross-resistance.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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6. |
Aplastic Anemia, continuedImmunologic mechanisms in aplastic anemia |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 223-232
Jonathan Finlay,
William Ershler,
Nasrollah Shahidi,
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摘要:
The existence of abnormalities of the immune system in patients with aplastic anemia is controversial. Review of the evidence for immune deficiency as a component of the aplastic process in these patients reveals generally intact lymphocyte function, but a variable degree of monocyte impairment.Evidence is presented that excessive T-lymphocyte activity may be implicated in the pathogenesis of aplastic anemia, but this is complicated by the possible induction of such suppressor cells in response to blood transfusions.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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7. |
Role of cell‐cell interaction in normal and abnormal erythropoiesis |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 233-244
Esmail Zanjani,
John Rinehart,
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摘要:
A number of studies have demonstrated that certain immunocompetent cells play a role in the regulation of normal erythropoiesis. These regulatory cells (monocytes-macrophages, lymphocytes) modulate almost every phase of the erythropoietic process, and along with erythropoietin represent the major controlling force in erythropoiesis. Evidence indicate that pathological alterations of these cell-mediated activities can lead to clinical disturbances of red cell production such as is seen in patients with Diamond-Blackfan syndrome and aplastic anemia.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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8. |
Histiocytic medullary reticulosis associated with acute Epstein‐Barr (EB) virus infection |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 245-248
Ronald Cohen,
John Hutter,
Michael Boxer,
David Goldman,
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摘要:
A 22-month-old girl developed a rapidly fatal erythrophagocytic syndrome associated with evidence of acute EB viral infection. The association of hemophagocytic syndromes with viral, bacterial, and parasitic infections is discussed. All cases diagnosed as histiocytic medullary reticulosis should include attempts to detect possible association with infectious agents in addition to the assessment of host response.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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9. |
Acute bleomycin toxicity |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 249-252
Dorothy Ganick,
Mary Peters,
Gholam-Reza Hafez,
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摘要:
A case of acute pulmonary toxicity due to bleomycin leading to death in 60 hours is described in an 11-year-old male with Hodgkin's disease. This acute presentation in an immunologically comprised host caused consideration of etiologies other than drugs. Previous reports in the literature have not documented such an acute fatal course as a result of bleomycin toxicity.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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10. |
Persistent renal blastema (nephroblastomatosis) as a frequent precursor of Wilms' tumor; a pathological and clinical review Part 2. Significance of nephroblastomatosis in the genesis of Wilms' tumor |
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American Journal of Pediatric Hematology/Oncology,
Volume 2,
Issue 3,
1980,
Page 253-262
LOUIS DEHNER,
ROBERT PRICE,
Geoffrey Machin,
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摘要:
The historical development of the concept of nephroblastomatosis is reviewed. Subtypes of nephroblastomatosis are described, and their interrelationships are discussed.
ISSN:0192-8562
出版商:OVID
年代:1980
数据来源: OVID
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