ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTInvolvement of the central nervous system (CNS) is a well-recognized complication of acute lymphocytic leukemia. We studied the patterns of such relapse in 56 children with acute lymphocytic leukemia whose disease was classified as E-rosette-positive or E-rosette-negative on the basis of whether their leukemic blasts formed rosettes with sheep erythrocytes. In the E+ group, CNS relapse was more frequent, and relapse occurred at, or sooner after, diagnosis and was more frequently followed shortly thereafter by bone marrow relapse. In addition, the E+ group was more likely to present with focal neurologic syndromes with or without blasts in the cerebrospinal fluid, in contrast to the more common features of diffuse meningeal leukemia with increase in intracranial pressure. These observations suggest that the E-rosette-positive lymphoblasts are more likely to infiltrate into nerve and brain tissue rather than invade the meninges diffusely. If confirmed, these findings imply that treatment of the CNS involvement may need to be different in patients with E+ acute lymphocytic leukemia than in patients with E- acute lymphocytic leukemia.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTA nine-year-old black female who had been considered to have Hb SC disease was admitted with pain of the leg, neck, and upper chest. She had also been hospitalized approximately 20 times for treatment of recurrent pain. Further investigation by citrate agar gel electrophoresis and peptide mapping disclosed that the child had Hb SO Arab disease. She had mild hepatosplenomegaly and the hemoglobin concentration was 10.2 gm/dl. The clinical presentation of Hb SO Arab disease of our patient resembled that of Hb SD disease and was more severe than is Hb SC disease. The mother was found to have Hb O Arab trait. Two of the patient's siblings from a different father were found to have Hb CO Arab disease, an extremely rare condition. These children, 8 and 12 years old, are clinically asymptomatic. Clinical and laboratory data are presented.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTIn vitroinhibition of marrow granulopoiesis was produced by a well-characterized human neuroblastoma cell line (CHP 134). A standard double layer, semi-solid agar system was employed in the experiments. The inhibition was present whether the neuroblastoma cells were mixed with the marrow cells or whether they were separated in a contiguous agar layer. Irradiation of the neuroblastoma cells lessened the inhibitory effect but did not eradicate it. Medium conditioned by the neuroblastoma cells had a mild, but not statistically significant, suppressive effect upon granulopoiesis. Additional studies to define the precise mechanism of suppression are under-way.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTThe glycemic and insulin response to an oral glucose load was studied in 17 children with acute lymphoblastic leukemia (ALL) and 13 normal controls. The patients were randomly assigned to either group A, receiving prednisone and vincristine, or group B, receiving these agents and, in addition, L-asparaginase from days 9–19 of the study. The glucose load was performed prior to (phase I), and on days 8 (phase II), and 19 (phase HI) of chemotherapy. The mean glycemic response in both groups of patients was significantly higher than in controls at diagnosis and prior to any treatment, while mean insulin levels were not significantly different from controls. One week after initiation of treatment, the mean glycemic response improved, and was associated with hyperinsulinism. After the second week of treatment, the mean glucose and insulin response curves in group A were similar to controls. In group B, while insulin values returned to normal, blood glucose levels remained higher than in controls, but not significantly so. These findings suggest that: 1) The leukemic process itself, through mechanisms as yet undetermined, causes impairment of glucose tolerance, and 2) the diabetogenic effect of L-asparaginase is not manifested in all patients.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTPrognostic factors were evaluated in 25 children with autoimmune hemolytic anemia (AIHA). Patients with acute disease were generally 2–12 years of age at diagnosis, had a sudden onset of symptoms, showed low reticulocyte counts, had decreased numbers of nucleated red blood cells or early white blood cells precursors on peripheral blood smear, and had normal platelet counts. They responded well to steroids and the disease resolved within 6 months without mortality. Children with chronic AIHA were generally less than 2 or greater than 12 years of age, had a more prolonged onset of symptoms, had increased reticulocyte counts, had increased numbers of nucleated red blood cells and early white blood cell precursors on peripheral blood smear, and had decreased platelet counts. They had a variable response to steroids frequently requiring other modalities of treatments and had a mortality of 25%. Females in this group had a significant incidence of associated diseases. Autoantibodies were characterized as to temperature sensitivity and reaction with class specific antiglobulin reagents and were related to the type of AIHA.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTWe investigated 28 cystic fibrosis (CF) patients to determine why hypoxia from their obstructive pulmonary disease does not produce polycythemia. Oxygen saturation was lower and erythropoietin levels were higher in CF patients than in 25 age-comparable reference subjects (90.8% and 47 miμ vs. 94.7% and 29 miμ,p< 0.01). Hematocrit and red blood cell (RBC) indices were not different between groups. Serum vitamin and iron levels, ferrokinetics, RBC volume, and RBC survival were studied in 10 of the 28 CF patients. Total iron-binding capacity and vitamin E levels were low, and serum iron, ferritin, vitamin B12, and folate levels were normal in these patients. Red blood cell survival was minimally decreased in six patients although there was no other evidence for hemolysis. Ferrokinetics (59Fe) indicated a reduction in total erythropoiesis in only two patients. Plasma volume was high-normal in five and above normal in four CF patients; RBC mass was increased appropriately for each patient's degree of hypoxia, when compared to healthy individuals living at different altitudes. These results suggest that CF patients are able to compensate for hypoxia by increasing RBC mass; however, an expanded plasma volume prevents a detectable rise in hematocrit.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTSeventy-nine consecutive children with non-Hodgkin's lymphoma were treated with a uniform intensive radiotherapy-chemotherapy program including high-dose MTX and CNS prophylaxis. Burkitt-type NHL was diagnosed in 44% and convoluted cell-type NHL in 33%. Complete remission rate was 97.5%. Forty-eight of 79 children (61%) remain progression-free after 18–78 months of follow-up. Patients belonging to the Burkitt type subgroup showed a peculiar clinical behavior as well as a significantly shorter survival than the other NHL patients (3-year overall survival rates of 50% vs. 72%, respectively). Clinical stages were related to the progression-free survival.It is concluded that treatment should be tailored according to the histology (Burkitt-type NHL vs. other histologic types) and the clinical stage.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

ABSTRACTWe evaluated 100 children with normoblastemia and 400 control children in order to determine the significance of this finding in a pediatric population. None of the control children demonstrated nucleated erythrocytes (NRBC) in their peripheral blood. Among the 100 children with normoblastemia, 49% had underlying disorders associated with hypoxia. Only 8% of the children had malignancies. Eighty-eight percent of the patients in this study had obvious underlying disorders which accounted for their normoblastemia. However, those patients without an obvious etiology for their NRBC were at considerable risk for having bone marrow replacement.

ISSN:0192-8562    

出版商:OVID    

年代:1983

数据来源: OVID