摘要:

&NA;To assess the association of mucosal dysplasia and colonic cancer in patients with ulcerative colitis and to avoid bias in biopsy interpretation that may have affected results of previous studies, the authors examined coded histology slides from colectomy specimens of 22 patients who had ulcerative colitis and colonic cancer and 22 patients who had ulcerative colitis but no colonic cancer. As expected, it was found that dysplasia occurred contiguous to each cancer. However, at a distance from the cancer (i.e., in histology blocks not containing cancer), some dysplasia was found (low or high grade) in 16/22 cases (73 percent), and high grade dysplasia in 11/22 cases (50 percent). These results suggest that there may be a somewhat weaker association than previously reported between colonic cancer and dysplasia at a distance from the colonic cancer. Further, these results suggest that, in studies of dysplasia, it is important to avoid bias in biopsy interpretation and to describe sampling methods.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;Our clinical experience with 69 patients with metastatic colorectal cancer to the liver treated with hepatic artery chemotherapy is reviewed. All patients have had a minimum of six months follow‐up. The Infusaid®implantable drug delivery system was used by direct laparotomy in one third, and via the transaxillary approach in the remaining two thirds. Two thirds of the patients had at least 25 percent of the liver replaced with tumor. Chemotherapeutic agents included FUdR, mitomycin C, and BCNU. The overall response rate was 51 percent and 69 percent for the three‐drug combination. Efficacy was not different in patients who had received prior systemic fluorouracil. Median survival from start of hepatic artery chemotherapy was one year.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;In a retrospective review of 311 patients having subtotal colectomy for ulcerative colitis, information on the fate of the rectal stump was obtained in 288. Proctectomy was performed in 159 patients (55 percent); for persistent proctitis in 118 (41 percent), cancer prophylaxis in 37 (13 percent), and cancer in four (1.4 percent). One hundred twenty‐two patients (42 percent) had ileorectal anastomoses. Eighty‐four of these (69 percent) retained a functioning ileorectal anastomosis at the time of follow‐up or death, one to 22 years later, and an additional six patients (5 percent) had a satisfactory ileorectal anastomosis for five to 14 years before proctectomy. Cancer developed in the rectal stump in nine patients (3.1 percent), underscoring the need for either proctectomy (total or mucosal) or long‐term surveillance of the retained rectum. However, subtotal colectomy, by permitting ileorectal anastomosis or other sphincter‐preserving surgery at a later date, does have a definite place in many patients requiring surgery for ulcerative colitis.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;Twenty surgical specimens of appendiceal schistosomiasis were reviewed retrospectively. They constituted 1 percent of 1984 appendices seen among approximately 15,000 surgical specimensexamined at free central laboratories serving the Igbos of Nigeria, West Africa. Oviposition bySchistosoma haematobiumwas classified according to its association with suppurative appendicitis and normal appendices. Seven of ten infested appendices obtained at curative operations showed suppurative appendicitis, whereas eight of nine infested appendices removed at incidental appendectomies were negative. One interval appendectomy was also negative. It is postulated that utilization of this novel classification on a worldwide basis will help to end the controversy concerning the etiologic role of schistosome ova in acute appendicitis.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;The reported clinical manifestations of Turcot syndrome were studied to determine whether these corresponded to those of Turcot's original cases. Among the patients with well‐documented colonic lesions, the colonic lesions were classified into three groups. First, there was a main group in which colonic lesions had the following characteristics that coincided with those of Turcot's original cases: 1) a low number of polyps (20‐100), 2) large polyps over 3 cm in diameter, and 3) complication by colonic cancer during the second or third decades. In the second group, the patients had too few polyps to be diagnosed as polyposis. The third group included patients with numerous colonic polyps similar to those of familial polyposis coli. The recognition of these characteristics of colonic lesions may lead to early detection of glioma in the asymptomatic period.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;In a six‐year period (1977‐83), lesions were identified by enteroclysis in 26 patients with melena or recurrent gastrointestinal bleeding undiagnosed by other modalities. These included nine Meckel's diverticula, three metastatic lesions, three primary carcinomas, one lipoma, four leiomyomas, five surgically created blind pouches, one carcinoid, and one idiopathic dilatation of the ileum. Our experience suggests that, when the standard diagnostic procedures used to investigate chronic gastrointestinal blood loss are unrevealing, enteroclysis should be performed. The method is fast, accurate, is done in one sitting, and can be productive in the diagnostically difficult patient.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

&NA;Forty‐five patients with levator syndrome were treated by high voltage electrogalvanic stimulation of the levator ani by means of an intra‐anal probe. Voltage varied from 150 to 400 volts, depending on patient tolerance. Negative electrodes and 80 cycles per second were used for 20 minutes every other day. An average of five treatments was needed for complete pain relief. Excellent results (total pain relief) were obtained in 36 patients, good results in five, fair results in two, and poor results (no relief) in two. High voltage electrogalvanic stimulation is the treatment of choice for levator syndrome because it can be standardized, is well tolerated, and is over 90 percent effective.

ISSN:0012-3706    

出版商:OVID    

年代:1985

数据来源: OVID