摘要:

SummaryGenetic analysis of the kindred in this presentation indicates that the polyposis gene was transmitted as a simple mendelian dominant trait. The data showed no significant deviation from the hypothesis that the sexes are equally affected in polyposis; however, affected fathers produced a slight excess of affected sons, while affected mothers produced a marked excess of affected daughters which approached the P 0.05 level of significance. The incidence at birth of individuals with the polyposis gene was one in 6,850 for this Kentucky survey. Individuals possessing the polyposis gene had a relative biologic fitness of 84.85 per cent when compared with the general population. The penetrance of the polyposis gene in the kindred at the time of the investigation was 49.43 per cent. The mutation rate for the polyposis locus was 12 mutations per million loci per generation. Possible sources of error and bias entering into the above calculations have been discussed.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

SummaryMost fistulas are characterized by the uniform site of the internal or “primary” opening. A series of unusual anal fistulas has been described in which the internal opening was not situated at this usual place. In addition, other lesions resembling anal fistula are mentioned.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

SummaryA case of retrorectal neurilemoma and a review of world medical literature from 1935 to 1966, for specific nerve‐sheath tumors of the rectum and perirectal areas, have been presented. Sixteen cases have been studied. Often, nonspecific pain, a palpable mass and rectal dysfunction are the presenting symptoms. The diagnosis is made by microscopic examination. The neoplasm is encapsulated and has specific morphologic features which differentiate it from the neurofibroma and other tumors.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

SummaryA case has been presented in which the patient had acute fulminating amebiasis, complicated by hemorrhage, perforation of the colon, obstruction of the small bowel, pleuropulmonary disease and hepatic involvement. Treatment is discussed in the light of known therapeutic types of management which were altered to meet the demands of a combination of complications.Treatment was begun by administration of chloroquine, Diodoquin® and tetracycline orally. When vomiting intervened, emetine and tetracycline were administered parenterally. Hemorrhage responded to antiamebic treatment and anemia was corrected by blood replacement. Perforation was treated by administration of high doses of broad‐spectrum antibiotic agents, emetine and fluids. Obstruction of the small bowel, subsequent to perforation, was bypassed by a jejunoileostomy and transverse colostomy after repair of traumatically‐induced perforation of the friable bowel. Pneumonitis, amebic pleural effusion and hepatic involvement were treated by administration of emetine and chloroquine.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

ConclusionsThe results of this experiment indicate that 3:2′‐dimethyl‐4‐aminobiphenyl hydrochloride is unsuitable as a carcinogenic agent.Possibly, future experiments with the free amine form in the pure state should be attempted, perhaps utilizing radioactive tagging of the carcinogen to determine the carcinogenic metabolite. Periodic chemical and biologic assay should be made of a carcinogenic agent to determine the presence of contaminants.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID

摘要:

SummaryA case of Hirschsprung's disease in a 21‐year‐old man is reported. Hemoconcentration and hyperkalemia occurred after a soap‐and‐water enema. A possible mechanism of this phenomenon is discussed, and the significance of water intoxication is questioned.

ISSN:0012-3706    

出版商:OVID    

年代:1968

数据来源: OVID